Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson’s Disease Models

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

(2021) Katie J. Mylonas et al.   Science Translational Medicine

Astrocyte senescence promotes glutamate toxicity in cortical neurons

(2020) Chandani Limbad et al.   PLoS One

Astragaloside IV inhibits astrocyte senescence: implication in Parkinson’s disease

(2020) Mei-Ling Xia et al.   Journal of Neuroinflammation

Senescence as an Amyloid Cascade: The Amyloid Senescence Hypothesis

(2020) Chaska C. Walton et al.   Frontiers in Cellular Neuroscience

Astrocyte Senescence and Alzheimer’s Disease: A Review

(2020) Xiaojuan Han et al.   Frontiers in Aging Neuroscience

The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson’s Disease Models

(2020) Dinesh Kumar Verma et al.   eNeuro

Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production

(2020) Heejung Chun et al.   NATURE NEUROSCIENCE

Cell Senescence in Neuropathology: a Focus on Neurodegeneration and Tumours

(2020) Gabriela Carreno et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake

(2019) Etienne Cartier et al.   Frontiers in Cellular Neuroscience

Astrocyte senescence: Evidence and significance

(2019) Justin Cohen et al.   AGING CELL

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Emerging senolytic agents derived from natural products

(2019) Wen Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

(2019) Markus Riessland et al.   Cell Stem Cell

Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice

(2019) Rachael H. Earls et al.   Journal of Neuroinflammation

The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model

(2018) Saebom Lee et al.   HUMAN MOLECULAR GENETICS

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

LARGE, an intellectual disability-associated protein, regulates AMPA-type glutamate receptor trafficking and memory

(2018) Bo Am Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Consequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence

(2018) Emilie Lukášová et al.   Cells

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy

(2015) Carol A. Lazzara et al.   BRAIN RESEARCH

Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway

(2015) Qingling Li et al.   Oncotarget

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

(2014) Florence C. C. Tan et al.   BIOGERONTOLOGY

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

(2013) S. J. Chinta et al.   JOURNAL OF INTERNAL MEDICINE

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

NS21: Re-defined and modified supplement B27 for neuronal cultures

(2008) Yucui Chen et al.   JOURNAL OF NEUROSCIENCE METHODS