Perspectives on immunometabolism at the biomaterials interface

Nano and Microparticle Emerging Strategies for Treatment of Autoimmune Diseases: Multiple Sclerosis and Type 1 Diabetes

(2020) Alexander J. Kwiatkowski et al.   Advanced Healthcare Materials

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

(2019) D. Scott Wilson et al.   NATURE MATERIALS

Dual-sized microparticle system generates suppressive dendritic cells, and prevents and reverses type 1 diabetes in the non-obese diabetic mouse

(2019) Jamal S Lewis et al.   ACS Biomaterials-Science & Engineering

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

(2019) Alanna M. Cameron et al.   NATURE IMMUNOLOGY

Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors

(2019) Kyung Hae Jung et al.   CLINICAL CANCER RESEARCH

Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation

(2019) Eiji Saito et al.   JOURNAL OF CONTROLLED RELEASE

The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair

(2019) Andrew S. Kimball et al.   IMMUNITY

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

(2019) Will Bailis et al.   NATURE

Treating ischemia via recruitment of antigen-specific T cells

(2019) Brian J. Kwee et al.   Science Advances

Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes

(2019) D. Scott Wilson et al.   Nature Biomedical Engineering

High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation

(2019) Dunfang Zhang et al.   IMMUNITY

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

ENERGIZE: a Phase III study of neoadjuvant chemotherapy alone or with nivolumab with/without linrodostat mesylate for muscle-invasive bladder cancer

(2019) Guru Sonpavde et al.   Future Oncology

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+Regulatory T Cells

(2018) Im-Hong Sun et al.   JOURNAL OF IMMUNOLOGY

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

(2018) Li Tang et al.   NATURE BIOTECHNOLOGY

Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models

(2018) Michael L Schulte et al.   NATURE MEDICINE

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

(2018) Asha Nayak-Kapoor et al.   Journal for ImmunoTherapy of Cancer

Macrophage response to hydrophilic biomaterials regulates MSC recruitment and T-helper cell populations

(2018) Kelly M. Hotchkiss et al.   BIOMATERIALS

The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling

(2018) Sara Ricciardi et al.   Cell Metabolism

Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer

(2018) Eric Fox et al.   Frontiers in Oncology

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Nanomaterial Interactions with Human Neutrophils

(2018) Paul W. Bisso et al.   ACS Biomaterials-Science & Engineering

Divergent immune responses to synthetic and biological scaffolds

(2018) Kaitlyn Sadtler et al.   BIOMATERIALS

The role of TGF-beta signaling in dendritic cell tolerance

(2017) Grace E. Esebanmen et al.   IMMUNOLOGIC RESEARCH

Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates

(2017) Joshua C. Doloff et al.   NATURE MATERIALS

Dendritic cells in the host response to implanted materials

(2017) Benjamin G. Keselowsky et al.   SEMINARS IN IMMUNOLOGY

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

(2017) Eddy W. Yue et al.   ACS Medicinal Chemistry Letters

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

RhoA orchestrates glycolysis for T H 2 cell differentiation and allergic airway inflammation

(2016) Jun-Qi Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immunometabolism of regulatory T cells

(2016) Ryan Newton et al.   NATURE IMMUNOLOGY

Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent

(2016) Lingling Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

(2016) K. Sadtler et al.   SCIENCE

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Metabolic requirements for neutrophil extracellular traps formation

(2015) Oscar Rodríguez-Espinosa et al.   IMMUNOLOGY

High Mitochondrial Respiration and Glycolytic Capacity Represent a Metabolic Phenotype of Human Tolerogenic Dendritic Cells

(2015) Frano Malinarich et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Responses to Sterile Implant Materials

(2015) Siddharth Jhunjhunwala et al.   PLoS One

Preventing Allograft Rejection by Targeting Immune Metabolism

(2015) Chen-Fang Lee et al.   Cell Reports

Characterization of porous, dexamethasone-releasing polyurethane coatings for glucose sensors

(2014) Suzana G. Vallejo-Heligon et al.   Acta Biomaterialia

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Mediate Blood–Spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases

(2014) Benoit Aubé et al.   JOURNAL OF IMMUNOLOGY

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2

(2013) Tavane D. Cambiaghi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion

(2013) Yared Hailemichael et al.   NATURE MEDICINE

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

L-Arginine Transport and Nitric Oxide Synthesis in Human Endothelial Progenitor Cells

(2012) Francisca Díaz-Pérez et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors

(2012) Krupa Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of vitamin D on antigen-specific and non-antigen-specific immune modulation: relevance for type 1 diabetes

(2012) Tatiana Takiishi et al.   PEDIATRIC DIABETES

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

(2012) Yutaka Kurebayashi et al.   Cell Reports

Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound

(2011) Michael F. Wempe et al.   Drug Metabolism and Pharmacokinetics

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

HIV Protease Inhibitors Act as Competitive Inhibitors of the Cytoplasmic Glucose Binding Site of GLUTs with Differing Affinities for GLUT1 and GLUT4

(2011) Richard C. Hresko et al.   PLoS One

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Extensive infiltration of neutrophils in the acute phase of experimental autoimmune encephalomyelitis in C57BL/6 mice

(2010) Fenglan Wu et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9

(2009) S. MacLauchlan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evaluation of SubstitutedN,N′-Diarylsulfonamides as Activators of the Tumor Cell Specific M2 Isoform of Pyruvate Kinase

(2009) Matthew B. Boxer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Infection-mimicking materials to program dendritic cells in situ

(2009) Omar A. Ali et al.   NATURE MATERIALS

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The foreign body reaction in T-cell-deficient mice

(2008) Analiz Rodriguez et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY

Vitronectin is a critical protein adhesion substrate for IL‐4‐induced foreign body giant cell formation

(2007) Amy K. McNally et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Interaction of dendritic cells with biomaterials

(2007) Julia E. Babensee   SEMINARS IN IMMUNOLOGY