Delivery Route Considerations for Designing Antigen‐Specific Biomaterial Strategies to Combat Autoimmunity

Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

(2022) Sam Afkhami et al.   CELL

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

(2022) Kjetil Bjornevik et al.   SCIENCE

Mapping the Mechanical and Immunological Profiles of Polymeric Microneedles to Enable Vaccine and Immunotherapy Applications

(2022) Shrey A. Shah et al.   Frontiers in Immunology

Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection

(2022) Jeffrey L. Americo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

(2021) Christina Krienke et al.   SCIENCE

Partridge and embryonated partridge egg as new preclinical models for candidiasis

(2021) Hadi Tavakkoli et al.   Scientific Reports

Synthetic Cationic Autoantigen Mimics Glatiramer Acetate Persistence at the Site of Injection and Is Efficacious Against Experimental Autoimmune Encephalomyelitis

(2021) Jimmy Y. Song et al.   Frontiers in Immunology

Exploiting Rational Assembly to Map Distinct Roles of Regulatory Cues during Autoimmune Therapy

(2021) Robert S. Oakes et al.   ACS Nano

PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance

(2021) Peter Y. Li et al.   JOURNAL OF CONTROLLED RELEASE

Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models

(2021) Xin Chen et al.   Science Translational Medicine

Antigen-Specific Treatment Modalities in MS: The Past, the Present, and the Future

(2021) Judith Derdelinckx et al.   Frontiers in Immunology

Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation

(2021) Brett E. Phillips et al.   Frontiers in Immunology

TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study

(2021) Ciarán P. Kelly et al.   GASTROENTEROLOGY

In Vivo Insulin Peptide Autoantigen Delivery by Mannosylated Sodium Alginate Nanoparticles Delayed but Could Not Prevent the Onset of Type 1 Diabetes in Nonobese Diabetic Mice

(2021) Yue Qu et al.   MOLECULAR PHARMACEUTICS

Biophysical Properties of Self-Assembled Immune Signals Impact Signal Processing and the Nature of Regulatory Immune Function

(2021) Eugene Froimchuk et al.   NANO LETTERS

Tolerogenic Nanoparticles Impacting B and T Lymphocyte Responses Delay Autoimmune Arthritis in K/BxN Mice

(2021) Amrita Srivastava et al.   ACS Chemical Biology

Multicomponent Plasmid Protects Mice From Spontaneous Autoimmune Diabetes

(2021) Philippe P. Pagni et al.   DIABETES

Intralymphatic Glutamic Acid Decarboxylase With Vitamin D Supplementation in Recent-Onset Type 1 Diabetes: A Double-Blind, Randomized, Placebo-Controlled Phase IIb Trial

(2021) Johnny Ludvigsson et al.   DIABETES CARE

Inhibition of glycolysis in the presence of antigen generates suppressive antigen-specific responses and restrains rheumatoid arthritis in mice

(2021) Joslyn L. Mangal et al.   BIOMATERIALS

Sex differences regulate immune responses in experimental autoimmune encephalomyelitis and multiple sclerosis

(2021) Lucy Ryan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tolerance induction by liposomes targeting a single CD8 epitope IGRP 206–214 in a model of type 1 diabetes is impeded by co‐targeting a CD4 + islet epitope

(2021) Irina Buckle et al.   IMMUNOLOGY AND CELL BIOLOGY

A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes

(2021) Sandrine Luce et al.   Frontiers in Immunology

Retinoic Acid-Containing Liposomes for the Induction of Antigen-Specific Regulatory T Cells as a Treatment for Autoimmune Diseases

(2021) Daniëlle ter Braake et al.   Pharmaceutics

Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes

(2020) Farah Arikat et al.   JOURNAL OF CONTROLLED RELEASE

Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease

(2020) Tobias L. Freitag et al.   GASTROENTEROLOGY

Ubiquitous antigen-specific T regulatory type 1 cells variably suppress hepatic and extrahepatic autoimmunity

(2020) Channakeshava Sokke Umeshappa et al.   JOURNAL OF CLINICAL INVESTIGATION

Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity

(2020) Sebastian Ols et al.   Cell Reports

Recent Advances in Antigen-Specific Immunotherapies for the Treatment of Multiple Sclerosis

(2020) Olga Kammona et al.   Brain Sciences

Dissolving microneedles for the delivery of peptides – Towards tolerance-inducing vaccines

(2020) Liliana R Pires et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Old dog new tricks: PLGA microparticles as adjuvant for insulin peptide fragment induced immune tolerance against type 1 diabetes

(2020) Mohan Liu et al.   MOLECULAR PHARMACEUTICS

Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide—for type 1 diabetes

(2020) Tatjana Nikolic et al.   Lancet Diabetes & Endocrinology

Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides

(2020) R.K Singh et al.   Nanomedicine-Nanotechnology Biology and Medicine

Combination Treatment with Antigen-Specific Dual-Sized Microparticle System Plus Anti-CD3 Immunotherapy Fails to Synergize to Improve Late-Stage Type 1 Diabetes Prevention in Nonobese Diabetic Mice

(2020) J. M. Stewart et al.   ACS Biomaterials-Science & Engineering

Modulating lung immune cells by pulmonary delivery of antigen-specific nanoparticles to treat autoimmune disease

(2020) Eiji Saito et al.   Science Advances

Tolerogenic nanoparticles suppress central nervous system inflammation

(2020) Jessica E. Kenison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(d,l-lactide-co-glycolide) (PLGA) Nanoparticles Loaded with Proteolipid Protein (PLP)—Exploring a New Administration Route

(2020) Alexandre Ferreira Lima et al.   Polymers

Tocopherol Emulsions as Functional Autoantigen Delivery Vehicles Evoke Therapeutic Efficacy in Experimental Autoimmune Encephalomyelitis

(2019) J. Daniel Griffin et al.   MOLECULAR PHARMACEUTICS

Dual-sized microparticle system generates suppressive dendritic cells, and prevents and reverses type 1 diabetes in the non-obese diabetic mouse

(2019) Jamal S Lewis et al.   ACS Biomaterials-Science & Engineering

Critical size limit of biodegradable nanoparticles for enhanced lymph node trafficking and paracortex penetration

(2019) Gregory P. Howard et al.   Nano Research

Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy

(2019) M. Dul et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanoparticles Containing an Insulin–ChgA Hybrid Peptide Protect from Transfer of Autoimmune Diabetes by Shifting the Balance between Effector T Cells and Regulatory T Cells

(2019) Braxton L. Jamison et al.   JOURNAL OF IMMUNOLOGY

Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial

(2019) Irati Zubizarreta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role of air pollution in autoimmune diseases

(2019) Chan-Na Zhao et al.   AUTOIMMUNITY REVIEWS

Induction of antigen-specific immune tolerance using biodegradable nanoparticles containing antigen and dexamethasone

(2019) Sang-Hyun Kim et al.   International Journal of Nanomedicine

Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: the GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol

(2019) Anette-Gabriele Ziegler et al.   BMJ Open

Biomaterials as Tools to Decode Immunity

(2019) Haleigh B. Eppler et al.   ADVANCED MATERIALS

Design of biodegradable nanoparticles to modulate phenotypes of antigen-presenting cells for antigen-specific treatment of autoimmune disease

(2019) Eiji Saito et al.   BIOMATERIALS

Antigen-specific immune decoys intercept and exhaust autoimmunity to prevent disease

(2019) J. Daniel Griffin et al.   BIOMATERIALS

A Humanized Mouse Model to Study Type 1 Diabetes

(2018) Sandrine Luce et al.   DIABETES

Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice

(2018) Yulin Chen et al.   DIABETOLOGIA

Direct modulation of myelin-autoreactive CD4+ and CD8+ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules

(2018) Weiya Pei et al.   International Journal of Nanomedicine

Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells

(2018) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis

(2018) Ivana Bjelobaba et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity

(2018) John B. Harley et al.   NATURE GENETICS

Effects of ATX-MS-1467 immunotherapy over 16 weeks in relapsing multiple sclerosis

(2018) Jeremy Chataway et al.   NEUROLOGY

Antigen-Specific Tolerization and Targeted Delivery as Therapeutic Strategies for Autoimmune Diseases

(2018) Akhilesh Kumar Shakya et al.   TRENDS IN BIOTECHNOLOGY

Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis

(2018) Robert A. LaMothe et al.   Frontiers in Immunology

Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31

(2018) Naihan Chen et al.   Advanced Healthcare Materials

Celiac Disease and Nonceliac Gluten Sensitivity

(2017) Maureen M. Leonard et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Co-delivery of autoantigen and dexamethasone in incomplete Freund's adjuvant ameliorates experimental autoimmune encephalomyelitis

(2017) Laura Northrup et al.   JOURNAL OF CONTROLLED RELEASE

Pulmonary Administration of Soluble Antigen Arrays Is Superior to Antigen in Treatment of Experimental Autoimmune Encephalomyelitis

(2017) Christopher Kuehl et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance

(2017) Robert Kuo et al.   MOLECULAR THERAPY

Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles Using Peptide-Polymer Bioconjugates

(2017) Ryan M. Pearson et al.   MOLECULAR THERAPY

An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy

(2017) Derrick P. McCarthy et al.   Nanomedicine-Nanotechnology Biology and Medicine

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

(2017) Santiswarup Singha et al.   Nature Nanotechnology

Intralymphatic Injection of Autoantigen in Type 1 Diabetes

(2017) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type 1 diabetes induction in humanized mice

(2017) Shulian Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation

(2017) Catia S. Verbeke et al.   Advanced Healthcare Materials

The Multiple Sclerosis (MS) Genetic Risk Factors Indicate both Acquired and Innate Immune Cell Subsets Contribute to MS Pathogenesis and Identify Novel Therapeutic Opportunities

(2017) Grant P. Parnell et al.   Frontiers in Immunology

Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells

(2017) Gustaf Lindgren et al.   Frontiers in Immunology

Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model

(2017) Medhat A. Al-Ghobashy et al.   Scientific Reports

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

(2016) Lisa H. Tostanoski et al.   Cell Reports

Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes

(2015) Ezio Bonifacio et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetics of autoimmune diseases: insights from population genetics

(2015) Paula S Ramos et al.   JOURNAL OF HUMAN GENETICS

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

(2015) Helen Benham et al.   Science Translational Medicine

Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future

(2015) Yotam Levin et al.   Human Vaccines & Immunotherapeutics

Intralymphatic immunotherapy

(2015) Gabriela Senti et al.   World Allergy Organization Journal

Obesity in autoimmune diseases: Not a passive bystander

(2014) Mathilde Versini et al.   AUTOIMMUNITY REVIEWS

Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus

(2014) M. J. Walker et al.   CLINICAL MICROBIOLOGY REVIEWS

From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development

(2014) Avraham Ben-Nun et al.   JOURNAL OF AUTOIMMUNITY

Epstein-Barr Virus in Systemic Autoimmune Diseases

(2013) Anette Holck Draborg et al.   Clinical & Developmental Immunology

Current immunotherapy in rheumatoid arthritis

(2013) Florian MP Meier et al.   Immunotherapy

Transdermal Application of Myelin Peptides in Multiple Sclerosis Treatment

(2013) Agata Walczak et al.   JAMA Neurology

In Vivo Clearance and Toxicity of Monodisperse Iron Oxide Nanocrystals

(2012) Luo Gu et al.   ACS Nano

A phase III study evaluating the efficacy and safety of MBP8298 in secondary progressive MS

(2011) M. S. Freedman et al.   NEUROLOGY

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

(2011) C. M. Jewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune regulation of multiple sclerosis by transdermally applied myelin peptides

(2010) Maciej Juryńczyk et al.   ANNALS OF NEUROLOGY

Antigen-specific immunotherapy of autoimmune and allergic diseases

(2010) Catherine A Sabatos-Peyton et al.   CURRENT OPINION IN IMMUNOLOGY

Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential

(2010) M. Peakman et al.   DIABETES

Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial

(2009) Eva C. Koffeman et al.   ARTHRITIS AND RHEUMATISM

Effects of tobacco smoke on immunity, inflammation and autoimmunity

(2009) Yoav Arnson et al.   JOURNAL OF AUTOIMMUNITY

Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy

(2009) Tihamer Orban et al.   JOURNAL OF AUTOIMMUNITY

A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis

(2009) Wei Wei et al.   ARTHRITIS RESEARCH & THERAPY

Sex Differences in Autoimmune Disease from a Pathological Perspective

(2008) DeLisa Fairweather et al.   AMERICAN JOURNAL OF PATHOLOGY

Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis

(2008) Hideki Garren et al.   ANNALS OF NEUROLOGY

Recent Advances in the Genetics of Autoimmune Disease

(2008) Peter K. Gregersen et al.   Annual Review of Immunology

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

(2008) Kirsti Näntö-Salonen et al.   LANCET