Hypoxia Selectively Impairs CAR-T Cells In Vitro

Les immunothérapies spécifiques dans le traitement des cancers

(2019) Hélène Denis et al.   BULLETIN DU CANCER

Engineering and Design of Chimeric Antigen Receptors

(2019) Sonia Guedan et al.   Molecular Therapy-Methods & Clinical Development

An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer

(2019) Steven Feins et al.   AMERICAN JOURNAL OF HEMATOLOGY

B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

(2019) Adam D. Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

CAR-T Cells Based on Novel BCMA Monoclonal Antibody Block Multiple Myeloma Cell Growth

(2018) Robert Berahovich et al.   Cancers

CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions

(2018) Wanghong Hu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1–2 trial

(2018) Frederick L Locke et al.   LANCET ONCOLOGY

FLAG-tagged CD19-specific CAR-T cells eliminate CD19-bearing solid tumor cells i in vitro i and i in vivo i

(2017) Vita M Golubovskaya   Frontiers in Bioscience-Landmark

Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma

(2017) Frederick L. Locke et al.   MOLECULAR THERAPY

The hypoxia signalling pathway in haematological malignancies

(2017) Marta Irigoyen et al.   Oncotarget

CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy

(2017) Nan Chen et al.   OncoImmunology

CD47-CAR-T Cells Effectively Kill Target Cancer Cells and Block Pancreatic Tumor Growth

(2017) Vita Golubovskaya et al.   Cancers

Most Do, but Some Do Not: CD4+CD25− T Cells, but Not CD4+CD25+ Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR)

(2017) Andreas Hombach et al.   Cancers

Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy

(2016) M. V. Maus et al.   CLINICAL CANCER RESEARCH

Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8 + and CD4 + CD19-specific chimeric antigen receptor–modified T cells

(2016) Cameron J. Turtle et al.   Science Translational Medicine

Phenotypic switch of CD8+T cells reactivated under hypoxia toward IL-10 secreting, poorly proliferative effector cells

(2015) Romain Vuillefroy de Silly et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effects of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes

(2015) Yohko Nakagawa et al.   IMMUNOLOGY LETTERS

Adoptive therapy with CAR redirected T cells: the challenges in targeting solid tumors

(2015) Hinrich Abken   Immunotherapy

The Emergence of T-Bodies/CAR T Cells

(2014) Zelig Eshhar et al.   CANCER JOURNAL

Hypoxia-inducible factors in regulation of immune responses in tumour microenvironment

(2014) Vinit Kumar et al.   IMMUNOLOGY

HIF-1 - and hypoxia-dependent immune responses in human CD4+CD25high T cells and T helper 17 cells

(2014) T. Bollinger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chimeric antigen receptor T cells are vulnerable to immunosuppressive mechanisms present within the tumor microenvironment

(2014) Gregory L Beatty et al.   OncoImmunology

Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+T cells and concomitantly impairs survival and proliferation

(2013) Timo Gaber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies

(2013) Marco L. Davila et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Signification et intérêt clinique de l’expression de PD-1 et PDL-1 dans les tumeurs

(2013) Cécile Badoual et al.   M S-MEDECINE SCIENCES

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamic regulation of Th17 differentiation by oxygen concentrations

(2011) A. Ikejiri et al.   INTERNATIONAL IMMUNOLOGY

MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1

(2011) Maimon E. Hubbi et al.   MOLECULAR CELL

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of HIF-1α and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells

(2009) Anis Larbi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

(2008) Carolina Berger et al.   JOURNAL OF CLINICAL INVESTIGATION