Engineering the lymph node environment promotes antigen-specific efficacy in type 1 diabetes and islet transplantation

Exploiting Rational Assembly to Map Distinct Roles of Regulatory Cues during Autoimmune Therapy

(2021) Robert S. Oakes et al.   ACS Nano

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals

(2021) Emily K. Sims et al.   Science Translational Medicine

Biophysical Properties of Self-Assembled Immune Signals Impact Signal Processing and the Nature of Regulatory Immune Function

(2021) Eugene Froimchuk et al.   NANO LETTERS

Intralymphatic immunotherapy for allergic rhinitis: A systematic review and meta-analysis

(2021) Michael T. Werner et al.   ALLERGY AND ASTHMA PROCEEDINGS

Long-Term Survival after Kidney Transplantation

(2021) Sundaram Hariharan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes

(2021) Fritz Cayabyab et al.   Frontiers in Endocrinology

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

(2020) Lars Fugger et al.   CELL

The lymph node stromal laminin α5 shapes alloimmunity

(2020) Lushen Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutamic Acid Decarboxylase Injection Into Lymph Nodes: Beta Cell Function and Immune Responses in Recent Onset Type 1 Diabetes Patients

(2020) Rosaura Casas et al.   Frontiers in Immunology

Modulating lung immune cells by pulmonary delivery of antigen-specific nanoparticles to treat autoimmune disease

(2020) Eiji Saito et al.   Science Advances

Tolerogenic nanoparticles suppress central nervous system inflammation

(2020) Jessica E. Kenison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Immune Tolerance with Biomaterials

(2019) Joshua M. Gammon et al.   Advanced Healthcare Materials

Compartmentalized gut lymph node drainage dictates adaptive immune responses

(2019) Daria Esterházy et al.   NATURE

Cardiovascular Risk in Type 1 Diabetes Mellitus

(2019) Jonathan Schofield et al.   Diabetes Therapy

Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model

(2019) Sahil Shah et al.   BIOMATERIALS

An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes

(2019) Kevan C. Herold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential Regulation of T Cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node

(2019) Thomas Simon et al.   TRANSPLANTATION

Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes

(2019) D. Scott Wilson et al.   Nature Biomedical Engineering

Long‐term outcome of islet transplantation on insulin‐dependent diabetes mellitus: An observational cohort study

(2019) Toshihiro Nakamura et al.   Journal of Diabetes Investigation

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+Regulatory T Cells

(2018) Im-Hong Sun et al.   JOURNAL OF IMMUNOLOGY

Designing natural and synthetic immune tissues

(2018) Emily A. Gosselin et al.   NATURE MATERIALS

Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis

(2018) Robert A. LaMothe et al.   Frontiers in Immunology

Regulatory T cells in the treatment of disease

(2018) Amir Sharabi et al.   NATURE REVIEWS DRUG DISCOVERY

Low-dose controlled release of mTOR inhibitors maintains T cell plasticity and promotes central memory T cells

(2017) Joshua M. Gammon et al.   JOURNAL OF CONTROLLED RELEASE

Innate Control of Adaptive Immunity: Beyond the Three-Signal Paradigm

(2017) Aakanksha Jain et al.   JOURNAL OF IMMUNOLOGY

Intralymphatic Injection of Autoantigen in Type 1 Diabetes

(2017) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of the Immune System by Laminins

(2017) Thomas Simon et al.   TRENDS IN IMMUNOLOGY

Design of Polyelectrolyte Multilayers to Promote Immunological Tolerance

(2016) Lisa H. Tostanoski et al.   ACS Nano

Targeted Programming of the Lymph Node Environment Causes Evolution of Local and Systemic Immunity

(2016) James I. Andorko et al.   Cellular and Molecular Bioengineering

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

(2016) Lisa H. Tostanoski et al.   Cell Reports

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

(2015) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Lymph Node Stromal Fiber ER-TR7 Modulates CD4+ T Cell Lymph Node Trafficking and Transplant Tolerance

(2015) Bryna E. Burrell et al.   TRANSPLANTATION

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Laminins affect T cell trafficking and allograft fate

(2014) Kristi J. Warren et al.   JOURNAL OF CLINICAL INVESTIGATION

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

(2014) D. R. Getts et al.   Science Translational Medicine

Intra-lymph Node Injection of Biodegradable Polymer Particles

(2014) James I. Andorko et al.   Jove-Journal of Visualized Experiments

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

(2012) S. Kontos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intra-Lymph Node Prime-Boost Vaccination against Melan A and Tyrosinase for the Treatment of Metastatic Melanoma: Results of a Phase 1 Clinical Trial

(2011) A. Ribas et al.   CLINICAL CANCER RESEARCH

In vivobiodistribution of nanoparticles

(2011) Joao Paulo Mattos Almeida et al.   Nanomedicine

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

(2011) C. M. Jewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Teplizumab therapy for type 1 diabetes

(2010) Umesh B Masharani et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation

(2010) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry

(2009) L. Gattinoni et al.   Science Translational Medicine

Antigen kinetics determines immune reactivity

(2008) Pål Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial

(2008) G. Senti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA