Immunometabolism: From basic mechanisms to translation

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

(2020) Florian J. Weisel et al.   NATURE IMMUNOLOGY

Fueling influenza and the immune response: Implications for metabolic reprogramming during influenza infection and immunometabolism

(2020) Azadeh Bahadoran et al.   IMMUNOLOGICAL REVIEWS

The immunological Warburg effect: Can a metabolic‐tumor‐stroma score (MeTS) guide cancer immunotherapy?

(2020) Peter J. Siska et al.   IMMUNOLOGICAL REVIEWS

Obesity and CD8 T cell metabolism: Implications for anti‐tumor immunity and cancer immunotherapy outcomes

(2020) William J. Turbitt et al.   IMMUNOLOGICAL REVIEWS

Metabolic adaptation orchestrates tissue context‐dependent behavior in regulatory T cells

(2020) Haiping Wang et al.   IMMUNOLOGICAL REVIEWS

Visceral adipose tissue Tregs and the cells that nurture them

(2020) Chaoran Li et al.   IMMUNOLOGICAL REVIEWS

Complement and human T cell metabolism: Location, location, location

(2020) Erin E. West et al.   IMMUNOLOGICAL REVIEWS

The role of metabolic checkpoint regulators in B cell survival and transformation

(2020) Julia Jellusova   IMMUNOLOGICAL REVIEWS

Metabolic determinants of lupus pathogenesis

(2020) Xiangyu Teng et al.   IMMUNOLOGICAL REVIEWS

mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions

(2020) Hongling Huang et al.   IMMUNOLOGICAL REVIEWS

Chemical individuality in T cells: A Garrodian view of immunometabolism

(2020) Peter J. McGuire   IMMUNOLOGICAL REVIEWS

Adipose tissue macrophages: Unique polarization and bioenergetics in obesity

(2020) Heather L. Caslin et al.   IMMUNOLOGICAL REVIEWS

Cell‐intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg

(2020) Nikki Teijlingen Bakker et al.   IMMUNOLOGICAL REVIEWS

Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

(2019) Alex J. Freemerman et al.   JOURNAL OF IMMUNOLOGY

A lipase-independent pathway of lipid release and immune modulation by adipocytes

(2019) Stephen E. Flaherty et al.   SCIENCE

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

(2019) Daniel J. Puleston et al.   Cell Metabolism

Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity

(2019) Sung Hoon Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters

(2019) Wei Li et al.   Frontiers in Immunology

PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8+ T lymphocytes

(2019) Jesús Ogando et al.   Journal for ImmunoTherapy of Cancer

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

(2019) Jiyeon Kim et al.   Cell Metabolism

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2

(2019) Anne-Valérie Burgener et al.   NATURE IMMUNOLOGY

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Distinct microbial communities that differ by race, stage, or breast-tumor subtype in breast tissues of non-Hispanic Black and non-Hispanic White women

(2019) Alana Smith et al.   Scientific Reports

Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb

(2019) Hao Shi et al.   IMMUNITY

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

(2018) Gang Xiao et al.   CELL

TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype

(2018) Chaoran Li et al.   CELL

Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8 + T Cells

(2018) Glenn R. Bantug et al.   IMMUNITY

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+Regulatory T Cells

(2018) Im-Hong Sun et al.   JOURNAL OF IMMUNOLOGY

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

(2018) Munir Akkaya et al.   NATURE IMMUNOLOGY

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

(2018) Kuang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

(2018) Georges Abboud et al.   Frontiers in Immunology

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Characterization of regulatory T cells in obese omental adipose tissue in humans

(2018) Dan Wu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

(2018) Xavier Michelet et al.   NATURE IMMUNOLOGY

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

Cardiovascular disease in systemic lupus erythematosus: A comprehensive update

(2017) Mayra Giannelou et al.   JOURNAL OF AUTOIMMUNITY

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease

(2017) Awo Akosua Kesewa Layman et al.   Nature Communications

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent

(2016) Lingling Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

(2015) Martin Kolev et al.   IMMUNITY

Investigation of the Association Between the Fecal Microbiota and Breast Cancer in Postmenopausal Women: a Population-Based Case-Control Pilot Study

(2015) James J. Goedert et al.   JNCI-Journal of the National Cancer Institute

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Investigation of the Association Between the Fecal Microbiota and Breast Cancer in Postmenopausal Women: a Population-Based Case-Control Pilot Study

(2015) James J. Goedert et al.   JNCI-Journal of the National Cancer Institute

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity

(2013) D. C. Saucillo et al.   JOURNAL OF IMMUNOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Liver Kinase B1 Is a Central Regulator of T Cell Development, Activation, and Metabolism

(2011) Nancie J. MacIver et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE