Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms

Regulation of immune-driven pathogenesis in Parkinson’s disease by gut microbiota

(2020) Wenxia Zheng et al.   BRAIN BEHAVIOR AND IMMUNITY

Autophagy in Parkinson's Disease

(2020) Xu Hou et al.   JOURNAL OF MOLECULAR BIOLOGY

Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson's Disease

(2020) Tengzhu Ren et al.   Frontiers in Neurology

Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases

(2020) Olga Corti et al.   JOURNAL OF NEUROCHEMISTRY

Microbiota Composition and Metabolism Are Associated With Gut Function in Parkinson's Disease

(2020) Mihai S. Cirstea et al.   MOVEMENT DISORDERS

Gut microbiota differences between healthy older adults and individuals with Parkinson’s disease: A systematic review

(2020) Nathan D. Nuzum et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Long-Term Coffee Consumption is Associated with Fecal Microbial Composition in Humans

(2020) Sonia González et al.   Nutrients

Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson’s Disease in the Harvard Biomarkers Study

(2020) Rachit Bakshi et al.   Journal of Parkinsons Disease

Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease

(2020) Giulia Lamonaca et al.   Cells

Can Gut Microbiota Be a Good Predictor for Parkinson’s Disease? A Machine Learning Approach

(2020) Daniele Pietrucci et al.   Brain Sciences

Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease

(2020) Yu-Lin Guo et al.   ACTA PHARMACOLOGICA SINICA

Gut Microbiota Dynamics in Parkinsonian Mice

(2020) Emily Klann et al.   ACS Chemical Neuroscience

Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease

(2020) Yue Qin et al.   BRAIN BEHAVIOR AND IMMUNITY

α-Synuclein Overexpression Induces Lysosomal Dysfunction and Autophagy Impairment in Human Neuroblastoma SH-SY5Y

(2020) Ana Carolina Nascimento et al.   NEUROCHEMICAL RESEARCH

Association of caffeine and related analytes with resistance to Parkinson’s disease among LRRK2 mutation carriers: A metabolomic study

(2020) Grace F Crotty et al.   NEUROLOGY

Microbiome, Parkinson’s Disease and Molecular Mimicry

(2019) Fabiana Miraglia et al.   Cells

Inhibition of thymocyte autophagy-associated CD4+T thymopoiesis is involved in asthma susceptibility in mice exposed to caffeine prenatally

(2019) Han-xiao Liu et al.   ARCHIVES OF TOXICOLOGY

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism

(2019) Vayu Maini Rekdal et al.   SCIENCE

The gut microbiota: A novel therapeutic target in Parkinson's disease?

(2019) Michal Lubomski et al.   PARKINSONISM & RELATED DISORDERS

The Therapeutic Implications of Tea Polyphenols Against Dopamine (DA) Neuron Degeneration in Parkinson’s Disease (PD)

(2019) Zhou et al.   Cells

Caffeine Consumption and the Colonic Mucosa-Associated Gut Microbiota

(2019) Shawn Gurwara et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Autophagy lysosomal pathway dysfunction in Parkinson's disease; evidence from human genetics

(2019) Konstantin Senkevich et al.   PARKINSONISM & RELATED DISORDERS

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains

(2019) Badshah et al.   Biomolecules

Alterations of the gut microbiota with antibiotics protects dopamine neuron loss and improve motor deficits in a pharmacological rodent model of Parkinson's disease

(2019) Dimitri N. Koutzoumis et al.   EXPERIMENTAL NEUROLOGY

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

(2018) Carolina Pellegrini et al.   ACTA NEUROPATHOLOGICA

The Corticostriatal Adenosine A 2A Receptor Controls Maintenance and Retrieval of Spatial Working Memory

(2018) Zhihui Li et al.   BIOLOGICAL PSYCHIATRY

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson’s disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway

(2018) Meng-Fei Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease

(2018) Yiwei Qian et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of Autophagy in Parkinson’s Disease

(2018) Silvia Cerri et al.   CURRENT MEDICINAL CHEMISTRY

Association of coffee consumption and non-motor symptoms in drug-naïve, early-stage Parkinson's disease

(2018) Bang-Hoon Cho et al.   PARKINSONISM & RELATED DISORDERS

Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases

(2018) Sara Gerhardt et al.   Nutrients

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2018) Emilie Faivre et al.   Frontiers in Molecular Neuroscience

Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum

(2018) Yanan Luan et al.   Frontiers in Neuroscience

Coffee Intake in Midlife and Risk of Dementia and its Neuropathologic Correlates

(2018) Rebecca P. Gelber et al.   JOURNAL OF ALZHEIMERS DISEASE

Alterations in the Gut Microbiota of Rats Chronically Exposed to Volatilized Cocaine and Its Active Adulterants Caffeine and Phenacetin

(2018) Cecilia Scorza et al.   NEUROTOXICITY RESEARCH

Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome

(2018) Kazuchika Nishitsuji et al.   Scientific Reports

Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity

(2018) Lap Ho et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB

(2018) Run Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caffeine attenuates brain injury but increases mortality induced by high-intensity blast wave exposure

(2018) Ya-Lei Ning et al.   TOXICOLOGY LETTERS

Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children

(2017) Daniele Wikoff et al.   FOOD AND CHEMICAL TOXICOLOGY

Autophagy mediated by endoplasmic reticulum stress enhances the caffeine-induced apoptosis of hepatic stellate cells

(2017) Yongjian Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Acute high-caffeine exposure increases autophagic flux and reduces protein synthesis in C2C12 skeletal myotubes

(2017) M. A. Hughes et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Cognitive impairment in Parkinson's disease

(2017) Nour Majbour et al.   LANCET NEUROLOGY

Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases

(2017) Maria H. Madeira et al.   MEDIATORS OF INFLAMMATION

Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease

(2017) Tim E. Moors et al.   Molecular Neurodegeneration

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

(2017) Diana G Ferreira et al.   NATURE NEUROSCIENCE

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

Caffeine as symptomatic treatment for Parkinson disease (Café-PD)

(2017) Ronald B. Postuma et al.   NEUROLOGY

The Parkinson’s disease-associated GPR37 receptor interacts with striatal adenosine A2A receptor controlling its cell surface expression and function in vivo

(2017) Xavier Morató et al.   Scientific Reports

Caffeine Suppresses Amyloid-β Levels in Plasma and Brain of Alzheimer's Disease Transgenic Mice

(2017) Chuanhai Cao et al.   JOURNAL OF ALZHEIMERS DISEASE

Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study

(2017) Marjo H. Eskelinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic Caffeine Consumption Prevents Memory Disturbance in Different Animal Models of Memory Decline

(2017) Rodrigo A. Cunha et al.   JOURNAL OF ALZHEIMERS DISEASE

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinsons Disease

(2016) Pilar Rivero-Ríos et al.   Current Neuropharmacology

Aberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy

(2016) Qidi Hu et al.   EXPERIMENTAL NEUROLOGY

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies

(2016) Maria Xilouri et al.   MOVEMENT DISORDERS

Advances in markers of prodromal Parkinson disease

(2016) Ronald B. Postuma et al.   Nature Reviews Neurology

An evaluation of istradefylline treatment on Parkinsonian motor and cognitive deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated macaque models

(2016) Wai Kin D. Ko et al.   NEUROPHARMACOLOGY

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

α-Synuclein and Lewy pathology in Parkinsonʼs disease

(2015) Lorraine V. Kalia et al.   CURRENT OPINION IN NEUROLOGY

Influence of caffeine on 3,4-methylenedioxymethamphetamine-induced dopaminergic neuron degeneration and neuroinflammation is age-dependent

(2015) Lucia Frau et al.   JOURNAL OF NEUROCHEMISTRY

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

(2015) Lisa Klingelhoefer et al.   Nature Reviews Neurology

Inactivation of adenosine A 2A receptors reverses working memory deficits at early stages of Huntington's disease models

(2015) Wei Li et al.   NEUROBIOLOGY OF DISEASE

Optogenetic Activation of Adenosine A2A Receptor Signaling in the Dorsomedial Striatopallidal Neurons Suppresses Goal-Directed Behavior

(2015) Yan Li et al.   NEUROPSYCHOPHARMACOLOGY

Autophagy Inhibition by Caffeine Increases Toxicity of Methamphetamine in SH-SY5Y Neuroblastoma Cell Line

(2015) Rujiraporn Pitaksalee et al.   NEUROTOXICITY RESEARCH

Gut microbiota mediate caffeine detoxification in the primary insect pest of coffee

(2015) Javier A. Ceja-Navarro et al.   Nature Communications

Differential effect of caffeine intake in subjects with genetic susceptibility to Parkinson’s Disease

(2015) Prakash M. Kumar et al.   Scientific Reports

Linking Smoking, Coffee, Urate, and Parkinson’s Disease – A Role for Gut Microbiota?

(2015) Filip Scheperjans et al.   Journal of Parkinsons Disease

Caffeine induces macroautophagy and confers a cytocidal effect on food spoilage yeast in combination with benzoic acid

(2014) Gal Winter et al.   Autophagy

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

(2014) Anne-Maria Poehler et al.   Autophagy

Caffeine promotes autophagy in skeletal muscle cells by increasing the calcium-dependent activation of AMP-activated protein kinase

(2014) T.S. Mathew et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caffeine prevents human prion protein-mediated neurotoxicity through the induction of autophagy

(2014) JI-HONG MOON et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Brain Injection of  -Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker

(2014) A. N. Sacino et al.   JOURNAL OF NEUROSCIENCE

Chronic coffee consumption in the diet-induced obese rat: impact on gut microbiota and serum metabolomics

(2014) Theresa E. Cowan et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Gut feelings about smoking and coffee in Parkinson's disease

(2014) Pascal Derkinderen et al.   MOVEMENT DISORDERS

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology

(2014) Cyril Laurent et al.   NEUROBIOLOGY OF AGING

Caffeine Interaction with Glutamate Receptor Gene GRIN2A: Parkinson's Disease in Swedish Population

(2014) Naomi Yamada-Fowler et al.   PLoS One

Regulation of Fear Responses by Striatal and Extrastriatal Adenosine A2A Receptors in Forebrain

(2013) Catherine J. Wei et al.   BIOLOGICAL PSYCHIATRY

Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2Areceptors in the control of dopamine release in the rat striatum

(2013) P Garção et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dietary and lifestyle variables in relation to incidence of Parkinson’s disease in Greece

(2013) Andreas Kyrozis et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Beverage caffeine intakes in the U.S.

(2013) Diane C. Mitchell et al.   FOOD AND CHEMICAL TOXICOLOGY

Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease

(2013) Hui Qi et al.   Geriatrics & Gerontology International

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

(2013) Rohit A. Sinha et al.   HEPATOLOGY

Adenosine A2A Receptor Deficiency Alleviates Blast-Induced Cognitive Dysfunction

(2013) Ya-Lei Ning et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Caffeine consumption and risk of dyskinesia in CALM-PD

(2013) Anne-Marie A. Wills et al.   MOVEMENT DISORDERS

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Caffeine is a potent stimulator of autophagy to reduce hepatic lipid content—a coffee for NAFLD?

(2013) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

The gut microbiota — masters of host development and physiology

(2013) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Protein degradation pathways in Parkinson’s disease: curse or blessing

(2012) Darius Ebrahimi-Fakhari et al.   ACTA NEUROPATHOLOGICA

Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease

(2012) Patricia K. Sonsalla et al.   EXPERIMENTAL NEUROLOGY

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

α-Synuclein and Neuronal Cell Death

(2012) Toru Yasuda et al.   MOLECULAR NEUROBIOLOGY

Caffeine and risk of Parkinson's disease in a large cohort of men and women

(2012) Natalia Palacios et al.   MOVEMENT DISORDERS

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

An exploratory analysis on gene-environment interactions for Parkinson disease

(2012) Jianjun Gao et al.   NEUROBIOLOGY OF AGING

Caffeine for treatment of Parkinson disease: A randomized controlled trial

(2012) R. B. Postuma et al.   NEUROLOGY

Distribution and accumulation of caffeine in rat tissues and its inhibition on semicarbazide-sensitive amine oxidase

(2012) Baoquan Che et al.   NEUROTOXICOLOGY

Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease

(2011) Anil Kachroo et al.   ANNALS OF NEUROLOGY

The Parkinson disease protein α-synuclein inhibits autophagy

(2011) Ashley R. Winslow et al.   Autophagy

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson’s disease

(2011) R. A. Popat et al.   EUROPEAN JOURNAL OF NEUROLOGY

Preladenant in patients with Parkinson's disease and motor fluctuations: a phase 2, double-blind, randomised trial

(2011) Robert A Hauser et al.   LANCET NEUROLOGY

Selective inactivation of adenosine A2A receptors in striatal neurons enhances working memory and reversal learning

(2011) C. J. Wei et al.   LEARNING & MEMORY

Anti-inflammatory properties of intestinal Bifidobacterium strains isolated from healthy infants

(2011) Ekaterina V. Khokhlova et al.   MICROBIOLOGY AND IMMUNOLOGY

Caffeine in Parkinson's disease: A pilot open-label, dose-escalation study

(2011) Robert D. Altman et al.   MOVEMENT DISORDERS

Caffeine potentiates methamphetamine-induced toxicity both in vitro and in vivo

(2011) Theerin Sinchai et al.   NEUROSCIENCE LETTERS

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Genome-Wide Gene-Environment Study Identifies Glutamate Receptor Gene GRIN2A as a Parkinson's Disease Modifier Gene via Interaction with Coffee

(2011) Taye H. Hamza et al.   PLoS Genetics

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease

(2010) Angie A Kehagia et al.   LANCET NEUROLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Mild cognitive impairment in Parkinson disease: A multicenter pooled analysis

(2010) D. Aarsland et al.   NEUROLOGY

Caffeine attenuates lipopolysaccharide-induced neuroinflammation

(2010) Holly M. Brothers et al.   NEUROSCIENCE LETTERS

Alpha-Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection

(2010) He-Jin Lee et al.   Oxidative Medicine and Cellular Longevity

Preferential enhancement of working memory in mice lacking adenosine A2A receptors

(2009) Sai-jun Zhou et al.   BRAIN RESEARCH

Adenosine signaling and function in glial cells

(2009) D Boison et al.   CELL DEATH AND DIFFERENTIATION

Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by  -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

(2009) P. M. Canas et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Adenosine, adenosine A2A antagonists, and Parkinson's disease

(2009) P. Jenner et al.   PARKINSONISM & RELATED DISORDERS

Nucleus Accumbens Adenosine A2A Receptors Regulate Exertion of Effort by Acting on the Ventral Striatopallidal Pathway

(2008) S. Mingote et al.   JOURNAL OF NEUROSCIENCE

Novel therapeutic strategies for multiple sclerosis — a multifaceted adversary

(2008) Rocio S. Lopez-Diego et al.   NATURE REVIEWS DRUG DISCOVERY

Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk

(2007) Karen M. Powers et al.   MOVEMENT DISORDERS