A systems-approach to NAD+ restoration

Nicotinamide riboside supplementation does not alter whole‐body or skeletal muscle metabolic responses to a single bout of endurance exercise

(2021) Ben Stocks et al.   JOURNAL OF PHYSIOLOGY-LONDON

Tripeptide IRW Upregulates NAMPT Protein Levels in Cells and Obese C57BL/6J Mice

(2021) Khushwant S. Bhullar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy

(2021) Todd Bosanac et al.   BRAIN

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

(2020) Michael J. Bertoldo et al.   Cell Reports

Resistance training increases muscle NAD+ and NADH concentrations as well as NAMPT protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals

(2020) Donald A. Lamb et al.   Aging-US

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

(2020) Carlijn M E Remie et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity

(2020) Collin D Heer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure

(2020) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

(2020) Zayda L. Piedra-Quintero et al.   Frontiers in Immunology

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

(2019) Alanna M. Cameron et al.   NATURE IMMUNOLOGY

NAD+ metabolism governs the proinflammatory senescence-associated secretome

(2019) Timothy Nacarelli et al.   NATURE CELL BIOLOGY

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

(2019) Claudia Chini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Boosting NAD+ with a small molecule that activates NAMPT

(2019) Stephen J. Gardell et al.   Nature Communications

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

(2019) Dietrich Conze et al.   Scientific Reports

Effects of nicotinamide riboside on endocrine pancreatic function and incretin hormones in obese, non-diabetic men

(2019) Ole L Dollerup et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Single‐Voxel 1 H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD + ) in humans at 7T using a 32‐channel volume coil

(2019) Puneet Bagga et al.   MAGNETIC RESONANCE IN MEDICINE

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

(2019) Yasir S. Elhassan et al.   Cell Reports

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men

(2019) Ole L. Dollerup et al.   JOURNAL OF PHYSIOLOGY-LONDON

Loss of NAMPT in aging retinal pigment epithelium reduces NAD+ availability and promotes cellular senescence

(2018) Ravirajsinh N. Jadeja et al.   Aging-US

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

(2018) Ole L Dollerup et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

(2018) Harshini Neelakantan et al.   BIOCHEMICAL PHARMACOLOGY

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD + Decline

(2018) Mariana G. Tarragó et al.   Cell Metabolism

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

(2018) Ling Liu et al.   Cell Metabolism

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

NNMT activation can contribute to the development of fatty liver disease by modulating the NAD+ metabolism

(2018) Motoaki Komatsu et al.   Scientific Reports

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson’s Disease

(2018) David C. Schöndorf et al.   Cell Reports

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions

(2018) Stephanie A. Amici et al.   Frontiers in Immunology

The Plasma NAD+ Metabolome is Dysregulated in ‘normal’ Ageing

(2018) James Clement et al.   REJUVENATION RESEARCH

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

(2017) Karim Gariani et al.   JOURNAL OF HEPATOLOGY

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

(2017) Partha Mukhopadhyay et al.   JOURNAL OF HEPATOLOGY

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NAD and the aging process: Role in life, death and everything in between

(2017) Claudia C.S. Chini et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

NAD + in Aging: Molecular Mechanisms and Translational Implications

(2017) Evandro F. Fang et al.   TRENDS IN MOLECULAR MEDICINE

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders

(2017) Natalia Salvadores et al.   Frontiers in Neuroscience

(−)-P7C3-S243 Protects a Rat Model of Alzheimer’s Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia

(2017) Jaymie R. Voorhees et al.   BIOLOGICAL PSYCHIATRY

Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1

(2017) Cao Ma et al.   PLoS One

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

(2017) Sophia E. Airhart et al.   PLoS One

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

(2016) Simin N. Meydani et al.   Aging-US

Hepatic NAD+deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing

(2016) Can-Can Zhou et al.   BRITISH JOURNAL OF PHARMACOLOGY

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

(2016) David W. Frederick et al.   Cell Metabolism

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

(2016) Juliana Camacho-Pereira et al.   Cell Metabolism

Normalization of NAD+Redox Balance as a Therapy for Heart FailureClinical Perspective

(2016) Chi Fung Lee et al.   CIRCULATION

Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke

(2016) Shu-Na Wang et al.   CNS Neuroscience & Therapeutics

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

(2016) Sarmistha Mukherjee et al.   HEPATOLOGY

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

(2016) Joanna Ratajczak et al.   Nature Communications

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

NAMPT-Mediated NAD + Biosynthesis Is Essential for Vision In Mice

(2016) Jonathan B. Lin et al.   Cell Reports

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

(2015) Xiao-Hong Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

(2014) Eija Pirinen et al.   Cell Metabolism

A High-Fat Diet and NAD + Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome

(2014) Morten Scheibye-Knudsen et al.   Cell Metabolism

Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

(2014) Kevin D. Brown et al.   Cell Metabolism

Increasing NAD Synthesis in Muscle via Nicotinamide Phosphoribosyltransferase Is Not Sufficient to Promote Oxidative Metabolism

(2014) David W. Frederick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

(2014) Daniel Kraus et al.   NATURE

50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

(2014) Eric Verdin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Elevated microRNA-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT

(2013) Sung-E Choi et al.   AGING CELL

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Nicotinamide Phosphoribosyltransferase Is Required for the Calorie Restriction-Mediated Improvements in Oxidative Stress, Mitochondrial Biogenesis, and Metabolic Adaptation

(2013) J. Song et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The caloric restriction paradigm: Implications for healthy human aging

(2012) Rozalyn M. Anderson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

(2012) Péter Bai et al.   Cell Metabolism

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

Reprogramming cellular events by poly(ADP-ribose)-binding proteins

(2012) Jana Krietsch et al.   MOLECULAR ASPECTS OF MEDICINE

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

Nicotinamide Phosphoribosyltransferase May Be Involved in Age-Related Brain Diseases

(2012) Li-Ying Liu et al.   PLoS One

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis

(2012) R. Tesla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flavonoids as inhibitors of human CD38

(2011) Esther Kellenberger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

(2011) Péter Bai et al.   Cell Metabolism

Population variability in CD38 activity: Correlation with age and significant effect of TNF-α -308G>A and CD38 184C>G SNPs

(2011) Valeria Polzonetti et al.   MOLECULAR GENETICS AND METABOLISM

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

(2011) C. Boehler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of NAD interacting residues in proteins

(2010) Hifzur R Ansari et al.   BMC BIOINFORMATICS

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

Inhibition of Nicotinamide Phosphoribosyltransferase

(2010) Maria Pittelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment

(2009) Nica M. Borradaile et al.   AGING CELL

Skeletal muscle NAMPT is induced by exercise in humans

(2009) Sheila R. Costford et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

(2009) Erika Koltai et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Tissue-specific regulation of SIRT1 by calorie restriction

(2008) D. Chen et al.   GENES & DEVELOPMENT

Retinol-binding Protein 4 and Nicotinamide Phosphoribosyltransferase/Visfatin in Rat Obesity Models

(2008) J. Mercader et al.   HORMONE AND METABOLIC RESEARCH

Life Span Extension and Neuronal Cell Protection byDrosophilaNicotinamidase

(2008) Vitaly Balan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology

(2008) Fabio Malavasi et al.   PHYSIOLOGICAL REVIEWS