Metabolic reprogramming and cancer progression

The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters

(2019) Arnold J. Levine et al.   CANCER CELL

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

(2019) Grant M. Fischer et al.   Cancer Discovery

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation

(2019) Choong-kun Lee et al.   SCIENCE

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

(2019) Yufeng Shi et al.   NATURE

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

(2019) Ilaria Elia et al.   NATURE

High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells

(2019) Chun-Mei Hu et al.   Cell Metabolism

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

(2019) Christopher J. Halbrook et al.   Cell Metabolism

LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma

(2019) Ana Galan-Cobo et al.   CANCER RESEARCH

The landscape of cancer cell line metabolism

(2019) Haoxin Li et al.   NATURE MEDICINE

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

(2019) Jianing Xu et al.   eLife

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

(2019) Luca Lignitto et al.   CELL

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

(2019) Clotilde Wiel et al.   CELL

UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis

(2019) Xiongjun Wang et al.   NATURE

Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

(2019) Zhimin Gu et al.   Cancer Discovery

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

(2019) Romain Guièze et al.   CANCER CELL

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

(2019) Jiyeon Kim et al.   Cell Metabolism

Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1

(2019) Kristin L. Granlund et al.   Cell Metabolism

Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells

(2019) Pei-Hsuan Chen et al.   MOLECULAR CELL

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

(2019) Milica Momcilovic et al.   NATURE

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

(2019) David P. Labbé et al.   Nature Communications

Metabolic heterogeneity confers differences in melanoma metastatic potential

(2019) Alpaslan Tasdogan et al.   NATURE

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

(2018) Parker L. Sulkowski et al.   NATURE GENETICS

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells

(2018) Seong M. Kim et al.   Cancer Discovery

Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer

(2018) Rong Zhou et al.   CANCER RESEARCH

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

(2018) Samuel K. McBrayer et al.   CELL

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

(2018) Maria Apicella et al.   Cell Metabolism

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

(2018) Benjamin D. Hopkins et al.   NATURE

Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer

(2018) Marcus D. Goncalves et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma

(2018) Claudio R. Scafoglio et al.   Science Translational Medicine

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells

(2017) Jiyeon Kim et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma

(2016) Changho Choi et al.   JOURNAL OF CLINICAL ONCOLOGY

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis

(2016) Filippos Kottakis et al.   NATURE

Body Fatness and Cancer — Viewpoint of the IARC Working Group

(2016) Béatrice Lauby-Secretan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

(2016) Geou-Yarh Liou et al.   Cell Reports

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Immunohistochemical Loss of LKB1 Is a Biomarker for More Aggressive Biology in KRAS-Mutant Lung Adenocarcinoma

(2015) A. Calles et al.   CLINICAL CANCER RESEARCH

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

(2015) Sriram Venneti et al.   Science Translational Medicine

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

(2015) Charlotte Lussey-Lepoutre et al.   Nature Communications

Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

(2015) F. Skoulidis et al.   Cancer Discovery

The landscape of metastatic progression patterns across major human cancers

(2015) Jan Budczies et al.   Oncotarget

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Origins of Metastatic Traits

(2013) Sakari Vanharanta et al.   CANCER CELL

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

(2013) Irène Baccelli et al.   NATURE BIOTECHNOLOGY

Tumor metastasis: moving new biological insights into the clinic

(2013) Liling Wan et al.   NATURE MEDICINE

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate

(2013) S. J. Nelson et al.   Science Translational Medicine

Metabolic and Functional Genomic Studies Identify Deoxythymidylate Kinase as a Target in LKB1-Mutant Lung Cancer

(2013) Y. Liu et al.   Cancer Discovery

A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

(2013) Julie Adam et al.   Cell Reports

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

(2012) Zhao Chen et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression

(2011) Simon Hu et al.   Cell Metabolism

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

(2011) Christian Frezza et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

(2011) H Zhang et al.   ONCOGENE

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Isolation and Characterization of Circulating Tumor Cells from Patients with Localized and Metastatic Prostate Cancer

(2010) S. L. Stott et al.   Science Translational Medicine

Detection of Metabolic Alterations in Non-tumor Gastrointestinal Tissue of theApcMin/+Mouse by1H MAS NMR Spectroscopy

(2009) Alexandra Backshall et al.   JOURNAL OF PROTEOME RESEARCH

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Subtypes of Breast Cancer Show Preferential Site of Relapse

(2008) M. Smid et al.   CANCER RESEARCH

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Transmission of Glioblastoma Multiforme After Bilateral Lung Transplantation

(2008) Hongbin Chen et al.   JOURNAL OF CLINICAL ONCOLOGY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE