Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity

The STEP 1 trial for weight loss: a step change in treating obesity?

(2021) Amanda I. Adler   NATURE MEDICINE

Drug Therapy in Obesity: A Review of Current and Emerging Treatments

(2020) David M. Williams et al.   Diabetes Therapy

Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1

(2020) Wesley Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin-2 in nucleus accumbens regulates anxiety and depression-like behaviors through mitochondrial and neuronal actions

(2020) Elias Gebara et al.   BIOLOGICAL PSYCHIATRY

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

(2020) Alison E. Ringel et al.   CELL

Perphenazine exerts antitumor effects on HUT78 cells through Akt dephosphorylation by protein phosphatase 2A

(2020) Shunya Tsuji et al.   Oncology Letters

Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight

(2019) Giacomo Mancini et al.   Cell Reports

Adiponectin-leptin Ratio is a Functional Biomarker of Adipose Tissue Inflammation

(2019) Gema Frühbeck et al.   Nutrients

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity

(2019) Philipp Hammerschmidt et al.   CELL

Leptin resensitisation: a reversion of leptin-resistant states

(2019) María F Andreoli et al.   JOURNAL OF ENDOCRINOLOGY

Mitochondria‐Mediated Pathogenesis and Therapeutics for Non‐Alcoholic Fatty Liver Disease

(2019) Zheng Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis

(2019) Bhagirath Chaurasia et al.   SCIENCE

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

(2019) Sarbajeet Nagdas et al.   Cell Reports

Mitochondrial Dynamics and Its Involvement in Disease

(2019) David C. Chan   Annual Review of Pathology-Mechanisms of Disease

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

(2019) Ke-qi Fan et al.   CELL

Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy

(2019) Shangang Zhao et al.   Cell Metabolism

Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6

(2018) Brendan T. Finicle et al.   JOURNAL OF CELL SCIENCE

Control of hyperglycemia in male mice by leflunomide: mechanisms of action

(2018) Junhong Chen et al.   JOURNAL OF ENDOCRINOLOGY

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Dynamin-Related Protein 1 at the Crossroads of Cancer

(2018) Ana Rita Lima et al.   Genes

Progress and challenges in anti-obesity pharmacotherapy

(2018) Daniel H Bessesen et al.   Lancet Diabetes & Endocrinology

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

(2018) Nigel Turner et al.   Nature Communications

Dynamic phosphoproteomics uncovers signaling pathways modulated by anti-neoplastic sphingolipid analogs

(2018) Peter Kubiniok et al.   MOLECULAR & CELLULAR PROTEOMICS

MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo

(2018) Erol C. Bayraktar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of mitochondrial homeostasis by endocytic regulatory proteins

(2017) Trey Farmer et al.   JOURNAL OF CELL SCIENCE

Current pharmacotherapy for obesity

(2017) Gitanjali Srivastava et al.   Nature Reviews Endocrinology

High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission

(2017) Nada Abuarab et al.   Science Signaling

Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action

(2017) Beatrice M. Filippi et al.   Cell Reports

Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

(2017) Nuno Rocha et al.   eLife

High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission

(2017) Nada Abuarab et al.   Science Signaling

Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk

(2017) Gema Frühbeck et al.   Adipocyte

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus

(2016) Kenneth Cusi et al.   ANNALS OF INTERNAL MEDICINE

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

(2016) Joel T. Haas et al.   Annual Review of Physiology

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Regulators of mitochondrial dynamics in cancer

(2016) Daniela Senft et al.   CURRENT OPINION IN CELL BIOLOGY

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

(2016) Seong M. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy

(2016) B. A. Ayanga et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice

(2016) Jaemin Lee et al.   NATURE MEDICINE

Targeting adipose tissue in the treatment of obesity-associated diabetes

(2016) Christine M. Kusminski et al.   NATURE REVIEWS DRUG DISCOVERY

Bariatric surgery for obesity and metabolic disorders: state of the art

(2016) Ninh T. Nguyen et al.   Nature Reviews Gastroenterology & Hepatology

Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

(2016) Stephanie Kullmann et al.   PHYSIOLOGICAL REVIEWS

Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells

(2016) Suman Suman et al.   Oncotarget

Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo

(2015) Bin Chen et al.   ACS Chemical Biology

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

(2015) David Jacobi et al.   Cell Metabolism

Effect of pioglitazone on plasma ceramides in adults with metabolic syndrome

(2015) Jeremy T. Warshauer et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration

(2015) Lixiang Wang et al.   DIABETOLOGIA

Circulating adiponectin, leptin and adiponectin-leptin ratio and endometrial cancer risk: Evidence from a meta-analysis of epidemiologic studies

(2015) Ting-Ting Gong et al.   INTERNATIONAL JOURNAL OF CANCER

Patchy progress on obesity prevention: emerging examples, entrenched barriers, and new thinking

(2015) Christina A Roberto et al.   LANCET

Sphingolipids in High Fat Diet and Obesity-Related Diseases

(2015) Songhwa Choi et al.   MEDIATORS OF INFLAMMATION

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

(2015) Madhavika N. Serasinghe et al.   MOLECULAR CELL

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis

(2015) Hiroshi Tsugawa et al.   NATURE METHODS

Mitochondrial control by DRP1 in brain tumor initiating cells

(2015) Qi Xie et al.   NATURE NEUROSCIENCE

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

(2015) P. Katajisto et al.   SCIENCE

Decreasing mitochondrial fission alleviates hepatic steatosis in a murine model of nonalcoholic fatty liver disease

(2014) Chad A. Galloway et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity and cancer—mechanisms underlying tumour progression and recurrence

(2014) Jiyoung Park et al.   Nature Reviews Endocrinology

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

(2014) S. Y. Yau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle

(2013) Melissa E. Smith et al.   BIOCHEMICAL JOURNAL

The adipokine/ceramide axis: Key aspects of insulin sensitization

(2013) Jonathan Y. Xia et al.   BIOCHIMIE

Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine

(2013) Itsuo MURAKAMI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids

(2013) Sarah K. Abbott et al.   LIPIDS

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

(2013) Miki Okada-Iwabu et al.   NATURE

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial dynamics and morphology in beta-cells

(2012) Linsey Stiles et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Adiponectin: mechanistic insights and clinical implications

(2012) A. T. Turer et al.   DIABETOLOGIA

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

(2012) X. Qi et al.   JOURNAL OF CELL SCIENCE

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in white adipose tissue

(2012) Christine M. Kusminski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Serum Lipidomics Profiling Using LC–MS and High-Energy Collisional Dissociation Fragmentation: Focus on Triglyceride Detection and Characterization

(2011) Susan S. Bird et al.   ANALYTICAL CHEMISTRY

The global obesity pandemic: shaped by global drivers and local environments

(2011) Boyd A Swinburn et al.   LANCET

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity

(2011) Z. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Pioglitazone in the treatment of NASH: the role of adiponectin

(2010) A. Gastaldelli et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Enhanced Metabolic Flexibility Associated with Elevated Adiponectin Levels

(2010) Ingrid Wernstedt Asterholm et al.   AMERICAN JOURNAL OF PATHOLOGY

Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry

(2010) Takhar Kasumov et al.   ANALYTICAL BIOCHEMISTRY

Mechanisms of adiponectin regulation and use as a pharmacological target

(2010) Susan A Phillips et al.   CURRENT OPINION IN PHARMACOLOGY

The effect of dietary phytosphingosine on cholesterol levels and insulin sensitivity in subjects with the metabolic syndrome

(2010) M Snel et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Global Imaging of Mitochondrial Morphology in Tissues Using Transgenic Mice Expressing Mitochondrially Targeted Enhanced Green Fluorescent Protein

(2010) Hiroshi SHITARA et al.   EXPERIMENTAL ANIMALS

The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives

(2010) T. Garland et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

(2008) Vitali Matyash et al.   JOURNAL OF LIPID RESEARCH

RPLC-Ion-Trap-FTMS Method for Lipid Profiling of Plasma: Method Validation and Application to p53 Mutant Mouse Model

(2008) Chunxiu Hu et al.   JOURNAL OF PROTEOME RESEARCH