Potential Roles of Exercise-Induced Plasma Metabolites Linking Exercise to Health Benefits

Exercise‐induced α‐ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1‐dependent adrenal activation

(2020) Yexian Yuan et al.   EMBO JOURNAL

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

(2020) Nicolas J. Pillon et al.   Nature Communications

Molecular Choreography of Acute Exercise

(2020) Kévin Contrepois et al.   CELL

Bacteria-derived metabolite, methylglyoxal, modulates the longevity ofC. elegansthrough TORC2/SGK-1/DAF-16 signaling

(2020) Min-Gi Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle

(2020) Matías Monsalves-Alvarez et al.   Nutrients

β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer’s disease pathology

(2020) Daniel C. Shippy et al.   Journal of Neuroinflammation

A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism

(2019) Zhimin Ou et al.   Cell Reports

Longitudinal plasma metabolomics of aging and sex

(2019) Burcu F. Darst et al.   Aging-US

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

(2019) Shogo Sato et al.   Cell Metabolism

L-Lactate Promotes Adult Hippocampal Neurogenesis

(2019) Yaeli Lev-Vachnish et al.   Frontiers in Neuroscience

Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running

(2019) Simon Lønbro et al.   PLoS One

Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in Humans

(2019) Jan Stautemas et al.   Frontiers in Physiology

Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice

(2019) Qiyu Tian et al.   AGING CELL

BHBA treatment improves cognitive function by targeting pleiotropic mechanisms in transgenic mouse model of Alzheimer's disease

(2019) Yancheng Wu et al.   FASEB JOURNAL

Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice

(2019) Xueqin Wang et al.   Neurotherapeutics

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

(2018) Leandro Z. Agudelo et al.   Cell Metabolism

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

(2018) Kristin I. Stanford et al.   Cell Metabolism

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

(2018) Martin Whitham et al.   Cell Metabolism

α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway

(2018) Xingcai Cai et al.   FASEB JOURNAL

An 8-Week Ketogenic Low Carbohydrate, High Fat Diet Enhanced Exhaustive Exercise Capacity in Mice

(2018) Sihui Ma et al.   Nutrients

β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

(2018) Yukiko Kitase et al.   Cell Reports

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

(2018) Young-min Han et al.   MOLECULAR CELL

The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level

(2017) Wiley Barton et al.   GUT

β-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibition of renal fibroblast activation and fibrosis

(2017) Huijuan Wang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Metabolite Profiles of Healthy Aging Index Are Associated With Cardiovascular Disease in African Americans: The Health, Aging, and Body Composition Study

(2017) Ashish Yeri et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study

(2017) Marie Hennebelle et al.   PSYCHIATRY RESEARCH

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

(2017) Cecilie Morland et al.   Nature Communications

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

(2017) Patrick Smith et al.   eLife

Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism

(2017) Jin Zhang et al.   Bone Research

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP

(2017) Bodil Ingerslev et al.   Molecular Metabolism

Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines

(2017) S. Pourteymour et al.   Molecular Metabolism

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice

(2017) Poonamjot Deol et al.   Scientific Reports

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans

(2016) Maja Schlittler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

(2016) Mamta Rai et al.   Annual Review of Physiology

Effects and dose–response relationships of resistance training on physical performance in youth athletes: a systematic review and meta-analysis

(2016) Melanie Lesinski et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function

(2016) Hyo Youl Moon et al.   Cell Metabolism

Alpha-ketoglutarate promotes skeletal muscle hypertrophy and protein synthesis through Akt/mTOR signaling pathways

(2016) Xingcai Cai et al.   Scientific Reports

β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetes

(2016) Chang-Xiang Shi et al.   Scientific Reports

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

D-beta-hydroxybutyrate extends lifespan in C. elegans

(2016) Clare Edwards et al.   Aging-US

BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice

(2015) Tae Woo Jung et al.   DIABETOLOGIA

Free-radical scavenging by tryptophan and its metabolites through electron transfer based processes

(2015) Adriana Pérez-González et al.   JOURNAL OF MOLECULAR MODELING

A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder

(2015) C M Sellgren et al.   MOLECULAR PSYCHIATRY

Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation

(2015) Emma L. Wightman et al.   PHYSIOLOGY & BEHAVIOR

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Integrative Biology of Exercise

(2014) John A. Hawley et al.   CELL

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

(2014) A. Carriere et al.   DIABETES

Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness

(2014) Kim M. Huffman et al.   DIABETOLOGIA

Exercise and associated dietary extremes impact on gut microbial diversity

(2014) Siobhan F Clarke et al.   GUT

Comprehensive review on lactate metabolism in human health

(2014) M. Adeva-Andany et al.   MITOCHONDRION

Role of Endogenous ENaC and TRP Channels in the Myogenic Response of Rat Posterior Cerebral Arteries

(2014) Eok-Cheon Kim et al.   PLoS One

The Potential of HDAC Inhibitors as Cognitive Enhancers

(2013) Johannes Gräff et al.   Annual Review of Pharmacology and Toxicology

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

(2013) Maja S. Engelstoft et al.   Molecular Metabolism

Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue

(2012) A. Galmozzi et al.   DIABETES

Anti-osteopenic effect of alpha-ketoglutarate sodium salt in ovariectomized rats

(2012) Radoslaw Piotr Radzki et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Exercise as a new physiological stimulus for brown adipose tissue activity

(2012) R. De Matteis et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Metabolomics Approach for Analyzing the Effects of Exercise in Subjects with Type 1 Diabetes Mellitus

(2012) Laura Brugnara et al.   PLoS One

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

(2011) William R. Swindell   AGEING RESEARCH REVIEWS

Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells

(2011) Kang Yao et al.   AMINO ACIDS

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

Simultaneous quantitative determination of α-ketoglutaric acid and 5-hydroxymethylfurfural in human plasma by gas chromatography–mass spectrometry

(2010) Bernhard M. Wagner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Chronicin vitroketosis is neuroprotective but not anti-convulsant

(2010) Marina Samoilova et al.   JOURNAL OF NEUROCHEMISTRY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Metabolic Signatures of Exercise in Human Plasma

(2010) G. D. Lewis et al.   Science Translational Medicine

Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway

(2009) Seung Hun Cha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell-cell and intracellular lactate shuttles

(2009) George A. Brooks   JOURNAL OF PHYSIOLOGY-LONDON

Brain metabolism dictates the polarity of astrocyte control over arterioles

(2008) Grant R. J. Gordon et al.   NATURE

β-Aminoisobutyric Acid Prevents Diet-induced Obesity in Mice With Partial Leptin Deficiency

(2008) Karima Begriche et al.   Obesity