ROS-Induced mtDNA Release: The Emerging Messenger for Communication between Neurons and Innate Immune Cells during Neurodegenerative Disorder Progression

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS

(2021) Xinxin Zuo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hydrogen sulfide is neuroprotective in Alzheimer’s disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

(2021) Daniel Giovinazzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 suppresses innate immune signaling to promote tumorigenesis

(2021) Monisankar Ghosh et al.   CANCER CELL

Monoamineoxidase-B (MAO-B) Inhibitors in theTreatment of Alzheimer’s and Parkinson’s Disease

(2021) Zeynep Özdemir et al.   CURRENT MEDICINAL CHEMISTRY

Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment

(2021) Haruki Koike et al.   MOLECULES

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases

(2021) Tianbai Li et al.   Frontiers in Aging Neuroscience

Airway Epithelial cGAS Is Critical for Induction of Experimental Allergic Airway Inflammation

(2020) Yinling Han et al.   JOURNAL OF IMMUNOLOGY

Phase 2 randomized placebo controlled double blind study to assess the efficacy and safety of tecfidera in patients with amyotrophic lateral sclerosis (TEALS Study)

(2020) Steve Vucic et al.   MEDICINE

Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer’s disease

(2020) Tanusree Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

Mitochondrial DNA from hepatocytes induces upregulation of interleukin-33 expression of macrophages in nonalcoholic steatohepatitis

(2020) Yinjie Gao et al.   DIGESTIVE AND LIVER DISEASE

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

(2020) Long Shuang Huang et al.   IMMUNITY

CRISPR/Cas9-Mediated Gene Correction to Understand ALS

(2020) Yeomin Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ten Unsolved Questions About Neuroinflammation in Parkinson's Disease

(2020) Etienne C. Hirsch et al.   MOVEMENT DISORDERS

TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways

(2020) Xianyi Meng et al.   Oxidative Medicine and Cellular Longevity

Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis

(2020) Li Zhong et al.   Cell Discovery

Exploring molecular approaches in Amyotrophic lateral sclerosis: Drug targets from clinical and pre-clinical findings

(2020) Mamtaj Alam et al.   Current Molecular Pharmacology

Antioxidant and Anti-inflammatory Effect of Nrf2 Inducer Dimethyl Fumarate in Neurodegenerative Diseases

(2020) Sarah A. Scuderi et al.   Antioxidants

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

(2020) Chien-Hsiung Yu et al.   CELL

The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response

(2020) Shinrye Lee et al.   Journal of Neuroinflammation

Mitochondrial damage-associated molecular patterns stimulate reactive oxygen species production in human microglia

(2020) Milena Nasi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Glycosphingolipids and neuroinflammation in Parkinson’s disease

(2020) Karim Belarbi et al.   Molecular Neurodegeneration

Efficacy of Sulforaphane in Neurodegenerative Diseases

(2020) Giovanni Schepici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion

(2020) Xufei Zhang et al.   Cell Death & Disease

Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles

(2020) An Ning Cheng et al.   Journal for ImmunoTherapy of Cancer

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

Mitochondrial dysfunction in the development and progression of neurodegenerative diseases

(2020) Joseph Johnson et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

(2019) Archana Prasad et al.   Frontiers in Molecular Neuroscience

Mitochondrial fission-induced mtDNA stress promotes tumor-associated macrophage infiltration and HCC progression

(2019) Dengke Bao et al.   ONCOGENE

The benefits of neuroinflammation for the repair of the injured central nervous system

(2019) Heather Y. F. Yong et al.   Cellular & Molecular Immunology

Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

(2019) Amanda Cano et al.   JOURNAL OF CONTROLLED RELEASE

Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

(2019) Lauren D. Aarreberg et al.   MOLECULAR CELL

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

(2019) Pamela Maher   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

ccf-mtDNA as a Potential Link Between the Brain and Immune System in Neuro-Immunological Disorders

(2019) Stefano Gambardella et al.   Frontiers in Immunology

Epigallocatechin‐3‐Gallate Attenuates Microglial Inflammation and Neurotoxicity by Suppressing the Activation of Canonical and Noncanonical Inflammasome via TLR4/NF‐κB Pathway

(2019) Xin Zhong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders

(2019) Sandeep Kumar Singh et al.   Neurotherapeutics

Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor

(2019) Koji Ozasa et al.   Frontiers in Immunology

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

(2019) Alessandra Webers et al.   IMMUNOLOGY AND CELL BIOLOGY

Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity

(2019) Jiong Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice

(2019) Miren Ettcheto et al.   MOLECULAR NEUROBIOLOGY

Custom-Made Ceria Nanoparticles Show a Neuroprotective Effect by Modulating Phenotypic Polarization of the Microglia

(2018) Feng Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Neuroprotective effects of coenzyme Q10 on paraquat-induced Parkinson’s disease in experimental animals

(2018) Hanan Naeim Attia et al.   BEHAVIOURAL PHARMACOLOGY

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects

(2018) Hang Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A nonmyeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma

(2018) K. Yu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders

(2018) Adaze Bijou Enogieru et al.   Oxidative Medicine and Cellular Longevity

Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

(2018) Olesia Ignatenko et al.   Nature Communications

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

Extracellular vesicles are increased in the serum of children with autism spectrum disorder, contain mitochondrial DNA, and stimulate human microglia to secrete IL-1β

(2018) Irene Tsilioni et al.   Journal of Neuroinflammation

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Inflammasome signalling in brain function and neurodegenerative disease

(2018) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

(2017) Cyra E Leurs et al.   Multiple Sclerosis Journal

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Cerebrospinal fluid mitochondrial DNA in the Alzheimer's disease continuum

(2017) Laura Cervera-Carles et al.   NEUROBIOLOGY OF AGING

Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation

(2017) Vidhu Mathur et al.   NEURON

Mitochondria in neuroinflammation – Multiple sclerosis (MS), leber hereditary optic neuropathy (LHON) and LHON-MS

(2017) David Bargiela et al.   NEUROSCIENCE LETTERS

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

(2017) Pasquale Sansone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

(2017) Michael G. Erkkinen et al.   Cold Spring Harbor Perspectives in Biology

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment

(2017) Cyra E Leurs et al.   Multiple Sclerosis Journal

Neurodegenerative diseases

(2016) Marie-Thérèse Heemels   NATURE

Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds

(2016) Isabel Denzer et al.   PHARMACOLOGICAL RESEARCH

Targeting Oxidative Stress in Central Nervous System Disorders

(2016) Manisha Patel   TRENDS IN PHARMACOLOGICAL SCIENCES

Resveratrol: A Focus on Several Neurodegenerative Diseases

(2015) Ester Tellone et al.   Oxidative Medicine and Cellular Longevity

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases

(2015) Hiromi Yamazaki et al.   PATHOLOGY INTERNATIONAL

H2S- and NO-Signaling Pathways in Alzheimer's Amyloid Vasculopathy: Synergism or Antagonism?

(2015) Alla B. Salmina et al.   Frontiers in Physiology

Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease

(2013) Petar Podlesniy et al.   ANNALS OF NEUROLOGY

Nucleic acid oxidation: an early feature of Alzheimer's disease

(2013) Melissa A. Bradley-Whitman et al.   JOURNAL OF NEUROCHEMISTRY

Hydrogen sulfide slows down progression of experimental Alzheimer’s disease by targeting multiple pathophysiological mechanisms

(2013) Daniela Giuliani et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

(2013) Samantha Giordano et al.   Redox Biology

Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3β and CREB through PI3-K/Akt pathways

(2012) Fabrício Simão et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Long-term use of standardised ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial

(2012) Bruno Vellas et al.   LANCET NEUROLOGY

Neuroprotective Actions of Flavonoids

(2011) C. Gutierrez-Merino et al.   CURRENT MEDICINAL CHEMISTRY

The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior

(2011) Hiroshi Nakanishi et al.   Neuron Glia Biology

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Dietary supplementation with tBHQ, an Nrf2 stabilizer molecule, confers neuroprotection against apoptosis in amyloid beta-injected rat

(2010) Solaleh Khoramian Tusi et al.   JOURNAL OF BIOTECHNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid β formation in NT2N neurons

(2009) Bahareh Eftekharzadeh et al.   BIOCHIMIE