Is there a special relationship between complex I activity and nigral neuronal loss in Parkinson’s disease? A critical reappraisal

Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson’s disease

(2020) Phillippa J Carling et al.   PROGRESS IN NEUROBIOLOGY

Damage in Mitochondrial DNA Associated with Parkinson's Disease

(2020) Rebeca Martín-Jiménez et al.   DNA AND CELL BIOLOGY

The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease

(2020) Giacomo Monzio Compagnoni et al.   MOLECULAR NEUROBIOLOGY

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4 mice and Leigh syndrome patients: A stabilizing role for NDUFAF2

(2020) Merel J.W. Adjobo-Hermans et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

(2020) Hyeseung Lee et al.   NEURON

Twinkle-associated familial parkinsonism with Lewy pathology

(2020) David P. Breen et al.   NEUROLOGY

The PARK2 Mutation Associated with Parkinson’s Disease Enhances the Vulnerability of Peripheral Blood Lymphocytes to Paraquat

(2020) Fengyu Ming et al.   Biomed Research International

Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease

(2019) Sunil S Adav et al.   Molecular Brain

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

(2019) Peng Wang et al.   PLoS Genetics

Investigation of mitochondrial biogenesis defects in single substantia nigra neurons using post-mortem human tissues

(2019) Chun Chen et al.   NEUROBIOLOGY OF DISEASE

Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment

(2018) Xian-Si Zeng et al.   ASN Neuro

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

Non-motor Parkinson disease: new concepts and personalised management

(2018) Nataliya Titova et al.   MEDICAL JOURNAL OF AUSTRALIA

Revisiting the Paraquat-Induced Sporadic Parkinson’s Disease-Like Model

(2018) Sussy Bastías-Candia et al.   MOLECULAR NEUROBIOLOGY

Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease

(2018) L Holper et al.   NEUROPSYCHOPHARMACOLOGY

On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease

(2018) Nicolas Giguère et al.   Frontiers in Neurology

Mammalian Mitochondrial Complex I Structure and Disease-Causing Mutations

(2018) Karol Fiedorczuk et al.   TRENDS IN CELL BIOLOGY

POLG-related disorders and their neurological manifestations

(2018) Shamima Rahman et al.   Nature Reviews Neurology

Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons

(2017) Won-Seok Choi et al.   Scientific Reports

The MPTP Story

(2017) J. William Langston   Journal of Parkinsons Disease

Mutations in Complex I Assembly Factor TMEM126B Result in Muscle Weakness and Isolated Complex I Deficiency

(2016) Laura Sánchez-Caballero et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons

(2016) Anne Grünewald et al.   ANNALS OF NEUROLOGY

Mitochondrial complex I-linked disease

(2016) Richard J. Rodenburg   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure of bacterial respiratory complex I

(2016) John M. Berrisford et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure and function of mitochondrial complex I

(2016) Christophe Wirth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Unraveling the complexity of mitochondrial complex I assembly: A dynamic process

(2016) Laura Sánchez-Caballero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7

(2016) M. Di Nottia et al.   CLINICAL GENETICS

Mitochondrial disorders in children: toward development of small-molecule treatment strategies

(2016) W. J. Koopman et al.   EMBO Molecular Medicine

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial DNA homeostasis is essential for nigrostriatal integrity

(2016) Charalampos Tzoulis et al.   MITOCHONDRION

Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency

(2016) Ariana P. Gatt et al.   MOVEMENT DISORDERS

Accessory subunits are integral for assembly and function of human mitochondrial complex I

(2016) David A. Stroud et al.   NATURE

Juvenile onset Parkinsonism with “pure nigral” degeneration and POLG1 mutation

(2016) Shyamal H. Mehta et al.   PARKINSONISM & RELATED DISORDERS

Gaining mass: the structure of respiratory complex I—from bacterial towards mitochondrial versions

(2015) James A Letts et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Exome sequencing identifies complex I NDUFV2 mutations as a novel cause of Leigh syndrome

(2015) Jessie M. Cameron et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I

(2015) Luke E. Formosa et al.   HUMAN MOLECULAR GENETICS

Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease

(2015) Jeff M. Bronstein et al.   MOVEMENT DISORDERS

Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo

(2015) Hyung-Wook Kim et al.   NEUROBIOLOGY OF AGING

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Mitochondrial epigenetics: an overlooked layer of regulation?

(2015) Monique G.P. van der Wijst et al.   TRENDS IN GENETICS

Effect of resveratrol on mitochondrial function: Implications in parkin-associated familiar Parkinson's disease

(2014) Anna Ferretta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bioenergetic and proteolytic defects in fibroblasts from patients with sporadic Parkinson's disease

(2014) Giulia Ambrosi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Architecture of mammalian respiratory complex I

(2014) Kutti R. Vinothkumar et al.   NATURE

Tissue- and Cell-Specific Mitochondrial Defect in Parkin-Deficient Mice

(2014) Maria Damiano et al.   PLoS One

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy

(2014) Joe H. Pogson et al.   PLoS Genetics

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Does Uncoupling Protein 2 Expression Qualify as Marker of Disease Status in LRRK2-Associated Parkinson's Disease?

(2013) Anne Grünewald et al.   ANTIOXIDANTS & REDOX SIGNALING

Investigating the function of [2Fe–2S] cluster N1a, the off-pathway cluster in complex I, by manipulating its reduction potential

(2013) James A. Birrell et al.   BIOCHEMICAL JOURNAL

Accessory subunits of mitochondrial complex I

(2013) Katarzyna Kmita et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders

(2013) Eino J. H. Palin et al.   BRAIN

Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations

(2013) Charalampos Tzoulis et al.   BRAIN

Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson’s disease

(2013) Heather Mortiboys et al.   BRAIN

The Impact of Pathogenic Mitochondrial DNA Mutations on Substantia Nigra Neurons

(2013) A. Reeve et al.   JOURNAL OF NEUROSCIENCE

The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress

(2013) Julia S. Schlehe et al.   NEUROBIOLOGY OF DISEASE

EFNS/MDS-ES recommendations for the diagnosis of Parkinson's disease

(2012) A. Berardelli et al.   EUROPEAN JOURNAL OF NEUROLOGY

Axon degeneration in Parkinson's disease

(2012) Robert E. Burke et al.   EXPERIMENTAL NEUROLOGY

Complex I deficiency: clinical features, biochemistry and molecular genetics

(2012) Elisa Fassone et al.   JOURNAL OF MEDICAL GENETICS

Mitophagy and Parkinson's disease: Be eaten to stay healthy

(2012) Rosa L.A. de Vries et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants

(2012) Sven Vilain et al.   PLoS Genetics

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

(2011) Derek P. Narendra et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial NADH:ubiquinone oxidoreductase (complex I) in eukaryotes: A highly conserved subunit composition highlighted by mining of protein databases

(2011) Pierre Cardol   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson's disease

(2011) Consiglia Pacelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model

(2011) Won-Seok Choi et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial complex I deficiency of nuclear origin

(2011) Hélène Pagniez-Mammeri et al.   MOLECULAR GENETICS AND METABOLISM

Mitochondrial complex I deficiency of nuclear origin

(2011) Hélène Pagniez-Mammeri et al.   MOLECULAR GENETICS AND METABOLISM

Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains

(2011) Rajeswara Babu Mythri et al.   NEUROCHEMICAL RESEARCH

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Oxidative stress in skin fibroblasts cultures from patients with Parkinson's disease

(2010) Pilar del Hoyo et al.   BMC Neurology

A common pattern of brain MRI imaging in mitochondrial diseases with complex I deficiency

(2010) A. S. Lebre et al.   JOURNAL OF MEDICAL GENETICS

High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency

(2010) Sarah E Calvo et al.   NATURE GENETICS

Leigh Disease with Brainstem Involvement in Complex I Deficiency due to Assembly Factor NDUFAF2 Defect

(2010) M. Herzer et al.   NEUROPEDIATRICS

Genetic variation of the mitochondrial complex I subunit NDUFV2 and Parkinson’s disease

(2010) Kenya Nishioka et al.   PARKINSONISM & RELATED DISORDERS

Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome

(2010) A. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease

(2009) F. Distelmaier et al.   BRAIN

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)

(2009) L. Flinn et al.   BRAIN

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

(2009) Vanessa A. Morais et al.   EMBO Molecular Medicine

Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies

(2009) Ana Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Contiguous gene deletion of ELOVL7, ERCC8 and NDUFAF2 in a patient with a fatal multisystem disorder

(2009) R. J.R.J. Janssen et al.   HUMAN MOLECULAR GENETICS

Baculovirus complementation restores a novelNDUFAF2mutation causing complex I deficiency

(2009) Saskia J.G. Hoefs et al.   HUMAN MUTATION

Mitochondrial Pathology in Muscle of a Patient with a Novel Parkin Mutation

(2009) Hasmet A. Hanagasi et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Reduced NADH coenzyme Q dehydrogenase activity in platelets of Parkinson's disease, but not Parkinson plus patients, from an Indian population

(2009) Merina Varghese et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts

(2008) Heather Mortiboys et al.   ANNALS OF NEUROLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

The unique neuroradiology of complex I deficiency due to NDUFA12L defect

(2008) Flora Barghuti et al.   MOLECULAR GENETICS AND METABOLISM

Mitochondrial Respiratory Dysfunction in Familiar Parkinsonism Associated with PINK1 Mutation

(2008) Claudia Piccoli et al.   NEUROCHEMICAL RESEARCH

Alpha-synuclein pathology and Parkinsonism associated withPOLG1mutations and multiple mitochondrial DNA deletions

(2008)   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat

(2008) W.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

(2008) C. A. Gautier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA