NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson’s Disease

The CD38 glycohydrolase and the NAD sink: implications for pathological conditions

(2022) Julianna D. Zeidler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Low dose 1,3-butanediol reverses age-associated vascular dysfunction independent of ketone body β-hydroxybutyrate

(2022) Cameron G. McCarthy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

(2022) Shogo Sato et al.   Cell Metabolism

Spatial and temporal control of mitochondrial H 2 O 2 release in intact human cells

(2022) Michaela Nicole Hoehne et al.   EMBO JOURNAL

Time‐restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle

(2022) Paul Goede et al.   FASEB JOURNAL

Cellular senescence: all roads lead to mitochondria

(2022) Hélène Martini et al.   FEBS Journal

Sleep and circadian rhythms in Parkinson’s disease and preclinical models

(2022) Jeremy Hunt et al.   Molecular Neurodegeneration

Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging

(2022) Jinoh Kim et al.   Antioxidants

Mitochondrial DNA homeostasis impairment and dopaminergic dysfunction: A trembling balance

(2022) Arianna Manini et al.   AGEING RESEARCH REVIEWS

A systems-approach to NAD+ restoration

(2022) Nichola Conlon et al.   BIOCHEMICAL PHARMACOLOGY

The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases

(2022) Liliana M. Almeida et al.   BIOLOGICAL REVIEWS

The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease

(2022) Brage Brakedal et al.   Cell Metabolism

ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress

(2022) Xiaoding Wang et al.   CIRCULATION RESEARCH

Physical Activity Rewires the Human Brain against Neurodegeneration

(2022) Jose A. Santiago et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Proteins Unveil the Mechanism by Which Physical Exercise Ameliorates Memory, Learning and Motor Activity in Hypoxic Ischemic Encephalopathy Rat Model

(2022) Fred Gendi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interventions to improve gait in Parkinson’s disease: a systematic review of randomized controlled trials and network meta-analysis

(2022) Victor Schwartz Hvingelby et al.   JOURNAL OF NEUROLOGY

Mitochondrial quality control in health and in Parkinson's disease

(2022) Mohamed A. Eldeeb et al.   PHYSIOLOGICAL REVIEWS

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

(2022) Victoria Acosta-Rodríguez et al.   SCIENCE

FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice

(2022) Cristal M. Hill et al.   Nature Communications

Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration

(2022) Verena Kluever et al.   Science Advances

IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system

(2022) Anjaneyulu Murari et al.   Science Advances

Effects of Ten Different Exercise Interventions on Motor Function in Parkinson’s Disease Patients—A Network Meta-Analysis of Randomized Controlled Trials

(2022) Zikang Hao et al.   Brain Sciences

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

(2022) Hongxu Xian et al.   IMMUNITY

Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation

(2022) Charline Mary et al.   MOLECULAR CELL

Structure of human NADK2 reveals atypical assembly and regulation of NAD kinases from animal mitochondria

(2022) Jin Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G6PD-mediated increase in de novo NADP + biosynthesis promotes antioxidant defense and tumor metastasis

(2022) Yang Zhang et al.   Science Advances

Ketogenic therapy for Parkinson's disease: A systematic review and synthesis without meta-analysis of animal and human trials

(2022) Maria G. Grammatikopoulou et al.   MATURITAS

Regulation of diurnal energy balance by mitokines

(2021) Susanne Klaus et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial proteases in human diseases

(2021) Maria Gomez‐Fabra Gala et al.   FEBS LETTERS

Roles of HDAC3-orchestrated circadian clock gene oscillations in diabetic rats following myocardial ischaemia/reperfusion injury

(2021) Zhen Qiu et al.   Cell Death & Disease

Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms

(2021) Xiangpeng Ren et al.   Frontiers in Neuroscience

Regulation of PRKN-independent mitophagy

(2021) Petra Terešak et al.   Autophagy

Exercise rescues mitochondrial coupling in aged skeletal muscle: a comparison of different modalities in preventing sarcopenia

(2021) Colin Harper et al.   Journal of Translational Medicine

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

(2021) Margaret E Torrence et al.   eLife

Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents

(2021) Wei Yao et al.   Translational Psychiatry

Parkinson's disease and mitophagy: an emerging role for LRRK2

(2021) Francois Singh et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson’s disease? A critical reappraisal

(2021) Nitya Subrahmanian et al.   BRAIN RESEARCH

Histone deacetylase 3 inhibition alleviates type 2 diabetes mellitus-induced endothelial dysfunction via Nrf2

(2021) Shuai Huang et al.   Cell Communication and Signaling

The cell biology of Parkinson’s disease

(2021) Nikhil Panicker et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial NADP(H) generation is essential for proline biosynthesis

(2021) Jiajun Zhu et al.   SCIENCE

Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress

(2021) Inna Rabinovich-Nikitin et al.   Autophagy

Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity

(2021) Vaishali Jayashankar et al.   EMBO Molecular Medicine

The molecular signature of high-intensity interval training in the human body

(2021) Patrick Wahl et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Long-lived mitochondrial cristae proteins in mouse heart and brain

(2021) Ewa Bomba-Warczak et al.   JOURNAL OF CELL BIOLOGY

The balance between NAD+ biosynthesis and consumption in ageing

(2021) Øyvind Strømland et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Identification of sixteen novel candidate genes for late onset Parkinson’s disease

(2021) Alessandro Gialluisi et al.   Molecular Neurodegeneration

Molecular mechanisms of dietary restriction promoting health and longevity

(2021) Cara L. Green et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway

(2021) Huiqing Wang et al.   NEUROPEPTIDES

Nutritional Ketosis in Parkinson’s Disease — a Review of Remaining Questions and Insights

(2021) Alexander Choi et al.   Neurotherapeutics

Interactions of Lipids, Lipoproteins, and Apolipoproteins with the Blood-Brain Barrier

(2021) Elizabeth M. Rhea et al.   PHARMACEUTICAL RESEARCH

NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission

(2021) Mukesh Mahajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

(2021) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation

(2021) Kevin B. Koronowski et al.   Cell Reports

Exercise-Induced Lactate Release Mediates Mitochondrial Biogenesis in the Hippocampus of Mice via Monocarboxylate Transporters

(2021) Jonghyuk Park et al.   Frontiers in Physiology

NAD+ flux is maintained in aged mice despite lower tissue concentrations

(2021) Melanie R. McReynolds et al.   Cell Systems

Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson’s Disease Models

(2021) Dinesh Kumar Verma et al.   Cells

Roles of clock genes in the pathogenesis of Parkinson's disease

(2021) Anastasiia Dmytrivna Shkodina et al.   AGEING RESEARCH REVIEWS

Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain

(2021) Shefali Krishna et al.   DEVELOPMENTAL CELL

Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing

(2021) Ole Kristian Reiten et al.   MECHANISMS OF AGEING AND DEVELOPMENT

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

(2021) Ying Wang et al.   NATURE

Polyphosphate-dependent nicotinamide adenine dinucleotide (NAD) kinase: A novel missing link in human mitochondria

(2021) Kousaku MURATA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Age-Dependent Decline of NAD+—Universal Truth or Confounded Consensus?

(2021) Augusto Peluso et al.   Nutrients

Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine

(2021) Christopher J. Terranova et al.   Cell Reports

6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

(2021) Saeed Daneshmandi et al.   eLife

α-Ketoglutarate Inhibits Thrombosis and Inflammation by Prolyl Hydroxylase-2 Mediated Inactivation of Phospho-Akt

(2021) Nishith M Shrimali et al.   EBioMedicine

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

(2021) Arati Tripathi et al.   Biomolecules

ROS-Induced mtDNA Release: The Emerging Messenger for Communication between Neurons and Innate Immune Cells during Neurodegenerative Disorder Progression

(2021) Yuanxin Zhao et al.   Antioxidants

Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway

(2020) Igor Shats et al.   Cell Metabolism

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

(2020) Naoya Yamada et al.   Cell Death & Disease

Improvement of Blood Plasmalogens and Clinical Symptoms in Parkinson’s Disease by Oral Administration of Ether Phospholipids: A Preliminary Report

(2020) Shiro Mawatari et al.   Parkinsons Disease

Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson’s Disease

(2020) Alexandre Vallée et al.   Cells

Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

(2020) Donald A. Lamb et al.   Aging-US

BMAL1 regulation of microglia‐mediated neuroinflammation in MPTP‐induced Parkinson's disease mouse model

(2020) Wen‐Wen Liu et al.   FASEB JOURNAL

Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson’s Disease

(2020) Mark F. McCarty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatic NADH reductive stress underlies common variation in metabolic traits

(2020) Russell P. Goodman et al.   NATURE

Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells

(2020) Marcos A. Perez et al.   DEVELOPMENTAL CELL

Cerebrospinal and blood levels of amino acids as potential biomarkers for Parkinson’s Disease: review and meta‐analysis

(2020) Félix Javier Jiménez‐Jiménez et al.   EUROPEAN JOURNAL OF NEUROLOGY

Mitochondrial NAD(P)+ Transhydrogenase is Unevenly Distributed in Different Brain Regions, and its Loss Causes Depressive-like Behavior and Motor Dysfunction in Mice

(2020) Annelise Francisco et al.   NEUROSCIENCE

Autonomic Dysfunction in Parkinson’s Disease

(2020) Ronald F. Pfeiffer   Neurotherapeutics

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

(2020) Azar Asadi Shahmirzadi et al.   Cell Metabolism

Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease

(2020) Laura M. Butkovich et al.   JOURNAL OF NEUROSCIENCE

Orexin and Parkinson's disease: A protective neuropeptide with therapeutic potential

(2020) Cui Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance

(2020) Oeystein Roed Brekk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral Glycolysis in Neurodegenerative Diseases

(2020) Simon M. Bell et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NAD+ metabolism and its roles in cellular processes during ageing

(2020) Anthony J. Covarrubias et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Potential Roles of Exercise-Induced Plasma Metabolites Linking Exercise to Health Benefits

(2020) Yong Ryoul Yang et al.   Frontiers in Physiology

The “great” controlling nucleotide coenzymes

(2019) Richard L. Veech et al.   IUBMB LIFE

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase

(2019) Gerta Hoxhaj et al.   SCIENCE

Peroxisomal dysfunction in neurodegenerative diseases

(2019) Doo Sin Jo et al.   ARCHIVES OF PHARMACAL RESEARCH

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

(2019) Ludmila P. Dolgacheva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Lipid Metabolism Crosstalk in the Brain: Glia and Neurons

(2019) Casey N. Barber et al.   Frontiers in Cellular Neuroscience

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

(2019) Yuan Su et al.   Aging-US

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases

(2019) Rong Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4

(2019) Salil Saurav Pathak et al.   NEURON

Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria

(2019) Eisha Shaw et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease

(2019) Sandra Torres et al.   Frontiers in Neurology

Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner

(2018) Avigail T. Erlich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

(2018) Ling Liu et al.   Cell Metabolism

The Homeostatic Force of Ghrelin

(2018) Shigehisa Yanagi et al.   Cell Metabolism

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

(2018) Karen Schmitt et al.   Cell Metabolism

Cytochromecis an oxidative stress–activated plasmalogenase that cleaves plasmenylcholine and plasmenylethanolamine at thesn-1 vinyl ether linkage

(2018) Christopher M. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism

(2018) Russell P. Goodman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian rhythms in mitochondrial respiration

(2018) Paul de Goede et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress

(2018) Shaoqing Xu et al.   JOURNAL OF NEUROCHEMISTRY

Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies

(2018) Jose-Alberto Palma et al.   MOVEMENT DISORDERS

Intermittent metabolic switching, neuroplasticity and brain health

(2018) Mark P. Mattson et al.   NATURE REVIEWS NEUROSCIENCE

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

(2018) Laurent Perrin et al.   eLife

Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

(2018) Sarah J. Mitchell et al.   Cell Metabolism

Disruption of the Superoxide Anions-Mitophagy Regulation Axis Mediates Copper Oxide Nanoparticles-Induced Vascular Endothelial Cell Death

(2018) Jun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiolipin Profile Changes are Associated to the Early Synaptic Mitochondrial Dysfunction in Alzheimer's Disease

(2018) Vera F. Monteiro-Cardoso et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control

(2018) Shuya Kasai et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

High-intensity interval training in people with Parkinson’s disease: a randomized, controlled feasibility trial

(2018) Marguerite Harvey et al.   CLINICAL REHABILITATION

Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats

(2018) Huan Li et al.   NEUROTOXICITY RESEARCH

Can high-intensity interval training change cardiac autonomic control? A systematic review

(2018) Raphael Martins de Abreu et al.   Brazilian Journal of Physical Therapy

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease

(2017) Robert J. Pawlosky et al.   JOURNAL OF NEUROCHEMISTRY

The pharmacological regulation of cellular mitophagy

(2017) Nikolaos D Georgakopoulos et al.   Nature Chemical Biology

Ketone Bodies as Anti-Seizure Agents

(2017) Timothy A. Simeone et al.   NEUROCHEMICAL RESEARCH

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

(2017) Thomas Misgeld et al.   NEURON

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

(2017) Svetlana Di Benedetto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Dopamine: A Modulator of Circadian Rhythms in the Central Nervous System

(2017) Kirill S. Korshunov et al.   Frontiers in Cellular Neuroscience

Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria

(2017) Bin Xiao et al.   Cell Death & Disease

Novel histone deacetylase inhibitor N25 exerts anti-tumor effects and induces autophagy in human glioma cells by inhibiting HDAC3

(2017) Xin-yuan Sun et al.   Oncotarget

Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

(2017) Muheeb Beg et al.   eLife

Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?

(2017) Marwa Elamin et al.   Frontiers in Molecular Neuroscience

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice

(2017) Shinichi Someya et al.   PLoS One

Unravelling the mechanisms regulating muscle mitochondrial biogenesis

(2016) D. A. Hood et al.   BIOCHEMICAL JOURNAL

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Glucagon action in the brain

(2016) Mona A. Abraham et al.   DIABETOLOGIA

The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress

(2016) Shaon Sengupta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Investigating mitochondrial redox state using NADH and NADPH autofluorescence

(2016) Thomas S. Blacker et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mediators of Physical Activity on Neurocognitive Function: A Review at Multiple Levels of Analysis

(2016) Chelsea M. Stillman et al.   Frontiers in Human Neuroscience

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

(2016) Krisztina Marosi et al.   JOURNAL OF NEUROCHEMISTRY

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

(2016) Christian Dölle et al.   Nature Communications

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity

(2016) Dirk van Moorsel et al.   Molecular Metabolism

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

The life-extending effect of dietary restriction requires Foxo3 in mice

(2015) Isao Shimokawa et al.   AGING CELL

Circadian clock genes: Effects on dopamine, reward and addiction

(2015) Puja K. Parekh et al.   ALCOHOL

Mitochondrial quality control: Easy come, easy go

(2015) Aleksandr Stotland et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

(2015) David Jacobi et al.   Cell Metabolism

Redox Homeostasis and Mitochondrial Dynamics

(2015) Peter H.G.M. Willems et al.   Cell Metabolism

The iPLA2γ is identified as the membrane potential sensitive phospholipase in liver mitochondria

(2015) Adam J. Rauckhorst et al.   FEBS LETTERS

Parkinson's disease and intensive exercise therapy – a systematic review and meta-analysis of randomized controlled trials

(2015) Anders Uhrbrand et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study

(2015) Mike A Nalls et al.   LANCET NEUROLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain

(2015) Ai-Ling Lin et al.   NEUROBIOLOGY OF AGING

Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis

(2015) Jennifer T. Lamberts et al.   NEUROBIOLOGY OF DISEASE

Predicted Role of NAD Utilization in the Control of Circadian Rhythms during DNA Damage Response

(2015) Augustin Luna et al.   PLoS Computational Biology

Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons

(2014) Debolina Ghosh et al.   AGING CELL

ATF4 activity: a common feature shared by many kinds of slow-aging mice

(2014) Weiquan Li et al.   AGING CELL

AMPK agonist AICAR improves cognition and motor coordination in young and aged mice

(2014) T. Kobilo et al.   LEARNING & MEMORY

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Circadian insights into dopamine mechanisms

(2014) J. Mendoza et al.   NEUROSCIENCE

Exacerbated oxidative stress in the fasting liver according to fuel partitioning

(2014) Thierry Wasselin et al.   PROTEOMICS

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress

(2014) Xiao-shan Wan et al.   Biomed Research International

Fatty Acids in Energy Metabolism of the Central Nervous System

(2014) Alexander Panov et al.   Biomed Research International

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

(2014) David P. Breen et al.   JAMA Neurology

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease

(2014) Elena N. Dedkova et al.   Frontiers in Physiology

Structural determinants of the hydrogen peroxide permeability of aquaporins

(2013) Abdulnasser Almasalmeh et al.   FEBS Journal

A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities

(2013) Juliana A. Ronchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotective effects of alpha-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine exposure in mice

(2013) R. Satpute et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

The ATP Costs and Time Required to Degrade Ubiquitinated Proteins by the 26 S Proteasome

(2013) Andreas Peth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice

(2013) Ying Dai et al.   MITOCHONDRION

Primary sleep disorder prevalence in patients with newly diagnosed Parkinson's disease

(2013) Benjamin Prudon et al.   MOVEMENT DISORDERS

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

BDNF and Exercise Enhance Neuronal DNA Repair by Stimulating CREB-Mediated Production of Apurinic/Apyrimidinic Endonuclease 1

(2013) Jenq-Lin Yang et al.   NEUROMOLECULAR MEDICINE

AMPK activation regulates neuronal structure in developing hippocampal neurons

(2013) S. Ramamurthy et al.   NEUROSCIENCE

Assessing Phospholipase A2 Activity toward Cardiolipin by Mass Spectrometry

(2013) Yuan-Hao Hsu et al.   PLoS One

Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans

(2013) Kook Hwan Kim et al.   PLoS One

BDNF mediates adaptive brain and body responses to energetic challenges

(2013) Krisztina Marosi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway

(2012) I-Chen Peng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Implication of Nrf2 and ATF4 in differential induction of CHOP by proteasome inhibition in thyroid cancer cells

(2012) Zhi-Hong Zong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue

(2012) A. Galmozzi et al.   DIABETES

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

(2012) Robert C. Stanton   IUBMB LIFE

Stimulation of Histone Deacetylase Activity by Metabolites of Intermediary Metabolism

(2012) Maria Vogelauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Reversible Early Oxidized Redox State That Precedes Macromolecular ROS Damage in Aging Nontransgenic and 3xTg-AD Mouse Neurons

(2012) D. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Physiological adaptations to low-volume, high-intensity interval training in health and disease

(2012) Martin J. Gibala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exercise induces mitochondrial biogenesis after brain ischemia in rats

(2012) Q. Zhang et al.   NEUROSCIENCE

Skeletal muscle transcriptional coactivator PGC-1  mediates mitochondrial, but not metabolic, changes during calorie restriction

(2012) L. W. S. Finley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability

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