Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity

Host cell glutamine metabolism as a potential antiviral target

(2021) Sandro Massao Hirabara et al.   CLINICAL SCIENCE

More than just protein building blocks: How amino acids and related metabolic pathways fuel macrophage polarization

(2021) Markus Kieler et al.   FEBS Journal

Vitamin D, zinc and glutamine: Synergistic action with OncoTherad immunomodulator in interferon signaling and COVID‑19 (Review)

(2021) José Name et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID‐19

(2021) Aradhana Mariam Philips et al.   Obesity Reviews

Tryptophan and indole metabolism in immune regulation

(2021) Alessandra Fiore et al.   CURRENT OPINION IN IMMUNOLOGY

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

A virus that has gone viral: amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding, and thus, infectivity

(2020) Priyanka Saha et al.   BIOSCIENCE REPORTS

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Diverse Functions of Polyamines in Virus Infection

(2020) Mason R. Firpo et al.   Biomolecules

Obesity and COVID‐19: The mTOR pathway as a possible culprit

(2020) Alireza Bolourian et al.   Obesity Reviews

Dengue Virus Induced COX-2 Signaling Is Regulated Through Nutrient Sensor GCN2

(2020) Sumbul Afroz et al.   Frontiers in Immunology

Comparative genome analysis of novel coronavirus (SARS-CoV-2) from different geographical locations and the effect of mutations on major target proteins: An in silico insight

(2020) Mohd Imran Khan et al.   PLoS One

Arginine depletion as a therapeutic approach for patients with COVID-19

(2020) Joseph M. Grimes et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Metabolic control of BRISC–SHMT2 assembly regulates immune signalling

(2019) Miriam Walden et al.   NATURE

Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation

(2019) Liang Wei Wang et al.   Cell Metabolism

One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

(2019) Weiwei Yu et al.   MOLECULAR CELL

Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy

(2018) Srikanth Battu et al.   PLOS BIOLOGY

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

(2018) Vinicius Cruzat et al.   Nutrients

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

(2017) Giada Mondanelli et al.   IMMUNITY

Glutamine supplementation suppresses herpes simplex virus reactivation

(2017) Kening Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Dual role of arginine metabolism in establishing pathogenesis

(2016) Mayuri Gogoi et al.   CURRENT OPINION IN MICROBIOLOGY

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

(2016) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals

(2015) Ursula Grohmann et al.   Frontiers in Immunology

Crosstalk between the Tor and Gcn2 pathways in response to different stresses

(2014) Gro Elise Rødland et al.   CELL CYCLE

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

(2014) Alban Bessede et al.   NATURE

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation

(2013) Jinsam Chang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophages, fat, and the emergence of immunometabolism

(2013) Anthony W. Ferrante   JOURNAL OF CLINICAL INVESTIGATION

Inducible Nitric Oxide Contributes to Viral Pathogenesis Following Highly Pathogenic Influenza Virus Infection in Mice

(2013) Lucy A. Perrone et al.   JOURNAL OF INFECTIOUS DISEASES

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Antibacterial Properties of the Mammalian L-Amino Acid Oxidase IL4I1

(2013) Marie-Line Puiffe et al.   PLoS One

Indoleamine 2,3-dioxygenase: From catalyst to signaling function

(2012) Francesca Fallarino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity

(2012) Tracy L. McGaha et al.   IMMUNOLOGICAL REVIEWS

Resurgence of Serine: An Often Neglected but Indispensable Amino Acid

(2012) Satish C. Kalhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Glutamine and Leucine Provide Enhanced Protective Immunity Against Mucosal Infection with Herpes Simplex Virus Type 1

(2012) Erdenebileg Uyangaa et al.   Immune Network

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation

(2011) R. Rotondo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Control of immune response by amino acid metabolism

(2010) Ursula Grohmann et al.   IMMUNOLOGICAL REVIEWS

Metabolic and Genomic Response to Dietary Isocaloric Protein Restriction in the Rat

(2010) Satish C. Kalhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

Arginase: an emerging key player in the mammalian immune system

(2009) Markus Munder   BRITISH JOURNAL OF PHARMACOLOGY

Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels

(2008) M. H. Stipanuk et al.   AMINO ACIDS

Glutamine Deprivation Causes Enhanced Plating Efficiency of a Herpes Simplex Virus Type 1 ICP0-Null Mutant

(2008) R. M. Bringhurst et al.   JOURNAL OF VIROLOGY