Exercise-Induced Lactate Release Mediates Mitochondrial Biogenesis in the Hippocampus of Mice via Monocarboxylate Transporters

Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System

(2021) Jingyun Hu et al.   Frontiers in Physiology

High-intensity Intermittent Training Enhances Spatial Memory and Hippocampal Neurogenesis Associated with BDNF Signaling in Rats

(2021) Masahiro Okamoto et al.   CEREBRAL CORTEX

Olive leaf extract prevents obesity, cognitive decline, and depression and improves exercise capacity in mice

(2021) Toshio Mikami et al.   Scientific Reports

Lactate as a fulcrum of metabolism

(2020) George A. Brooks   Redox Biology

Oral Lactate Administration Additively Enhances Endurance Training-Induced Increase in Cytochrome C Oxidase Activity in Mouse Soleus Muscle

(2020) Kenya Takahashi et al.   Nutrients

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

(2019) Lauretta El Hayek et al.   JOURNAL OF NEUROSCIENCE

L-Lactate Promotes Adult Hippocampal Neurogenesis

(2019) Yaeli Lev-Vachnish et al.   Frontiers in Neuroscience

PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training

(2019) Jens Frey Halling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Involvement of l-lactate in hippocampal dysfunction of type I diabetes

(2019) Riho Kobayashi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Intermittent intense exercise protects against cognitive decline in a similar manner to moderate exercise in chronically stressed mice

(2018) Hyunjin Lee et al.   BEHAVIOURAL BRAIN RESEARCH

Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway

(2018) Mohammad Azimi et al.   PEPTIDES

High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats

(2018) Daniel A. Freitas et al.   PHYSIOLOGY & BEHAVIOR

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

(2018) Mychael V. Lourenco et al.   NATURE MEDICINE

Astrocytic glycogen-derived lactate fuels the brain during exhaustive exercise to maintain endurance capacity

(2017) Takashi Matsui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle

(2016) Yu Kitaoka et al.   Applied Physiology Nutrition and Metabolism

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Peripheral administration of lactate produces antidepressant-like effects

(2016) A Carrard et al.   MOLECULAR PSYCHIATRY

Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval

(2016) Rie Ishikawa et al.   eLife

Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver

(2015) Ilona Zawada et al.   Aging-US

Rapidly elevated levels of PGC-1α-b protein in human skeletal muscle after exercise: exploring regulatory factors in a randomized controlled trial

(2015) Eva-karin Gidlund et al.   JOURNAL OF APPLIED PHYSIOLOGY

High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise

(2015) Cinthia Maria Saucedo Marquez et al.   JOURNAL OF APPLIED PHYSIOLOGY

Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins

(2014) Masaki Takimoto et al.   JOURNAL OF APPLIED PHYSIOLOGY

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Lactate administration reproduces specific brain and liver exercise-related changes

(2013) Lezi E et al.   JOURNAL OF NEUROCHEMISTRY

Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle

(2013) Ayesha Saleem et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial dysfunction in the hippocampus of rats caused by chronic oxidative stress

(2013) E. Rodríguez-Martínez et al.   NEUROSCIENCE

Disconnecting Mitochondrial Content from Respiratory Chain Capacity in PGC-1-Deficient Skeletal Muscle

(2013) Glenn C. Rowe et al.   Cell Reports

Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2

(2013) Elizabeth D Kirby et al.   eLife

Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain

(2012) Morten Overgaard et al.   FASEB JOURNAL

Exercise induces mitochondrial biogenesis after brain ischemia in rats

(2012) Q. Zhang et al.   NEUROSCIENCE

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Exercise training increases mitochondrial biogenesis in the brain

(2011) Jennifer L. Steiner et al.   JOURNAL OF APPLIED PHYSIOLOGY

Exercise Increases Mitochondrial PGC-1α Content and Promotes Nuclear-Mitochondrial Cross-talk to Coordinate Mitochondrial Biogenesis

(2011) Adeel Safdar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β2-adrenergic receptor activation

(2010) Miki Tadaishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acute endurance exercise increases the nuclear abundance of PGC-1α in trained human skeletal muscle

(2010) Jonathan P. Little et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

PGC-1α and PGC-1β Regulate Mitochondrial Density in Neurons

(2009) Przemyslaw Wareski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood Lactate is an Important Energy Source for the Human Brain

(2009) Gerrit van Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NMDA Receptor Dependent PGC-1α Up-Regulation Protects the Cortical Neuron Against Oxygen-Glucose Deprivation/Reperfusion Injury

(2009) Yun Luo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Exercise and adrenaline increase PGC-1α mRNA expression in rat adipose tissue

(2009) Lindsey N. Sutherland et al.   JOURNAL OF PHYSIOLOGY-LONDON

miRNA in the Regulation of Skeletal Muscle Adaptation to Acute Endurance Exercise in C57Bl/6J Male Mice

(2009) Adeel Safdar et al.   PLoS One

Acute exercise induces biphasic increase in respiratory mRNA in skeletal muscle

(2008) Shin-ichi Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lactate fuels the human brain during exercise

(2008) Bjørn Quistorff et al.   FASEB JOURNAL