Arginine depletion as a therapeutic approach for patients with COVID-19

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

A virus that has gone viral: amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding, and thus, infectivity

(2020) Priyanka Saha et al.   BIOSCIENCE REPORTS

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Comparative genome analysis of novel coronavirus (SARS-CoV-2) from different geographical locations and the effect of mutations on major target proteins: An in silico insight

(2020) Mohd Imran Khan et al.   PLoS One

Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR

(2017) Kristina L. Schierhorn et al.   JOURNAL OF VIROLOGY

Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways

(2016) Maria Dulfary Sanchez et al.   ANTIVIRAL RESEARCH

Arginine Metabolism Revisited

(2016) Sidney M Morris   JOURNAL OF NUTRITION

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma

(2015) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

(2015) Shiran Rabinovich et al.   NATURE

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

Inducible Nitric Oxide Contributes to Viral Pathogenesis Following Highly Pathogenic Influenza Virus Infection in Mice

(2013) Lucy A. Perrone et al.   JOURNAL OF INFECTIOUS DISEASES

Argininosuccinate synthetase 1 depletion produces a metabolic state conducive to herpes simplex virus 1 infection

(2013) S. L. Grady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

(2010) T-S Yang et al.   BRITISH JOURNAL OF CANCER

Arginine Deprivation as a Targeted Therapy for Cancer

(2008) L. Feun et al.   CURRENT PHARMACEUTICAL DESIGN