Starved epithelial cells uptake extracellular matrix for survival

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

(2015) Ivan D Mascanfroni et al.   NATURE MEDICINE

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

(2015) Elena Rainero et al.   Cell Reports

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Endocytic trafficking of laminin is controlled by dystroglycan and is disrupted in cancers

(2014) D. Leonoudakis et al.   JOURNAL OF CELL SCIENCE

Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion

(2013) Elena Rainero et al.   BIOESSAYS

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells

(2012) Taru Muranen et al.   CANCER CELL

Distinct Recycling of Active and Inactive β1 Integrins

(2012) Antti Arjonen et al.   TRAFFIC

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

A microRNA network regulates proliferative timing and extracellular matrix synthesis during cellular quiescence in fibroblasts

(2012) Eric J Suh et al.   GENOME BIOLOGY

Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

(2011) Johanna Ivaska et al.   Annual Review of Cell and Developmental Biology

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

A Role for Drosophila dFoxO and dFoxO 5′UTR Internal Ribosomal Entry Sites during Fasting

(2010) Eugenia Villa-Cuesta et al.   PLoS One

Quiescent Fibroblasts Exhibit High Metabolic Activity

(2010) Johanna M. S. Lemons et al.   PLOS BIOLOGY

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Tumours with PI3K activation are resistant to dietary restriction

(2009) Nada Y. Kalaany et al.   NATURE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Anoikis: A necessary death program for anchorage-dependent cells

(2008) Paola Chiarugi et al.   BIOCHEMICAL PHARMACOLOGY

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

(2008) S.-M. Maira et al.   MOLECULAR CANCER THERAPEUTICS