Nanotechnology for Enhanced Cytoplasmic and Organelle Delivery of Bioactive Molecules to Immune Cells

Nanomaterials for T-cell cancer immunotherapy

(2021) Ningqiang Gong et al.   Nature Nanotechnology

In Vivo T Cell-Targeting Nanoparticle Drug Delivery Systems: Considerations for Rational Design

(2021) Paula M. Cevaal et al.   ACS Nano

Key principles and methods for studying the endocytosis of biological and nanoparticle therapeutics

(2021) Joshua J. Rennick et al.   Nature Nanotechnology

Target Reprogramming Lysosomes of CD8+ T Cells by a Mineralized Metal–Organic Framework for Cancer Immunotherapy

(2021) Qin Zhao et al.   ADVANCED MATERIALS

Delivery of nanoparticle antigens to antigen-presenting cells: from extracellular specific targeting to intracellular responsive presentation

(2021) Fei Wang et al.   JOURNAL OF CONTROLLED RELEASE

Immune complex-induced apoptosis and concurrent immune complex clearance are anti-inflammatory neutrophil functions

(2021) Utsa Karmakar et al.   Cell Death & Disease

The evolution of commercial drug delivery technologies

(2021) Ava M. Vargason et al.   Nature Biomedical Engineering

Mechanisms and functions of endocytosis in T cells

(2021) John C. Charpentier et al.   Cell Communication and Signaling

Sialic acid-conjugate modified doxorubicin nanoplatform for treating neutrophil-related inflammation

(2021) Shuo Wang et al.   JOURNAL OF CONTROLLED RELEASE

The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines

(2021) Takashi Nakamura et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Immune-mediated inflammation across disease boundaries: breaking down research silos

(2021) Christopher D. Buckley et al.   NATURE IMMUNOLOGY

Photothermal nanofibres enable safe engineering of therapeutic cells

(2021) Ranhua Xiong et al.   Nature Nanotechnology

Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

(2020) John C. Charpentier et al.   Nature Communications

Sequential and timely combination of cancer nanovaccine with immune checkpoint blockade effectively inhibits tumor growth and relapse

(2020) Sangyong Jon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

(2020) Shi Su et al.   Nanomaterials

Cellular backpacks for macrophage immunotherapy

(2020) C. Wyatt Shields et al.   Science Advances

Nanomedicine for improvement of dendritic cell-based cancer immunotherapy

(2020) Vida Hashemi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

(2020) Dan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proton-driven transformable nanovaccine for cancer immunotherapy

(2020) Ningqiang Gong et al.   Nature Nanotechnology

Exploring the NK cell platform for cancer immunotherapy

(2020) Jacob A. Myers et al.   Nature Reviews Clinical Oncology

Endothelial cells, neutrophils and platelets: getting to the bottom of an inflammatory triangle

(2020) Tima Dehghani et al.   Open Biology

Cytopharmaceuticals: An emerging paradigm for drug delivery

(2020) Weishuo Li et al.   JOURNAL OF CONTROLLED RELEASE

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Combination of metabolic intervention and T cell therapy enhances solid tumor immunotherapy

(2020) Meixi Hao et al.   Science Translational Medicine

Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo

(2019) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

(2019) Nathan D. Donahue et al.   ADVANCED DRUG DELIVERY REVIEWS

Mannosylated graphene oxide as macrophage-targeted delivery system for enhanced intracellular M.tuberculosis killing efficiency

(2019) Jiang Pi et al.   Materials Science & Engineering C-Materials for Biological Applications

The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis

(2019) Francesco Moroni et al.   MEDIATORS OF INFLAMMATION

Injectable, long-acting PLGA formulations: Analyzing PLGA and understanding microparticle formation

(2019) Kinam Park et al.   JOURNAL OF CONTROLLED RELEASE

Engineering dendritic cell vaccines to improve cancer immunotherapy

(2019) Caleb R. Perez et al.   Nature Communications

Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke

(2019) Can Yang Zhang et al.   Science Advances

Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes

(2018) Vahid Mirshafiee et al.   ACS Nano

Cationic polymers for non-viral gene delivery to human T cells

(2018) Brynn R. Olden et al.   JOURNAL OF CONTROLLED RELEASE

Reducing the Cytotoxicity of Lipid Nanoparticles Associated with a Fusogenic Cationic Lipid in a Natural Killer Cell Line by Introducing a Polycation-Based siRNA Core

(2018) Takashi Nakamura et al.   MOLECULAR PHARMACEUTICS

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

(2018) Li Tang et al.   NATURE BIOTECHNOLOGY

A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation

(2018) Ewoud B. Compeer et al.   Nature Communications

Photothermally Controlled MHC Class I Restricted CD8+ T-Cell Responses Elicited by Hyaluronic Acid Decorated Gold Nanoparticles as a Vaccine for Cancer Immunotherapy

(2018) Fengqiang Cao et al.   Advanced Healthcare Materials

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts

(2018) Martin P. Stewart et al.   CHEMICAL REVIEWS

Tolerising cellular therapies: what is their promise for autoimmune disease?

(2018) Chijioke H Mosanya et al.   ANNALS OF THE RHEUMATIC DISEASES

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Neoadjuvant Chemotherapy Based on Abraxane/Human Neutrophils Cytopharmaceuticals with Radiotherapy for Gastric Cancer

(2018) Caoyun Ju et al.   Small

Fluorinated Redox-Responsive Poly(amidoamine) as a Vaccine Delivery System for Antitumor Immunotherapy

(2018) Hongyuan Yuan et al.   ACS Biomaterials-Science & Engineering

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

(2017) Tyrel T. Smith et al.   Nature Nanotechnology

Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

(2017) Jingwei Xue et al.   Nature Nanotechnology

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

(2017) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

(2017) H. F. Moffett et al.   Nature Communications

Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy

(2016) Jayoung Kim et al.   Acta Biomaterialia

Physical and mechanical properties of PLA, and their functions in widespread applications — A comprehensive review

(2016) Shady Farah et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain

(2016) Xiaowei Li et al.   BIOMATERIALS

Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation

(2016) Ce Wang et al.   BIOMATERIALS

Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma

(2016) Yuran Xie et al.   JOURNAL OF CONTROLLED RELEASE

Drug delivery to macrophages: Challenges and opportunities

(2016) Yihua Pei et al.   JOURNAL OF CONTROLLED RELEASE

pH-Responsive Poly(d,l-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response

(2015) Qi Liu et al.   ACS Nano

NK-92: an ‘off-the-shelf therapeutic’ for adoptive natural killer cell-based cancer immunotherapy

(2015) Garnet Suck et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The regulatory role of serum response factor pathway in neutrophil inflammatory response

(2015) Ashley Taylor et al.   CURRENT OPINION IN HEMATOLOGY

Avoidance of Autophagy Mediated by PlcA or ActA Is Required for Listeria monocytogenes Growth in Macrophages

(2015) Gabriel Mitchell et al.   INFECTION AND IMMUNITY

Delivery of rifampicin-chitin nanoparticles into the intracellular compartment of polymorphonuclear leukocytes

(2015) K.T. Smitha et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Enabling cytoplasmic delivery and organelle targeting by surface modification of nanocarriers

(2015) Alessandro Parodi et al.   Nanomedicine

Biocompatible mannosylated endosomal-escape nanoparticles enhance selective delivery of short nucleotide sequences to tumor associated macrophages

(2015) Ryan A. Ortega et al.   Nanoscale

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells

(2015) Linda Quatrini et al.   Science Signaling

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells

(2015) Linda Quatrini et al.   Science Signaling

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity

(2015) Adam P. Levine et al.   PLoS One

Neutral polymer micelle carriers with pH-responsive, endosome-releasing activity modulate antigen trafficking to enhance CD8+ T cell responses

(2014) Salka Keller et al.   JOURNAL OF CONTROLLED RELEASE

Enhancing endosomal escape for nanoparticle mediated siRNA delivery

(2014) Da Ma   Nanoscale

Zwitterionic-Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System

(2014) Karina Pombo García et al.   Small

Targeted nanoparticles in mitochondrial medicine

(2014) Rakesh K. Pathak et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Recent advancements in the cardiovascular drug carriers

(2014) Baljeet Singh et al.   Artificial Cells Nanomedicine and Biotechnology

pH-Responsive Nanoparticle Vaccines for Dual-Delivery of Antigens and Immunostimulatory Oligonucleotides

(2013) John T. Wilson et al.   ACS Nano

Treatment of patients with advanced cancer with the natural killer cell line NK-92

(2013) Torsten Tonn et al.   CYTOTHERAPY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Biodegradable synthetic high-density lipoprotein nanoparticles for atherosclerosis

(2013) Sean Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mimicking cellular transport mechanism in stem cells through endosomal escape of new peptide-coated quantum dots

(2013) Karthikeyan Narayanan et al.   Scientific Reports

Inhibition of Human Neutrophil Elastase by α1-Antitrypsin Functionalized Colloidal Microcarriers

(2012) Uta Reibetanz et al.   ACS Nano

Self-Assembled Squalenoylated Penicillin Bioconjugates: An Original Approach for the Treatment of Intracellular Infections

(2012) Nicolas Sémiramoth et al.   ACS Nano

Precision Intracellular Delivery Based on Optofluidic Polymersome Rupture

(2012) Andreas E. Vasdekis et al.   ACS Nano

Encapsulated group BStreptococcusmodulates dendritic cell functions via lipid rafts and clathrin-mediated endocytosis

(2012) Paul Lemire et al.   CELLULAR MICROBIOLOGY

Nanogel vaccines targeting dendritic cells: Contributions of the surface decoration and vaccine cargo on cell targeting and activation

(2012) L.J. Thomann-Harwood et al.   JOURNAL OF CONTROLLED RELEASE

Lipase-Sensitive Polymeric Triple-Layered Nanogel for “On-Demand” Drug Delivery

(2012) Meng-Hua Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural Innate and Adaptive Immunity to Cancer

(2011) Matthew D. Vesely et al.   Annual Review of Immunology

T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

(2011) Nuria Martínez-Martín et al.   IMMUNITY

Caveolae-dependent Endocytosis Is Required for Class A Macrophage Scavenger Receptor-mediated Apoptosis in Macrophages

(2011) Xu-Dong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Inflammasome-dependent Pyroptosis by Carbon Black Nanoparticles

(2011) Anna C. Reisetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Modeling receptor-mediated endocytosis of polymer-functionalized iron oxide nanoparticles by human macrophages

(2010) Oleg Lunov et al.   BIOMATERIALS

Intracellular mechanisms of antigen cross presentation in dendritic cells

(2010) Sebastian Amigorena et al.   CURRENT OPINION IN IMMUNOLOGY

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Reprint of: Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation

(2010) Hidetaka Akita et al.   JOURNAL OF CONTROLLED RELEASE

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Properties of PEI-based Polyplex Nanoparticles That Correlate With Their Transfection Efficacy

(2010) Alexey V Ulasov et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Biodegradable polymeric nanoparticles based drug delivery systems

(2009) Avnesh Kumari et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Subcellular targeting strategies for drug design and delivery

(2009) Lawrence Rajendran et al.   NATURE REVIEWS DRUG DISCOVERY

Overexpression of mitochondrial cholesterol delivery protein, StAR, decreases intracellular lipids and inflammatory factors secretion in macrophages

(2008) Yanxia Ning et al.   ATHEROSCLEROSIS

Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness

(2008) H-Y Huang et al.   GENE THERAPY

The effect of particle design on cellular internalization pathways

(2008) S. E. A. Gratton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lentiviral-mediated GATA-3 RNAi Decreases Allergic Airway Inflammation and Hyperresponsiveness

(2007) Chen-Chen Lee et al.   MOLECULAR THERAPY