4.6 Review

BDNF mediates adaptive brain and body responses to energetic challenges

Journal

TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 25, Issue 2, Pages 89-98

Publisher

CELL PRESS
DOI: 10.1016/j.tem.2013.10.006

Keywords

Alzheimer's disease; BDNF; diabetes; exercise; glucocorticoid; insulin resistance; learning and memory; obesity

Funding

  1. National Institute on Aging

Ask authors/readers for more resources

Emerging findings suggest that brain-derived neurotrophic factor (BDNF) serves widespread roles in regulating energy homeostasis by controlling patterns of feeding and physical activity, and by modulating glucose metabolism in peripheral tissues. BDNF mediates the beneficial effects of energetic challenges such as vigorous exercise and fasting on cognition, mood, cardiovascular function, and on peripheral metabolism. By stimulating glucose transport and mitochondria! biogenesis BDNF bolsters cellular bioenergetics and protects neurons against injury and disease. By acting in the brain and periphery, BDNF increases insulin sensitivity and parasympathetic tone. Genetic factors, a 'couch potato' lifestyle, and chronic stress impair BDNF signaling, and this may contribute to the pathogenesis of metabolic syndrome. Novel BDNF-focused interventions are being developed for obesity, diabetes, and neurological disorders.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available