Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease

Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis

(2019) Lorena Fernandez-Mosquera et al.   Autophagy

Endoplasmic Reticulum Stress-induced Upregulation of STARD1 Promotes Acetaminophen-induced Acute Liver Failure

(2019) Sandra Torres et al.   GASTROENTEROLOGY

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

(2019) King Faisal Yambire et al.   eLife

Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes

(2019) Estel Solsona-Vilarrasa et al.   Redox Biology

Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion

(2018) Elisabet Barbero-Camps et al.   Autophagy

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

(2018) Qi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration

(2017) Fabian Arenas et al.   Frontiers in Molecular Neuroscience

MLN64 induces mitochondrial dysfunction associated with increased mitochondrial cholesterol content

(2017) Elisa Balboa et al.   Redox Biology

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease

(2017) Sandra Torres et al.   Redox Biology

Mitochondrial metabolic regulation by GRP78

(2017) Manoj Prasad et al.   Science Advances

Mitochondria-Associated Membranes As Networking Platforms and Regulators of Cancer Cell Fate

(2017) Maria Livia Sassano et al.   Frontiers in Oncology

Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease

(2016) Marcin Woś et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies

(2016) Anat Boehm-Cagan et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins

(2016) Anat Boehm-Cagan et al.   PLoS One

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

ApoE4 upregulates the activity of mitochondria-associated ER membranes

(2015) M. D. Tambini et al.   EMBO REPORTS

Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy

(2015) Anna Baulies et al.   Scientific Reports

Endoplasmic Reticulum Stress Mediates Amyloid β Neurotoxicity via Mitochondrial Cholesterol Trafficking

(2014) Elisabet Barbero-Camps et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

(2014) A.I. Plácido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents

(2014) M. G. Martin et al.   EMBO Molecular Medicine

Cholesterol in brain disease: sometimes determinant and frequently implicated

(2014) M. G. Martin et al.   EMBO REPORTS

Adaptations of Energy Metabolism Associated with Increased Levels of Mitochondrial Cholesterol in Niemann-Pick Type C1-deficient Cells

(2014) Barry E. Kennedy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex lipid trafficking in Niemann-Pick disease type C

(2014) Marie T. Vanier   JOURNAL OF INHERITED METABOLIC DISEASE

Sphingolipid lysosomal storage disorders

(2014) Frances M. Platt   NATURE

ABCA7 gene and the risk of Alzheimer's disease in Han Chinese in Taiwan

(2014) Yi-Chu Liao et al.   NEUROBIOLOGY OF AGING

Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of Niemann–Pick disease, type C1

(2013) Rao Fu et al.   HUMAN MOLECULAR GENETICS

APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease

(2013) Elisabet Barbero-Camps et al.   HUMAN MOLECULAR GENETICS

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading

(2013) Anna Fernandez et al.   JOURNAL OF HEPATOLOGY

Identification of Niemann-Pick C1 disease biomarkers through sphingolipid profiling

(2013) Martin Fan et al.   JOURNAL OF LIPID RESEARCH

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Endoplasmic reticulum: The unfolded protein response is tangled in neurodegeneration

(2012) Jeroen J.M. Hoozemans et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Acid Ceramidase (ASAH1) Represses Steroidogenic Factor 1-Dependent Gene Transcription in H295R Human Adrenocortical Cells by Binding to the Receptor

(2012) N. C. Lucki et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondria-associated ER membranes in Alzheimer disease

(2012) Eric A. Schon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Recommendations for the diagnosis and management of Niemann–Pick disease type C: An update

(2012) Marc C. Patterson et al.   MOLECULAR GENETICS AND METABOLISM

Steroidogenic Acute Regulatory Protein Expression in the Central Nervous System

(2011) Steven R. King et al.   Frontiers in Endocrinology

Higher Incidence of Mild Cognitive Impairment in Familial Hypercholesterolemia

(2010) Daniel Zambón et al.   AMERICAN JOURNAL OF MEDICINE

Lack of Activation of the Unfolded Protein Response in Mouse and Cellular Models of Niemann-Pick Type C Disease

(2010) Andres Klein et al.   Neurodegenerative Diseases

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Cholesterol Loading Exacerbates Amyloid   Peptide-Induced Inflammation and Neurotoxicity

(2009) A. Fernandez et al.   JOURNAL OF NEUROSCIENCE

Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis

(2009) K. Saito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE