Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

The Membrane Interactions of Synuclein: Physiology and Pathology

(2021) Gautam Runwal et al.   Annual Review of Pathology-Mechanisms of Disease

A Novel SNCA A30G Mutation Causes Familial Parkinsonʼs Disease

(2021) Hui Liu et al.   MOVEMENT DISORDERS

Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease

(2021) Eleanor Sinclair et al.   Nature Communications

Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain

(2021) Nelson Ferreira et al.   Acta Neuropathologica Communications

Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential

(2021) Nelson Ferreira et al.   ACTA NEUROPATHOLOGICA

Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction

(2021) Maria Ericsson et al.   BRAIN RESEARCH

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy

(2021) Tim E. Moors et al.   ACTA NEUROPATHOLOGICA

Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

(2021) Haejin Yoon et al.   MOLECULAR CELL

Wild-type GBA1 increases the α-synuclein tetramer–monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

(2021) Kelly E. Glajch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures

(2021) Justin W. Nicholatos et al.   eNeuro

Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson’s disease

(2021) Victor Girard et al.   PLoS Genetics

iPSC modeling of young-onset Parkinson’s disease reveals a molecular signature of disease and novel therapeutic candidates

(2020) A. H. Laperle et al.   NATURE MEDICINE

Vesicle trafficking and lipid metabolism in synucleinopathy

(2020) Saranna Fanning et al.   ACTA NEUROPATHOLOGICA

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor

(2020) Elizabeth Terry-Kantor et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α ‐Synuclein Mice

(2020) Silke Nuber et al.   ANNALS OF NEUROLOGY

Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance

(2020) Oeystein Roed Brekk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

(2020) Patricia Rada et al.   Cell Death & Disease

Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy

(2020) Souvarish Sarkar et al.   npj Parkinsons Disease

Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats

(2019) Nathalie Van Den Berge et al.   ACTA NEUROPATHOLOGICA

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase

(2019) Thibaut Imberdis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity

(2019) Martin Soste et al.   Cell Systems

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

(2019) Maria Lytrivi et al.   JOURNAL OF MOLECULAR BIOLOGY

A Perspective: Active Role of Lipids in Neurotransmitter Dynamics

(2019) Pekka A. Postila et al.   MOLECULAR NEUROBIOLOGY

Somatic copy number gains of α-synuclein (SNCA) in Parkinson’s disease and multiple system atrophy brains

(2018) Katya Mokretar et al.   BRAIN

α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

(2018) Dalila G. Ordonez et al.   NEURON

Augmented frontal cortex diacylglycerol levels in Parkinson’s disease and Lewy Body Disease

(2018) Paul L. Wood et al.   PLoS One

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

(2018) Sangjune Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promising Metabolite Profiles in the Plasma and CSF of Early Clinical Parkinson's Disease

(2018) Daniel Stoessel et al.   Frontiers in Aging Neuroscience

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

(2018) Saranna Fanning et al.   MOLECULAR CELL

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease

(2018) Silke Nuber et al.   NEURON

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity

(2018) Benjamin M. Vincent et al.   Cell Reports

Association of GALC, ZNF184, IL1R2 and ELOVL7 With Parkinson’s Disease in Southern Chinese

(2018) Gen Li et al.   Frontiers in Aging Neuroscience

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

(2017) Ulf Dettmer et al.   HUMAN MOLECULAR GENETICS

Activation of  -Glucocerebrosidase Reduces Pathological  -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons

(2016) J. R. Mazzulli et al.   JOURNAL OF NEUROSCIENCE

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity

(2014) Madeleen Bosma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?

(2014) Rohit B. Sharma et al.   Current Diabetes Reports

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson’s disease in a Chinese population

(2013) Yong Ping Chen et al.   JOURNAL OF CLINICAL NEUROSCIENCE

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study

(2013) Michelle M. Mielke et al.   PLoS One

Lipid Metabolism and Toxicity in the Heart

(2012) Ira J. Goldberg et al.   Cell Metabolism

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Genome-wide association study confirms extant PD risk loci among the Dutch

(2011) Javier Simón-Sánchez et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex

(2011) Danni Cheng et al.   PLoS One

Alpha-synuclein, lipids and Parkinson’s disease

(2010) Violeta Ruipérez et al.   PROGRESS IN LIPID RESEARCH

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   BIOCHEMISTRY

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of α-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response

(2009) Mikhail Y. Golovko et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: A biological link between Gaucher disease and parkinsonism

(2009) Amy B. Manning-Boğ et al.   NEUROTOXICOLOGY

N-terminal region of α-synuclein is essential for the fatty acid-induced oligomerization of the molecules

(2008) Hiroki Karube et al.   FEBS LETTERS

Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain

(2007) Julia Fuchs et al.   FASEB JOURNAL

α-Synuclein Selectively Binds to Anionic Phospholipids Embedded in Liquid-Disordered Domains

(2007) Martin Stöckl et al.   JOURNAL OF MOLECULAR BIOLOGY

Brain prostaglandin formation is increased by α-synuclein gene-ablation during global ischemia

(2007) Mikhail Y. Golovko et al.   NEUROSCIENCE LETTERS