Metabolic communication in the tumour–immune microenvironment

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

(2022) Shogo Kumagai et al.   CANCER CELL

Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer

(2022) Luigi Ippolito et al.   CANCER RESEARCH

PERK is a critical metabolic hub for immunosuppressive function in macrophages

(2022) Lydia N. Raines et al.   NATURE IMMUNOLOGY

Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis

(2022) Jun-Long Zhao et al.   Cell Reports

Asparagine enhances LCK signalling to potentiate CD8+ T-cell activation and anti-tumour responses

(2021) Jun Wu et al.   NATURE CELL BIOLOGY

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

(2021) Xingzhe Ma et al.   Cell Metabolism

Caloric restriction impairs regulatory T-cells within the tumor microenvironment after radiation and primes effector T-cells

(2021) Gregor Manukian et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Lipid signalling enforces functional specialization of Treg cells in tumours

(2021) Seon Ah Lim et al.   NATURE

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

A plateful of medicine

(2021) Jocelyn Kaiser   SCIENCE

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming

(2021) Samantha M. Morrissey et al.   Cell Metabolism

Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming

(2021) Simon Hirschberger et al.   EMBO Molecular Medicine

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

Notch1/TAZ axis promotes aerobic glycolysis and immune escape in lung cancer

(2021) Mian Xie et al.   Cell Death & Disease

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

(2021) Chengxian Xu et al.   Cell Reports

Amino Acid Transport and Metabolism in Myeloid Function

(2021) Marie Jo Halaby et al.   Frontiers in Immunology

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

(2021) Lingyun Long et al.   NATURE

Metabolic modulation of tumours with engineered bacteria for immunotherapy

(2021) Fernando P. Canale et al.   NATURE

Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity

(2021) Giusy Di Conza et al.   NATURE IMMUNOLOGY

Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of dietary composition

(2021) Laura C. D. Pomatto-Watson et al.   Nature Communications

Macrophages are metabolically heterogeneous within the tumor microenvironment

(2021) Xenia Geeraerts et al.   Cell Reports

Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited

(2021) Chenfeng Han et al.   Cancer Immunology Research

Lactate supports a metabolic-epigenetic link in macrophage polarization

(2021) Jordan T. Noe et al.   Science Advances

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

(2020) Jin-Tao Li et al.   NATURE CELL BIOLOGY

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

(2020) Haiping Wang et al.   NATURE IMMUNOLOGY

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

(2020) Julia M Marchingo et al.   eLife

Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

(2020) Mei-lin Weng et al.   Nature Communications

Myeloid Cell-Derived Arginase in Cancer Immune Response

(2020) Tomasz M. Grzywa et al.   Frontiers in Immunology

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

(2020) Min-Hee Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

(2020) Yingjie Bian et al.   NATURE

Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

(2020) Yi-Ru Yu et al.   NATURE IMMUNOLOGY

Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

(2020) Helene Rundqvist et al.   eLife

IDO Expression in Cancer: Different Compartment, Different Functionality?

(2020) Annabel Meireson et al.   Frontiers in Immunology

Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways

(2020) Yi-Na Liu et al.   Frontiers in Immunology

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

(2020) Kun Yang et al.   Frontiers in Immunology

Metabolic reprograming of tumor-associated macrophages

(2020) Abhishek Puthenveetil et al.   Annals of Translational Medicine

NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

(2020) Hongwei Lv et al.   Cell Metabolism

Lactate Limits T Cell Proliferation via the NAD(H) Redox State

(2020) William J. Quinn et al.   Cell Reports

Immunometabolism in the Tumor Microenvironment

(2020) Dominic G. Roy et al.   Annual Review of Cancer Biology-Series

Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer

(2020) Deanna N. Edwards et al.   JOURNAL OF CLINICAL INVESTIGATION

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer

(2019) Shawn P. Kubli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

(2019) Mark R Sullivan et al.   eLife

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

(2019) Xia Gao et al.   NATURE

Immune evasion before tumour invasion in early lung squamous carcinogenesis

(2019) Céline Mascaux et al.   NATURE

Targeting Glucose Metabolism to Enhance Immunotherapy: Emerging Evidence on Intermittent Fasting and Calorie Restriction Mimetics

(2019) William J. Turbitt et al.   Frontiers in Immunology

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth

(2019) Arvin M. Gouw et al.   Cell Metabolism

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

(2019) Niranjan Venkateswaran et al.   GENES & DEVELOPMENT

Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance

(2019) Mytrang H. Do et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Aerobic glycolysis is a metabolic requirement to maintain the M2-like polarization of tumor-associated macrophages

(2019) Natália M. de-Brito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reprogramming of fatty acid metabolism in cancer

(2019) Nikos Koundouros et al.   BRITISH JOURNAL OF CANCER

Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb

(2019) Hao Shi et al.   IMMUNITY

The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention

(2019) Ki Wung Chung et al.   Nutrients

Ketogenic diet in cancer therapy

(2018) Daniela D. Weber et al.   Aging-US

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

(2018) Feilong Wang et al.   Cell Metabolism

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

(2018) Mylène Tajan et al.   Cell Metabolism

The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells

(2018) M. Carmen Lafita-Navarro et al.   GENES & DEVELOPMENT

We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of6-Diazo-5-oxo-L-norleucine

(2018) Kathryn M. Lemberg et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

(2018) Benjamin D. Hopkins et al.   NATURE

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

(2018) Matthew M. Gubin et al.   CELL

Autophagy and intermittent fasting: the connection for cancer therapy?

(2018) F Antunes et al.   Clinics

Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation

(2017) Rainer J. Klement   MEDICAL ONCOLOGY

Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity

(2017) Kenji Chamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COX2/mPGES1/PGE2pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells

(2017) Victor Prima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts through prevention of ROS-mediated apoptosis

(2017) Shiou-Ling Jian et al.   Cell Death & Disease

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

(2017) Erika M. Palmieri et al.   Cell Reports

2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation

(2017) Qingjie Zhao et al.   Frontiers in Immunology

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

(2016) Stefano Di Biase et al.   CANCER CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

(2016) Mathias Wenes et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation

(2016) Min Pan et al.   NATURE CELL BIOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

(2016) Tetsuya Kimura et al.   Nature Communications

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

(2016) Suzanne I.S. Mosely et al.   Cancer Immunology Research

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Cutting Edge: Hypoxia-Inducible Factor 1 Negatively Regulates Th1 Function

(2015) Hussein Shehade et al.   JOURNAL OF IMMUNOLOGY

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Preventing Allograft Rejection by Targeting Immune Metabolism

(2015) Chen-Fang Lee et al.   Cell Reports

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

(2015) Rikke B. Holmgaard et al.   Cell Reports

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

(2015) Chakrapani Tripathi et al.   Oncotarget

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

L-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

(2014) M. Fletcher et al.   CANCER RESEARCH

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Fasting Therapy for Treating and Preventing Disease - Current State of Evidence

(2014) Andreas Michalsen et al.   FORSCHENDE KOMPLEMENTARMEDIZIN

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Caloric Restriction

(2013) Connie W. Bales et al.   Journal of Cardiopulmonary Rehabilitation and Prevention

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer

(2013) J. Yu et al.   JOURNAL OF IMMUNOLOGY

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated CD69+ T Cells Foster Immune Privilege by Regulating IDO Expression in Tumor-Associated Macrophages

(2011) Q. Zhao et al.   JOURNAL OF IMMUNOLOGY

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression: the role of adenosine receptor A2

(2009) Jintang Sun et al.   Cellular & Molecular Immunology

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY