Mechanosensing through immunoreceptors

Unraveling the Mechanobiology of the Immune System

(2019) Jeong-Ki Kim et al.   Advanced Healthcare Materials

Cytoskeletal Control of Antigen-Dependent T Cell Activation

(2019) Huw Colin-York et al.   Cell Reports

Biphasic mechanosensitivity of T cell receptor-mediated spreading of lymphocytes

(2019) Astrid Wahl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition

(2019) Peng Wu et al.   MOLECULAR CELL

Imaging: Gear up for mechano-immunology

(2019) Zhengpeng Wan et al.   CELLULAR IMMUNOLOGY

PI(4,5)P2 determines the threshold of mechanical force–induced B cell activation

(2018) Zhengpeng Wan et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation

(2018) Chinky Shiu Chen Liu et al.   JOURNAL OF IMMUNOLOGY

Mechanics of antigen extraction in the B cell synapse

(2018) Katelyn M. Spillane et al.   MOLECULAR IMMUNOLOGY

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Control of Mechanotransduction by Molecular Clutch Dynamics

(2018) Alberto Elosegui-Artola et al.   TRENDS IN CELL BIOLOGY

αβ T Cell Receptor Mechanosensing Forces out Serial Engagement

(2018) Yinnian Feng et al.   TRENDS IN IMMUNOLOGY

Tunable molecular tension sensors reveal extension-based control of vinculin loading

(2018) Andrew S LaCroix et al.   eLife

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

(2018) Leah V. Sibener et al.   CELL

Molecular mechanisms of T cell sensitivity to antigen

(2018) Jesús A. Siller-Farfán et al.   IMMUNOLOGICAL REVIEWS

Mechanoimmunology: molecular-scale forces govern immune cell functions

(2018) Sophie V. Pageon et al.   MOLECULAR BIOLOGY OF THE CELL

Profiling the origin, dynamics, and function of traction force in B cell activation

(2018) Junyi Wang et al.   Science Signaling

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

(2018) Kristine N. Brazin et al.   IMMUNITY

A TCR mechanotransduction signaling loop induces negative selection in the thymus

(2018) Jinsung Hong et al.   NATURE IMMUNOLOGY

Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1

(2018) Nathan H. Roy et al.   Science Signaling

Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment

(2018) Gurpanna Saggu et al.   Nature Communications

Role of Mechanotransduction and Tension in T Cell Function

(2018) Jérémie Rossy et al.   Frontiers in Immunology

2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes

(2018) Elizabeth M. Kolawole et al.   Frontiers in Immunology

CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy

(2018) Monika C. Brunner-Weinzierl et al.   Frontiers in Immunology

Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases

(2017) Hiroshi Nishi et al.   JOURNAL OF CLINICAL INVESTIGATION

Receptor-mediated cell mechanosensing

(2017) Yunfeng Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Multiplexing molecular tension sensors reveals piconewton force gradient across talin-1

(2017) Pia Ringer et al.   NATURE METHODS

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

(2017) Wei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination

(2017) Rafal M. Pielak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanosensing drives acuity ofαβT-cell recognition

(2017) Yinnian Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation

(2017) Yun Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

Visualizing dynamic microvillar search and stabilization during ligand detection by T cells

(2017) En Cai et al.   SCIENCE

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Mechanosensing in the immune response

(2017) Arpita Upadhyaya   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanical Communication at the Immunological Synapse

(2017) Roshni Basu et al.   TRENDS IN CELL BIOLOGY

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions

(2017) Wei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

(2017) Samina Shaheen et al.   eLife

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

(2017) Michael Saitakis et al.   eLife

Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner

(2017) Jinsung Hong et al.   PLoS One

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands

(2016) Dibyendu Kumar Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse

(2016) Sricharan Murugesan et al.   JOURNAL OF CELL BIOLOGY

T cell activation requires force generation

(2016) Kenneth H. Hu et al.   JOURNAL OF CELL BIOLOGY

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

(2016) Katelyn M. Spillane et al.   JOURNAL OF CELL BIOLOGY

Ratiometric Tension Probes for Mapping Receptor Forces and Clustering at Intermembrane Junctions

(2016) Victor Pui-Yan Ma et al.   NANO LETTERS

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Initiation of T cell signaling by CD45 segregation at 'close contacts'

(2016) Veronica T Chang et al.   NATURE IMMUNOLOGY

Germinal center B cells recognize antigen through a specialized immune synapse architecture

(2016) Carla R Nowosad et al.   NATURE IMMUNOLOGY

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

(2016) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination

(2016) Sophie V. Pageon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of superresolution microscopies

(2016) Yunmin Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical Aspects of T Lymphocyte Activation at the Immune Synapse

(2016) Claire Hivroz et al.   Frontiers in Immunology

Action and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological Synapse

(2016) William A. Comrie et al.   Frontiers in Immunology

Molecular Force Spectroscopy on Cells

(2015) Baoyu Liu et al.   Annual Review of Physical Chemistry

The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex

(2015) Baoyu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Substrate stiffness regulates B-cell activation, proliferation, class switch, and T-cell-independent antibody responses in vivo

(2015) Yingyue Zeng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

(2015) Mark S. Lee et al.   IMMUNITY

Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+T Cells

(2015) Jinsung Hong et al.   JOURNAL OF IMMUNOLOGY

Lighting Up the Force: Investigating Mechanisms of Mechanotransduction Using Fluorescent Tension Probes

(2015) Carol Jurchenko et al.   MOLECULAR AND CELLULAR BIOLOGY

Cytoskeletal forces during signaling activation in Jurkat T-cells

(2015) King Lam Hui et al.   MOLECULAR BIOLOGY OF THE CELL

Pre-TCR ligand binding impacts thymocyte development before αβTCR expression

(2015) Robert J. Mallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Codification of bidentate pMHC interaction with TCR and its co-receptor

(2015) Ellis L. Reinherz et al.   TRENDS IN IMMUNOLOGY

The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

(2015) Zhengpeng Wan et al.   eLife

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

(2015) Kristine N. Brazin et al.   Frontiers in Immunology

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Mechanical regulation of T-cell functions

(2014) Wei Chen et al.   IMMUNOLOGICAL REVIEWS

Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells

(2014) S. Pryshchep et al.   JOURNAL OF IMMUNOLOGY

CD28 and CD3 have complementary roles in T-cell traction forces

(2014) Keenan T. Bashour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic catch of a Thy-1–α5β1+syndecan-4 trimolecular complex

(2014) Vincent F. Fiore et al.   Nature Communications

Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation

(2013) Yair Klieger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system

(2013) Baoyu Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B Cell Activation Is Regulated by the Stiffness Properties of the Substrate Presenting the Antigens

(2013) Z. Wan et al.   JOURNAL OF IMMUNOLOGY

Cross Talk between CD3 and CD28 Is Spatially Modulated by Protein Lateral Mobility

(2013) K. T. Bashour et al.   MOLECULAR AND CELLULAR BIOLOGY

Actin depolymerization under force is governed by lysine 113:glutamic acid 195-mediated catch-slip bonds

(2013) C.-y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Cells Use Mechanical Energy to Discriminate Antigen Affinities

(2013) E. Natkanski et al.   SCIENCE

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

(2013) Geoff P O'Donoghue et al.   eLife

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

Insights fromin situanalysis of TCR-pMHC recognition: response of an interaction network

(2012) Cheng Zhu et al.   IMMUNOLOGICAL REVIEWS

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Substrate Rigidity Regulates Human T Cell Activation and Proliferation

(2012) R. S. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

(2012) John R. James et al.   NATURE

T cell triggering: insights from 2D kinetics analysis of molecular interactions

(2012) Veronika Zarnitsyna et al.   PHYSICAL BIOLOGY

TCR Signaling Emerges from the Sum of Many Parts

(2012) Michael S. Kuhns et al.   Frontiers in Immunology

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

Rolling Cell Adhesion

(2010) Rodger P. McEver et al.   Annual Review of Cell and Developmental Biology

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

Structural Biology of the T-cell Receptor: Insights into Receptor Assembly, Ligand Recognition, and Initiation of Signaling

(2010) K. W. Wucherpfennig et al.   Cold Spring Harbor Perspectives in Biology

Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor

(2009) Travis Beddoe et al.   IMMUNITY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

(2009) Björn F Lillemeier et al.   NATURE IMMUNOLOGY

A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen

(2009) Omer Dushek et al.   PLoS Computational Biology

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY