The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas

(2012) G. Jin et al.   CANCER RESEARCH

Synthesis of the 1-Monoester of 2-Ketoalkanedioic Acids, for Example, Octyl α-Ketoglutarate

(2012) Michael E. Jung et al.   JOURNAL OF ORGANIC CHEMISTRY

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Metabolomics Approach for Analyzing the Effects of Exercise in Subjects with Type 1 Diabetes Mellitus

(2012) Laura Brugnara et al.   PLoS One

Coordinate Regulation of Lipid Metabolism by Novel Nuclear Receptor Partnerships

(2012) Pranali P. Pathare et al.   PLoS Genetics

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

(2011) Hiroyasu Yamamoto et al.   CELL

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

(2011) Mark Lucanic et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria

(2011) George W. Rogers et al.   PLoS One

Identification of Direct Protein Targets of Small Molecules

(2010) Brett Lomenick et al.   ACS Chemical Biology

The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans

(2010) Adriana Alberti et al.   Autophagy

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Oxaloacetate supplementation increases lifespan inCaenorhabditis elegansthrough an AMPK/FOXO-dependent pathway

(2009) David S. Williams et al.   AGING CELL

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways inC. elegans

(2009) Eric L. Greer et al.   AGING CELL

The TOR pathway comes of age

(2009) Monique N. Stanfel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure

(2009) Christopher J. Stubbs et al.   JOURNAL OF MEDICINAL CHEMISTRY

C. elegans behavior of preference choice on bacterial food

(2009) Emad Abd-elmoniem Abada et al.   MOLECULES AND CELLS

The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

(2009) Yi Zhang et al.   PLoS One

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

(2008) Karyn L. Sheaffer et al.   CURRENT BIOLOGY

Expanding chemical biology of 2-oxoglutarate oxygenases

(2008) Christoph Loenarz et al.   Nature Chemical Biology

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics