Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging

Reduced peroxisomal import triggers peroxisomal retrograde signaling

(2021) Elisabeth Rackles et al.   Cell Reports

Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans

(2021) Paola Sebastiani et al.   AGING CELL

Peroxisomes as Cellular Adaptors to Metabolic and Environmental Stress

(2021) Anyuan He et al.   TRENDS IN CELL BIOLOGY

Mechanisms and Functions of Pexophagy in Mammalian Cells

(2021) Jing Li et al.   Cells

Autophagy Inhibitors Do Not Restore Peroxisomal Functions in Cells With the Most Common Peroxisome Biogenesis Defect

(2021) Femke C. C. Klouwer et al.   Frontiers in Cell and Developmental Biology

Pexophagy: A Model for Selective Autophagy

(2020) Kyla Germain et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation

(2020) Anyuan He et al.   MOLECULAR CELL

TheTMEM189gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens

(2020) Ernst R. Werner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation

(2020) Anyuan He et al.   Autophagy

Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine

(2020) Kerui Huang et al.   Nature Communications

Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases

(2020) Doo Sin Jo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors

(2020) Sven Francque et al.   Nature Reviews Gastroenterology & Hepatology

Serum very long-chain fatty acids (VLCFA) levels as predictive biomarkers of diseases severity and probability of survival in peroxisomal disorders

(2020) Teresa Joanna Stradomska et al.   PLoS One

Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum

(2020) Masanori Honsho et al.   Frontiers in Cell and Developmental Biology

When Friendship Turns Sour: Effective Communication Between Mitochondria and Intracellular Organelles in Parkinson's Disease

(2020) Tsu-Kung Lin et al.   Frontiers in Cell and Developmental Biology

RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress

(2019) Kerui Huang et al.   BMC GENOMICS

Organelle Interplay - Peroxisome Interactions in Health and Disease

(2019) Michael Schrader et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis

(2019) Hideaki Tanaka et al.   JOURNAL OF CELL SCIENCE

Functional peroxisomes are required for β-cell integrity in mice

(2019) Ritesh Kumar Baboota et al.   Molecular Metabolism

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

(2019) Sandra Elizabeth Torres et al.   eLife

Impaired peroxisomal fitness in obese mice, a vicious cycle exacerbating adipocyte dysfunction via oxidative stress

(2019) Lingjuan Piao et al.   ANTIOXIDANTS & REDOX SIGNALING

A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis

(2019) Aránzazu Gallego-García et al.   SCIENCE

The impaired redox balance in peroxisomes of catalase knockout mice accelerates nonalcoholic fatty liver disease through endoplasmic reticulum stress

(2019) Inah Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The N-terminal amphipathic helix of Pex11p self-interacts to induce membrane remodelling during peroxisome fission

(2018) Juanjuan Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Disruption of peroxisome function leads to metabolic stress, mTOR inhibition, and lethality in liver cancer cells

(2018) Mengjiao Cai et al.   CANCER LETTERS

Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants

(2018) Margret H. Bülow et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

(2018) Nadav Shai et al.   Nature Communications

Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants

(2018) Julia Sellin et al.   PLOS BIOLOGY

Potential Roles of Peroxisomes in Alzheimer's Disease and in Dementia of the Alzheimer's Type

(2018) Gérard Lizard et al.   JOURNAL OF ALZHEIMERS DISEASE

Peroxisome Proliferators Reduce Spatial Memory Impairment, Synaptic Failure, and Neurodegeneration in Brains of a Double Transgenic Mice Model of Alzheimer's Disease

(2018) Nibaldo C. Inestrosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission

(2018) Hongsuk Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Catalase deletion promotes prediabetic phenotype in mice

(2017) Claire Heit et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Peroxisome-Mitochondria Connection: How and Why?

(2017) Marc Fransen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis

(2017) Rong Hua et al.   JOURNAL OF CELL BIOLOGY

ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER

(2017) Joseph L. Costello et al.   JOURNAL OF CELL BIOLOGY

Functional characterisation of peroxisomal β-oxidation disorders in fibroblasts using lipidomics

(2017) Katharina Herzog et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes

(2017) Ayumu Sugiura et al.   NATURE

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Peroxisomal Dysfunction in Age-Related Diseases

(2017) Cynthia M. Cipolla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Structural and functional roles of ether lipids

(2017) John M. Dean et al.   Protein & Cell

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

(2017) Sandra Kleinecke et al.   eLife

Early Biochemical and Morphological Modifications in the Brain of a Transgenic Mouse Model of Alzheimer's Disease: A Role for Peroxisomes

(2017) AnnaMaria Cimini et al.   JOURNAL OF ALZHEIMERS DISEASE

Obesity and related consequences to ageing

(2016) Magdalena Jura et al.   AGE

Autophagic degradation of peroxisomes in mammals

(2016) Katarzyna Zientara-Rytter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of peroxisomal matrix protein import by ubiquitination

(2016) Harald W. Platta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hepatic dysfunction in peroxisomal disorders

(2016) Myriam Baes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Peroxisomes in brain development and function

(2016) Johannes Berger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human disorders of peroxisome metabolism and biogenesis

(2016) Hans R. Waterham et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ACBD5 deficiency causes a defect in peroxisomal very long-chain fatty acid metabolism

(2016) Sacha Ferdinandusse et al.   JOURNAL OF MEDICAL GENETICS

ACBD2/ECI2-Mediated Peroxisome-Mitochondria Interactions in Leydig Cell Steroid Biosynthesis

(2016) Jinjiang Fan et al.   MOLECULAR ENDOCRINOLOGY

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

(2016) Ciara M Gallagher et al.   eLife

The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults

(2016) William E Barry et al.   eLife

Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress

(2016) Ciara M Gallagher et al.   eLife

Deep Proteome Analysis Identifies Age-Related Processes in C. elegans

(2016) Vikram Narayan et al.   Cell Systems

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation

(2015) Annelies Peeters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Close Encounters of the Lysosome-Peroxisome Kind

(2015) Yui Jin et al.   CELL

Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

(2015) Bei-Bei Chu et al.   CELL

Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis

(2015) Dongyan Tan et al.   FEBS Journal

Genome-Wide Localization Study of Yeast Pex11 Identifies Peroxisome–Mitochondria Interactions through the ERMES Complex

(2015) M. Mattiazzi Ušaj et al.   JOURNAL OF MOLECULAR BIOLOGY

The Pex1/Pex6 Complex Is a Heterohexameric AAA + Motor with Alternating and Highly Coordinated Subunits

(2015) Brooke M. Gardner et al.   JOURNAL OF MOLECULAR BIOLOGY

Zellweger spectrum disorders: clinical overview and management approach

(2015) Femke C. C. Klouwer et al.   Orphanet Journal of Rare Diseases

Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling

(2015) Gani Oruqaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy

(2015) Neil B. Blok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisomes in cardiomyocytes and the peroxisome / peroxisome proliferator-activated receptor-loop

(2015) Claudia Colasante et al.   THROMBOSIS AND HAEMOSTASIS

Molecular snapshots of the Pex1/6 AAA+ complex in action

(2015) Susanne Ciniawsky et al.   Nature Communications

Pex11mediates peroxisomal proliferation by promoting deformation of the lipid membrane

(2015) Y. Yoshida et al.   Biology Open

Peroxisomal dysfunction is associated with up-regulation of apoptotic cell death via miR-223 induction in knee osteoarthritis patients with type 2 diabetes mellitus

(2014) Dongkyun Kim et al.   BONE

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

(2014) Irfan J. Lodhi et al.   Cell Metabolism

Cholesterol biosynthesis and ER stress in peroxisome deficiency

(2013) Phyllis L. Faust et al.   BIOCHIMIE

Metabolic functions of peroxisomes in health and disease

(2013) Ronald J.A. Wanders   BIOCHIMIE

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

(2013) J. López-Erauskin et al.   HUMAN MOLECULAR GENETICS

Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease

(2013) Francesca Fanelli et al.   Molecular Neurodegeneration

Correction: The Proteome of Human Liver Peroxisomes: Identification of Five New Peroxisomal Constituents by a Label-Free Quantitative Proteomics Survey

(2013) Thomas Gronemeyer et al.   PLoS One

Mff functions with Pex11p  and DLP1 in peroxisomal fission

(2013) A. Itoyama et al.   Biology Open

Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease

(2012) Dao-Fu Dai et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice

(2012) Werner J. Kovacs et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Peroxisomes, cell senescence, and rates of aging

(2012) Courtney R. Giordano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Biochemically Distinct Vesicles from the Endoplasmic Reticulum Fuse to Form Peroxisomes

(2012) Adabella van der Zand et al.   CELL

Catalase Deficiency Accelerates Diabetic Renal Injury Through Peroxisomal Dysfunction

(2012) I. Hwang et al.   DIABETES

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Adaptive Response, Evidence of Cross-Resistance and Its Potential Clinical Use

(2012) Irina Milisav et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Ubiquitin-specific Protease 9X (USP9X) as a Deubiquitinase Acting on Ubiquitin-Peroxin 5 (PEX5) Thioester Conjugate

(2012) Cláudia P. Grou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division

(2012) A. Itoyama et al.   JOURNAL OF CELL SCIENCE

A novel defect of peroxisome division due to a homozygous non-sense mutation in thePEX11βgene

(2012) Merel S Ebberink et al.   JOURNAL OF MEDICAL GENETICS

The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked by Prominent RNA Oxidation in Vulnerable Neurons

(2012) Akihiko Nunomura et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inhibition of peroxisomal β-oxidation by thioridazine increases the amount of VLCFAs and Aβ generation in the rat brain

(2012) Ruling Shi et al.   NEUROSCIENCE LETTERS

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

(2012) Thomas D. Baird et al.   Advances in Nutrition

Effects of peroxisomal catalase inhibition on mitochondrial function

(2012) Paul A. Walton   Frontiers in Physiology

Peroxisomal alterations in Alzheimer’s disease

(2011) Jianqiu Kou et al.   ACTA NEUROPATHOLOGICA

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deletion of a single allele of the Pex11  gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain

(2011) B. Ahlemeyer et al.   Disease Models & Mechanisms

Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy

(2011) Agatha Schlüter et al.   HUMAN MOLECULAR GENETICS

Carbohydrate Metabolism Is Perturbed in Peroxisome-deficient Hepatocytes Due to Mitochondrial Dysfunction, AMP-activated Protein Kinase (AMPK) Activation, and Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Suppression

(2011) Annelies Peeters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubp15p, a Ubiquitin Hydrolase Associated with the Peroxisomal Export Machinery

(2011) Mykhaylo O. Debelyy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

(2011) Oksana Ivashchenko et al.   MOLECULAR BIOLOGY OF THE CELL

Alkyl-Glycerol Rescues Plasmalogen Levels and Pathology of Ether-Phospholipid Deficient Mice

(2011) Pedro Brites et al.   PLoS One

Protein import machineries of peroxisomes

(2010) Robert Rucktäschel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Be different—The diversity of peroxisomes in the animal kingdom

(2010) M. Islinger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

General Aspects and Neuropathology of X-Linked Adrenoleukodystrophy

(2010) Isidro Ferrer et al.   BRAIN PATHOLOGY

Membrane curvature during peroxisome fission requires Pex11

(2010) Łukasz Opaliński et al.   EMBO JOURNAL

The peroxisomal importomer constitutes a large and highly dynamic pore

(2010) Michael Meinecke et al.   NATURE CELL BIOLOGY

Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

(2010) Giuseppe Astarita et al.   PLoS One

Peroxisome Metabolism and Cellular Aging

(2010) Vladimir I. Titorenko et al.   TRAFFIC

Peroxisome Proliferator-Activated Receptor Alpha Target Genes

(2010) Maryam Rakhshandehroo et al.   PPAR Research

Reactive oxygen species and peroxisomes: Struggling for balance

(2009) Nina A. Bonekamp et al.   BIOFACTORS

Drosophila HNF4 Regulates Lipid Mobilization and β-Oxidation

(2009) Laura Palanker et al.   Cell Metabolism

Cardiac-Specific Overexpression of Catalase Identifies Hydrogen Peroxide-Dependent and -Independent Phases of Myocardial Remodeling and Prevents the Progression to Overt Heart Failure in Gαq-Overexpressing Transgenic Mice

(2009) Fuzhong Qin et al.   Circulation-Heart Failure

The Burden of Cardiovascular Disease in the Elderly: Morbidity, Mortality, and Costs

(2009) Ali Yazdanyar et al.   CLINICS IN GERIATRIC MEDICINE

Degradation of excess peroxisomes in mammalian liver cells by autophagy and other mechanisms

(2009) Sadaki Yokota et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Pex2 and Pex12 Function as Protein-Ubiquitin Ligases in Peroxisomal Protein Import

(2009) H. W. Platta et al.   MOLECULAR AND CELLULAR BIOLOGY

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

(2009) Maryam Rakhshandehroo et al.   PLoS One

Peroxisome Dynamics in Cultured Mammalian Cells

(2009) Sofie J. Huybrechts et al.   TRAFFIC

Hitchhiking of Cu/Zn Superoxide Dismutase to Peroxisomes - Evidence for a Natural Piggyback Import Mechanism in Mammals

(2009) Markus Islinger et al.   TRAFFIC

The peroxisomal protein import machinery – a case report of transient ubiquitination with a new flavor

(2008) C. P. Grou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cargo-Selected Transport from the Mitochondria to Peroxisomes Is Mediated by Vesicular Carriers

(2008) Margaret Neuspiel et al.   CURRENT BIOLOGY

Obesity and aging have divergent genomic fingerprints

(2008) S Miard et al.   INTERNATIONAL JOURNAL OF OBESITY

Peroxisome Deficiency Causes a Complex Phenotype because of Hepatic SREBP/Insig Dysregulation Associated with Endoplasmic Reticulum Stress

(2008) Werner J. Kovacs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p- and Pex16p-dependent pathway

(2008) Takashi Matsuzaki et al.   JOURNAL OF CELL BIOLOGY