Impact of cancer metabolism on therapy resistance – Clinical implications
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Title
Impact of cancer metabolism on therapy resistance – Clinical implications
Authors
Keywords
Cancer metabolism, Therapy resistance, Tumor microenvironment, Intratumor heterogeneity, Metabolic plasticity, Glycolysis, Oxidative phosphorylation
Journal
DRUG RESISTANCE UPDATES
Volume 59, Issue -, Pages 100797
Publisher
Elsevier BV
Online
2021-12-16
DOI
10.1016/j.drup.2021.100797
References
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Note: Only part of the references are listed.- Overcoming PARPi resistance: preclinical and clinical evidence in ovarian cancer
- (2021) M. Chiappa et al. DRUG RESISTANCE UPDATES
- Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress
- (2021) Christophe Olivier et al. Frontiers in Molecular Biosciences
- Cancer Immunotherapy Update: FDA-Approved Checkpoint Inhibitors and Companion Diagnostics
- (2021) Julianne D. Twomey et al. AAPS Journal
- Exogenous and endogenous sources of serine contribute to colon cancer metabolism, growth, and resistance to 5-fluorouracil
- (2021) David C. Montrose et al. CANCER RESEARCH
- Immuno-Metabolism: The Role of Cancer Niche in Immune Checkpoint Inhibitor Resistance
- (2021) Chao-Yuan Weng et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Glycolysis-induced drug resistance in tumors—A response to danger signals?
- (2021) Fabrizio Marcucci et al. NEOPLASIA
- Extracellular Vesicle-Mediated Chemoresistance in Oral Squamous Cell Carcinoma
- (2021) Zhu-Jun Law et al. Frontiers in Molecular Biosciences
- HMGCS1 drives drug-resistance in acute myeloid leukemia through endoplasmic reticulum-UPR-mitochondria axis
- (2021) Cheng Zhou et al. BIOMEDICINE & PHARMACOTHERAPY
- Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
- (2021) Lucille Stuani et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling
- (2021) Jing Cui et al. MOLECULAR MEDICINE
- Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer
- (2021) Samantha A. Hutchinson et al. ONCOGENE
- Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia
- (2021) Feng Wang et al. Nature Communications
- Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
- (2021) Emily L. Giddings et al. Nature Communications
- Integration of machine learning and genome-scale metabolic modeling identifies multi-omics biomarkers for radiation resistance
- (2021) Joshua E. Lewis et al. Nature Communications
- Advanced bioinformatic analysis and pathway prediction of NSCLC cells upon cisplatin resistance
- (2021) A K M Nawshad Hossian et al. Scientific Reports
- Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck
- (2021) Dan P Zandberg et al. Journal for ImmunoTherapy of Cancer
- Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance
- (2021) Abdessamad El Kaoutari et al. EBioMedicine
- Role of Reductive versus Oxidative Stress in Tumor Progression and Anticancer Drug Resistance
- (2021) Kyung-Soo Chun et al. Cells
- Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells
- (2021) Jonathan Tucci et al. Frontiers in Oncology
- Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role
- (2021) Giuseppina Barrera et al. Antioxidants
- Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer
- (2021) Asmaa El-Kenawi et al. CANCER RESEARCH
- Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects
- (2021) Emeline Dierge et al. Cell Metabolism
- Prothymosin α promotes colorectal carcinoma chemoresistance through inducing lipid droplet accumulation
- (2021) Long Jin et al. MITOCHONDRION
- Microenvironment-triggered multimodal precision diagnostics
- (2021) Liangliang Hao et al. NATURE MATERIALS
- Amino Acid Depletion Therapies: Starving Cancer Cells to Death
- (2021) Miriam Butler et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition
- (2021) Catherine Vander Linden et al. Cell Reports
- Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer
- (2021) Shawn McGuirk et al. eLife
- USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis
- (2021) Ruize Gao et al. Oncogenesis
- Stromal Cells Serve Drug Resistance for Multiple Myeloma via Mitochondrial Transfer: A Study on Primary Myeloma and Stromal Cells
- (2021) Zsolt Matula et al. Cancers
- An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor
- (2021) Yukari Shirai et al. Cancers
- Epigenetic Deregulation of Apoptosis in Cancers
- (2021) Ezgi Ozyerli-Goknar et al. Cancers
- Metabolic Reprogramming: A Friend or Foe to Cancer Therapy?
- (2021) Christopher McCann et al. Cancers
- The Role of Glucose Transporters in Oral Squamous Cell Carcinoma
- (2021) Heinrich Botha et al. Biomolecules
- The Role of Tumour Metabolism in Cisplatin Resistance
- (2021) Lude Wang et al. Frontiers in Molecular Biosciences
- The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer
- (2021) Zhijian Jin et al. Redox Biology
- Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers
- (2020) Suman Mukhopadhyay et al. CANCER RESEARCH
- Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo
- (2020) Juan Fernández-García et al. TRENDS IN BIOCHEMICAL SCIENCES
- TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
- (2020) Cyril Corbet et al. Nature Communications
- Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
- (2020) Nobu Oshima et al. Cell Reports
- Modulation of Mitochondrial Metabolic Reprogramming and Oxidative Stress to Overcome Chemoresistance in Cancer
- (2020) Rosario Avolio et al. Biomolecules
- Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells
- (2020) Marco Cordani et al. Biomolecules
- Acquired Resistance to Immune Checkpoint Inhibitors
- (2020) Adam J. Schoenfeld et al. CANCER CELL
- ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase
- (2020) Robert T. Williams et al. Cell Metabolism
- Lysophosphatidic acid receptor-2 (LPA2)-mediated signaling enhances chemoresistance in melanoma cells treated with anticancer drugs
- (2020) Kanako Minami et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism
- (2020) Di Yu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic reprogramming and cancer progression
- (2020) Brandon Faubert et al. SCIENCE
- GLUT1/3/4 as novel biomarkers for the prognosis of human breast cancer
- (2020) Kai Zeng et al. Translational Cancer Research
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- (2020) Natalia Trempolec et al. Cancers
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- (2020) Dimas Carolina Belisario et al. Cells
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- (2020) Michal Stark et al. Cells
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- (2020) Xiaodong Sun et al. BIOCHEMICAL PHARMACOLOGY
- Oxidative Stress in Cancer
- (2020) John D. Hayes et al. CANCER CELL
- Functional diversity of cancer‐associated fibroblasts in modulating drug resistance
- (2020) Luke Bu et al. CANCER SCIENCE
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- (2020) Masanori Takehara et al. CANCER SCIENCE
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- (2020) Nick van Gastel et al. Cell Metabolism
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- (2020) Jackie E. Bader et al. MOLECULAR CELL
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- (2020) Robert A. Gatenby et al. Nature Reviews Clinical Oncology
- Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways
- (2020) Ioannis K. Zervantonakis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors
- (2020) Kangjing Xu et al. Cell Death & Disease
- Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery
- (2020) F. J. Voskuil et al. Nature Communications
- Machine learning of serum metabolic patterns encodes early-stage lung adenocarcinoma
- (2020) Lin Huang et al. Nature Communications
- Mechanisms of Cancer Resistance to Immunotherapy
- (2020) Rilan Bai et al. Frontiers in Oncology
- Imaging Mass Spectrometry Reveals Tumor Metabolic Heterogeneity
- (2020) Yang Zhang et al. iScience
- Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives
- (2020) Mir Mohd Faheem et al. Cell Death Discovery
- Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition
- (2020) Federica Iannelli et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells
- (2020) Elena Andreucci et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Usefulness of 18F-FDOPA PET for the management of primary brain tumors: a systematic review of the literature
- (2020) François Somme et al. CANCER IMAGING
- PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers
- (2020) Rui Liu et al. Cell Death & Disease
- The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma
- (2020) Zhongqiang Zhang et al. Cell Death & Disease
- mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
- (2020) Niklas Gremke et al. Nature Communications
- Metabolic Signaling Cascades Prompted by Glutaminolysis in Cancer
- (2020) Raj Shah et al. Cancers
- Role of Glutathione in Cancer: From Mechanisms to Therapies
- (2020) Luke Kennedy et al. Biomolecules
- Integrative Analysis of Hypoxia-Associated Signature in Pan-Cancer
- (2020) Qian Zhang et al. iScience
- Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies
- (2020) Elisabeth Pérez-Ruiz et al. DRUG RESISTANCE UPDATES
- Environmental control of mammary carcinoma cell expansion by acidification and spheroid formation in vitro
- (2020) Ana Carolina Lima Ralph et al. Scientific Reports
- Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities
- (2020) Bryce Ordway et al. Cancers
- Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance
- (2020) Dimas Carolina Belisario et al. Cells
- Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine
- (2020) Cristina P.R. Xavier et al. CANCER LETTERS
- Targeting Mitochondria for Treatment of Chemoresistant Ovarian Cancer
- (2019) Edith Emmings et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Therapeutic Targeting of Cancer Stem Cells: Integrating and Exploiting the Acidic Niche
- (2019) Catherine Vander Linden et al. Frontiers in Oncology
- Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
- (2019) Shuo Qie et al. Nature Communications
- Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma
- (2019) Prashant Mujumdar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting Tumor Microenvironment for Cancer Therapy
- (2019) Catarina Roma-Rodrigues et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tissue 2-hydroxyglutarate as a biomarker for isocitrate dehydrogenase (IDH) mutations in gliomas
- (2019) Hao-Wen Sim et al. CLINICAL CANCER RESEARCH
- Current perspectives of cancer-associated fibroblast in therapeutic resistance: potential mechanism and future strategy
- (2019) Dhruba Kadel et al. CELL BIOLOGY AND TOXICOLOGY
- Mitochondrial pyruvate carrier 1 expression controls cancer EMT and radioresistance
- (2019) Yuji Takaoka et al. CANCER SCIENCE
- Causes, consequences, and therapy of tumors acidosis
- (2019) Smitha R. Pillai et al. CANCER AND METASTASIS REVIEWS
- Pro-metastatic functions of lipoproteins and extracellular vesicles in the acidic tumor microenvironment
- (2019) Anna Bång-Rudenstam et al. CANCER AND METASTASIS REVIEWS
- Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?
- (2019) Zahra Ghanbari Movahed et al. BIOMEDICINE & PHARMACOTHERAPY
- Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition
- (2019) Alberto Cruz-Bermúdez et al. FREE RADICAL BIOLOGY AND MEDICINE
- Methionine is a metabolic dependency of tumor-initiating cells
- (2019) Zhenxun Wang et al. NATURE MEDICINE
- The miR-186-3p/EREG axis orchestrates tamoxifen resistance and aerobic glycolysis in breast cancer cells
- (2019) Mengjia He et al. ONCOGENE
- Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state
- (2019) Gloria V. Echeverria et al. Science Translational Medicine
- Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma
- (2019) Liang Zhang et al. Science Translational Medicine
- Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
- (2019) José M. Matés et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Mitochondrial metabolism: Inducer or therapeutic target in tumor immune-resistance?
- (2019) Joanna Kopecka et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Reconciling environment-mediated metabolic heterogeneity with the oncogene-driven cancer paradigm in precision oncology
- (2019) Catherine Vander Linden et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Surmounting Cytarabine-resistance in acute myeloblastic leukemia cells and specimens with a synergistic combination of hydroxyurea and azidothymidine
- (2019) May Levin et al. Cell Death & Disease
- Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
- (2019) Mark R Sullivan et al. eLife
- The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances
- (2019) Pouya Saraei et al. Cancer Management and Research
- Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer
- (2019) Subbroto Saha et al. Journal of Clinical Medicine
- Modulation of chemoresistance by lysophosphatidic acid (LPA) signaling through LPA5 in melanoma cells treated with anticancer drugs
- (2019) Kanako Minami et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Immune checkpoint inhibitor combinations: Current efforts and important aspects for success
- (2019) Edo Kon et al. DRUG RESISTANCE UPDATES
- Phenformin as an Anticancer Agent: Challenges and Prospects
- (2019) Rubiño et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Adipocyte and lipid metabolism in cancer drug resistance
- (2019) Yihai Cao JOURNAL OF CLINICAL INVESTIGATION
- MPC1 deletion is associated with poor prognosis and temozolomide resistance in glioblastoma
- (2019) Yi Chai et al. JOURNAL OF NEURO-ONCOLOGY
- Dietary methionine influences therapy in mouse cancer models and alters human metabolism
- (2019) Xia Gao et al. NATURE
- MYC Expression and Metabolic Redox Changes in Cancer Cells: A Synergy Able to Induce Chemoresistance
- (2019) Barbara Marengo et al. Oxidative Medicine and Cellular Longevity
- Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer
- (2019) Matteo Morotti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MicroRNA signature refine response prediction in CML
- (2019) Raquel Alves et al. Scientific Reports
- Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
- (2019) Yuetong Wang et al. Cell Reports
- Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer
- (2019) Marina Bacci et al. Cell Reports
- Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair
- (2019) Shujun Fu et al. Cell Reports
- The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?
- (2019) Diana Vara-Ciruelos et al. Open Biology
- PET imaging of occult tumours by temporal integration of tumour-acidosis signals from pH-sensitive 64Cu-labelled polymers
- (2019) Gang Huang et al. Nature Biomedical Engineering
- Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment
- (2019) Tianyi Liu et al. Frontiers in Cell and Developmental Biology
- Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies
- (2019) Romain Guièze et al. CANCER CELL
- The emergence of drug resistance to targeted therapies: Clinical evidence
- (2019) Ana Bela Sarmento-Ribeiro et al. DRUG RESISTANCE UPDATES
- The multi-factorial nature of clinical multidrug resistance in cancer
- (2019) Yehuda G. Assaraf et al. DRUG RESISTANCE UPDATES
- Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer
- (2019) Alessandro Leonetti et al. DRUG RESISTANCE UPDATES
- SLC 1A3 contributes to L‐asparaginase resistance in solid tumors
- (2019) Jianhui Sun et al. EMBO JOURNAL
- Simvastatin Increases Temozolomide‐induced Cell Death by Targeting the Fusion of Autophagosomes and Lysosomes
- (2019) Shahla Shojaei et al. FEBS Journal
- A unique morphological phenotype in chemoresistant triple negative breast cancer reveals metabolic reprogramming and PLIN4 expression as a molecular vulnerability
- (2019) Isabelle Sirois et al. MOLECULAR CANCER RESEARCH
- Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer
- (2019) Tzu-Tang Wei et al. ONCOGENE
- Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance
- (2019) Aaron Goldman et al. Science Signaling
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- (2019) Diane M. Demas et al. Frontiers in Oncology
- The Acidic Tumor Microenvironment as a Driver of Cancer
- (2019) Ebbe Boedtkjer et al. Annual Review of Physiology
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- (2019) Richard Burt et al. BLOOD
- Localized metabolomic gradients in patient-derived xenograft models of glioblastoma
- (2019) Elizabeth C Randall et al. CANCER RESEARCH
- Dysregulation of glutamate transport enhances Treg function that promotes VEGF blockade resistance in glioblastoma
- (2019) Yu Long et al. CANCER RESEARCH
- Targeting metabolic dependencies in pediatric cancer
- (2019) Sameer H. Issaq et al. CURRENT OPINION IN PEDIATRICS
- A view on drug resistance in cancer
- (2019) Neil Vasan et al. NATURE
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- (2019) Soufiane Boumahdi et al. NATURE REVIEWS DRUG DISCOVERY
- Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
- (2019) Lai Wei et al. Nature Communications
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- (2019) Ahmed Lasfar et al. Frontiers in Oncology
- Targeting Cell Metabolism as Cancer Therapy
- (2019) Natalie Y.L. Ngoi et al. ANTIOXIDANTS & REDOX SIGNALING
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- (2019) Hee Chan Yoo et al. Cell Metabolism
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- (2019) Joanna Kopecka et al. DRUG RESISTANCE UPDATES
- 11C-choline PET/CT in recurrent prostate cancer: retrospective analysis in a large US patient series
- (2019) Laure Michaud et al. JOURNAL OF NUCLEAR MEDICINE
- Understanding of ROS-Inducing Strategy in Anticancer Therapy
- (2019) Su Ji Kim et al. Oxidative Medicine and Cellular Longevity
- Impairing energy metabolism in solid tumors through agents targeting oncogenic signaling pathways
- (2018) Claudia Fumarola et al. BIOCHEMICAL PHARMACOLOGY
- Extracellular vesicles and anti-Cancer drug resistance
- (2018) Niamh Mc Namee et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)
- (2018) Marthe-Susanna Wegner et al. BMC CANCER
- The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
- (2018) Milica Momcilovic et al. CANCER CELL
- NRF2 and the Hallmarks of Cancer
- (2018) Montserrat Rojo de la Vega et al. CANCER CELL
- Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism
- (2018) Ramachandran Rashmi et al. CANCER RESEARCH
- Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
- (2018) Tina Cascone et al. Cell Metabolism
- Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
- (2018) Hideki Iwamoto et al. Cell Metabolism
- JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance
- (2018) Tianyi Wang et al. Cell Metabolism
- LDHA in neuroblastoma is associated with poor outcome and its depletion decreases neuroblastoma growth independent of aerobic glycolysis
- (2018) Carmen Dorneburg et al. CLINICAL CANCER RESEARCH
- Metabolic vulnerability of cisplatin‐resistant cancers
- (2018) Florine Obrist et al. EMBO JOURNAL
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- (2018) Bettina von Neubeck et al. INTERNATIONAL JOURNAL OF CANCER
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- (2018) Tianxiao Gong et al. Journal of Translational Medicine
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- (2018) Courtney D DiNardo et al. LANCET ONCOLOGY
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- Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
- (2018) Alexia Karen Cotte et al. Nature Communications
- Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects
- (2018) Cyril Corbet et al. Nature Communications
- Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase
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- (2018) Cyril Corbet Frontiers in Pharmacology
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- (2018) Géraldine Gentric et al. Cell Metabolism
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- Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
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- Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers
- (2018) Susmita Mondal et al. INTERNATIONAL JOURNAL OF CANCER
- Carbonic anhydrase XII inhibitors overcome P-glycoprotein-mediated resistance to temozolomide in glioblastoma
- (2018) Iris C. Salaroglio et al. MOLECULAR CANCER THERAPEUTICS
- Histidine catabolism is a major determinant of methotrexate sensitivity
- (2018) Naama Kanarek et al. NATURE
- Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
- (2018) Andrew M. Intlekofer et al. NATURE
- Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism
- (2018) Martin Benej et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Deciphering the metabolic role of AMPK in cancer multi-drug resistance
- (2018) Wen Tan et al. SEMINARS IN CANCER BIOLOGY
- Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism
- (2018) Austin Yeon et al. Theranostics
- Activation of LXRɑ/β by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer
- (2018) Soochi Kim et al. BMC CANCER
- Modulating ROS to overcome multidrug resistance in cancer
- (2018) Qingbin Cui et al. DRUG RESISTANCE UPDATES
- Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma
- (2018) Lan B Hoang‐Minh et al. EMBO JOURNAL
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- The role of cellular reactive oxygen species in cancer chemotherapy
- (2018) Haotian Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Targeting glycometabolic reprogramming to restore the sensitivity of leukemia drug-resistant K562/ADM cells to adriamycin
- (2018) Xueyan Zhang et al. LIFE SCIENCES
- Spatially resolved metabolomics to discover tumor-associated metabolic alterations
- (2018) Chenglong Sun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer
- (2018) Giorgia Zadra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity
- (2018) Benny Zhitomirsky et al. Cell Death & Disease
- Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance
- (2018) Jayshree Hirpara et al. Redox Biology
- Chemoresistance: Intricate Interplay Between Breast Tumor Cells and Adipocytes in the Tumor Microenvironment
- (2018) Ilze Mentoor et al. Frontiers in Endocrinology
- Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes
- (2018) Mariantonia Logozzi et al. Cancers
- The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases
- (2018) Saima Kausar et al. Cells
- The Influence of Metabolism on Drug Response in Cancer
- (2018) Esther A. Zaal et al. Frontiers in Oncology
- PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC
- (2017) Mi-Jin Kim et al. MOLECULAR CANCER RESEARCH
- Calcium-Dependent Enhancement by Extracellular Acidity of the Cytotoxicity of Mitochondrial Inhibitors against Melanoma
- (2017) Fumihito Noguchi et al. MOLECULAR CANCER THERAPEUTICS
- Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non–Small Cell Lung Cancer Cells
- (2017) Kayleigh C. Ross et al. MOLECULAR CANCER THERAPEUTICS
- Glycometabolic adaptation mediates the insensitivity of drug-resistant K562/ADM leukaemia cells to adriamycin via the AKT-mTOR/c-Myc signalling pathway
- (2017) Xueyan Zhang et al. Molecular Medicine Reports
- Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
- (2017) Prasenjit Dey et al. NATURE
- Glucose feeds the TCA cycle via circulating lactate
- (2017) Sheng Hui et al. NATURE
- Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
- (2017) Vasanthi S. Viswanathan et al. NATURE
- Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells
- (2017) Elodie M Kuntz et al. NATURE MEDICINE
- Tumour heterogeneity and resistance to cancer therapies
- (2017) Ibiayi Dagogo-Jack et al. Nature Reviews Clinical Oncology
- The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer
- (2017) V Thewes et al. ONCOGENE
- Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
- (2017) Pasquale Sansone et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Therapeutic implications of tumor interstitial acidification
- (2017) Iryna Kolosenko et al. SEMINARS IN CANCER BIOLOGY
- The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells
- (2017) Joana Balça-Silva et al. Translational Oncology
- MICU1 drives glycolysis and chemoresistance in ovarian cancer
- (2017) Prabir K. Chakraborty et al. Nature Communications
- NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
- (2017) Karthigayan Shanmugasundaram et al. Nature Communications
- Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism
- (2017) Thomas Farge et al. Cancer Discovery
- Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells
- (2017) Ravyn M. Thompson et al. Oncotarget
- Mitochondrial “power” drives tamoxifen resistance: NQO1 and GCLC are new therapeutic targets in breast cancer
- (2017) Marco Fiorillo et al. Oncotarget
- Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer
- (2017) Medhi Wangpaichitr et al. Oncotarget
- 11C-Methionine-PET in Multiple Myeloma: A Combined Study from Two Different Institutions
- (2017) Constantin Lapa et al. Theranostics
- Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells
- (2017) F Pepe et al. Oncogenesis
- The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities
- (2017) Kate L. Hertweck et al. Frontiers in Oncology
- Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy
- (2016) R. Moschoi et al. BLOOD
- Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma
- (2016) Alina Filatova et al. CANCER RESEARCH
- The Role of Cholesterol in Cancer
- (2016) Omer F. Kuzu et al. CANCER RESEARCH
- Metabolic Heterogeneity in Human Lung Tumors
- (2016) Christopher T. Hensley et al. CELL
- Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer
- (2016) D S Matassa et al. CELL DEATH AND DIFFERENTIATION
- Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation
- (2016) Cyril Corbet et al. Cell Metabolism
- Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
- (2016) Shawn M. Davidson et al. Cell Metabolism
- Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche
- (2016) Haobin Ye et al. Cell Stem Cell
- Targeting AMPK Signaling Pathway to Overcome Drug Resistance for Cancer Therapy
- (2016) Zhiyu Wang et al. CURRENT DRUG TARGETS
- Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics
- (2016) Ruud H. Wijdeven et al. DRUG RESISTANCE UPDATES
- Lysosomes as mediators of drug resistance in cancer
- (2016) Benny Zhitomirsky et al. DRUG RESISTANCE UPDATES
- Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
- (2016) Wen Li et al. DRUG RESISTANCE UPDATES
- Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
- (2016) Gao Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway
- (2016) Jing Liu et al. Journal of Hematology & Oncology
- Evaluation of Prostate Cancer with 11C-Acetate PET/CT
- (2016) C. Spick et al. JOURNAL OF NUCLEAR MEDICINE
- Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes, in particular in redox and energy metabolism
- (2016) G P Soriano et al. LEUKEMIA
- FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model
- (2016) C. Gstalder et al. MOLECULAR CANCER THERAPEUTICS
- Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
- (2016) Cristovão M. Sousa et al. NATURE
- Tumour-specific proline vulnerability uncovered by differential ribosome codon reading
- (2016) Fabricio Loayza-Puch et al. NATURE
- Cancer metabolism: a therapeutic perspective
- (2016) Ubaldo E. Martinez-Outschoorn et al. Nature Reviews Clinical Oncology
- Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
- (2016) Andrew W. Roberts et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance
- (2016) T Yu et al. ONCOGENE
- Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
- (2016) Konstantinos J. Mavrakis et al. SCIENCE
- LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity
- (2016) Haifeng Wang et al. Oncology Letters
- Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
- (2016) C. Vernieri et al. Cancer Discovery
- Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells
- (2016) Paola Pellegrini et al. Oncotarget
- Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors
- (2016) Joanna Kopecka et al. Oncotarget
- MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer
- (2016) Leiming Wang et al. Oncotarget
- Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance
- (2016) Sofia Avnet et al. Oncotarget
- Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients
- (2016) Gabriela Jiménez-Valerio et al. Cell Reports
- Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling
- (2016) Elizabeth Allen et al. Cell Reports
- Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy
- (2016) Laura Pisarsky et al. Cell Reports
- ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer
- (2016) Sunghee Park et al. Cell Reports
- Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide
- (2016) Joseph E. Ippolito et al. PLoS One
- ABCB1, ABCC1, and LRP gene expressions are altered by LDL, HDL, and serum deprivation in a human doxorubicin-resistant uterine sarcoma cell line
- (2015) Andréa Turbuck Celestino et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cholesterol reduces the sensitivity to platinum-based chemotherapy via upregulating ABCG2 in lung adenocarcinoma
- (2015) Yufeng Wu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
- (2015) Khalid O Alfarouk et al. Cancer Cell International
- Application of Evolutionary Principles to Cancer Therapy
- (2015) P. M. Enriquez-Navas et al. CANCER RESEARCH
- An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
- (2015) Kıvanç Birsoy et al. CELL
- Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
- (2015) Ping-Chih Ho et al. CELL
- Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
- (2015) Chih-Hao Chang et al. CELL
- MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells
- (2015) Patricia Sancho et al. Cell Metabolism
- SIRT1/PGC1 -Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
- (2015) T. T. Vellinga et al. CLINICAL CANCER RESEARCH
- Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer
- (2015) V. De Rosa et al. CLINICAL CANCER RESEARCH
- Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach
- (2015) Sophie Taylor et al. DRUG RESISTANCE UPDATES
- Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism
- (2015) Helena Joyce et al. Expert Opinion on Drug Metabolism & Toxicology
- Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment
- (2015) Ganesh Venkatraman et al. FASEB JOURNAL
- Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
- (2015) Kazuhiro Tanaka et al. JOURNAL OF CLINICAL INVESTIGATION
- Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
- (2015) Katherine Sellers et al. JOURNAL OF CLINICAL INVESTIGATION
- Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
- (2015) Ibtissam Marchiq et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- The Role of C/EBP-β LIP in Multidrug Resistance
- (2015) Chiara Riganti et al. JNCI-Journal of the National Cancer Institute
- Vemurafenib resistance reprograms melanoma cells towards glutamine dependence
- (2015) Jenny E Hernandez-Davies et al. Journal of Translational Medicine
- Drug transporters play a key role in the complex process of Imatinib resistance in vitro
- (2015) Raquel Alves et al. LEUKEMIA RESEARCH
- Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells
- (2015) Franziska Baenke et al. Molecular Oncology
- Brain tumour cells interconnect to a functional and resistant network
- (2015) Matthias Osswald et al. NATURE
- Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
- (2015) Xiaofeng Zheng et al. NATURE
- Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
- (2015) Daniel Herranz et al. NATURE MEDICINE
- TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells
- (2015) F Lozupone et al. ONCOGENE
- Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
- (2015) Sriram Venneti et al. Science Translational Medicine
- Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles
- (2015) Diana Sousa et al. TRENDS IN MOLECULAR MEDICINE
- Establishment and characterization of a bladder cancer cell line with enhanced doxorubicin resistance by mevalonate pathway activation
- (2015) Annemarie Greife et al. TUMOR BIOLOGY
- Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
- (2015) Daniela Catanzaro et al. Oncotarget
- Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro
- (2015) Yali Zhong et al. Oncotarget
- Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells
- (2015) Joanna Kopecka et al. Oncotarget
- Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner
- (2015) Rikke B. Holmgaard et al. Cell Reports
- Signal Transduction in Cancer
- (2015) R. Sever et al. Cold Spring Harbor Perspectives in Medicine
- Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers
- (2015) James B. Stewart et al. PLoS Genetics
- The Role of C/EBP-β LIP in Multidrug Resistance
- (2015) Chiara Riganti et al. JNCI-Journal of the National Cancer Institute
- 2-Deoxy-d-Glucose Can Complement Doxorubicin and Sorafenib to Suppress the Growth of Papillary Thyroid Carcinoma Cells
- (2015) Shuo-Yu Wang et al. PLoS One
- Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance
- (2015) Benny Zhitomirsky et al. Oncotarget
- Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate
- (2014) Rakesh K. Pathak et al. ACS Chemical Biology
- The SIRT1/HIF2 Axis Drives Reductive Glutamine Metabolism under Chronic Acidosis and Alters Tumor Response to Therapy
- (2014) C. Corbet et al. CANCER RESEARCH
- Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
- (2014) Tomoyuki Mashimo et al. CELL
- Cisplatin in cancer therapy: Molecular mechanisms of action
- (2014) Shaloam Dasari et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth
- (2014) John C. Schell et al. MOLECULAR CELL
- Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
- (2014) Andrea Viale et al. NATURE
- Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin
- (2014) Cristina Federici et al. PLoS One
- Glucose-Regulated Protein 78 (Grp78) Confers Chemoresistance to Tumor Endothelial Cells under Acidic Stress
- (2014) Fernanda Visioli et al. PLoS One
- Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities
- (2014) María Cristina Estañ et al. PLoS One
- Bcl2L13 is a ceramide synthase inhibitor in glioblastoma
- (2014) S. A. Jensen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival
- (2014) Mireille Khacho et al. Nature Communications
- Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
- (2014) Young Seok Ju et al. eLife
- Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: Implication of reconstituted tumor microenvironment and multidrug resistance phenotype
- (2013) Shiva Kant et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
- (2013) C. D. DiNardo et al. BLOOD
- PDK1 inhibition is a novel therapeutic target in multiple myeloma
- (2013) S Fujiwara et al. BRITISH JOURNAL OF CANCER
- Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib
- (2013) W Y Sanchez et al. BRITISH JOURNAL OF CANCER
- PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
- (2013) Francisca Vazquez et al. CANCER CELL
- Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
- (2013) Rizwan Haq et al. CANCER CELL
- Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
- (2013) Luika A. Timmerman et al. CANCER CELL
- Targeting cisplatin-resistant human tumor cells with metabolic inhibitors
- (2013) Elizabeth J. Sullivan et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma
- (2013) M. Yoshikawa et al. CANCER RESEARCH
- BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
- (2013) Eleni D. Lagadinou et al. Cell Stem Cell
- Mitochondrial modulation decreases the bortezomib-resistance in multiple myeloma cells
- (2013) I.S. Song et al. INTERNATIONAL JOURNAL OF CANCER
- Therapy-induced enrichment of putative lung cancer stem-like cells
- (2013) Daniela P. Freitas et al. INTERNATIONAL JOURNAL OF CANCER
- Targeting lactate metabolism for cancer therapeutics
- (2013) Joanne R. Doherty et al. JOURNAL OF CLINICAL INVESTIGATION
- Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance
- (2013) Jennifer Pasquier et al. Journal of Translational Medicine
- Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition
- (2013) Giada Gelsomino et al. Molecular Cancer
- Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma
- (2013) P. Yuan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma
- (2012) Pilar Caro et al. CANCER CELL
- Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?
- (2012) Ralph J. DeBerardinis et al. CELL
- AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
- (2012) Brandon Faubert et al. Cell Metabolism
- Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance
- (2012) Nitzan Gonen et al. DRUG RESISTANCE UPDATES
- Mitochondrial DNA Mutation in Serous Ovarian Cancer: Implications for Mitochondria-Coded Genes in Chemoresistance
- (2012) Flora Guerra et al. JOURNAL OF CLINICAL ONCOLOGY
- A possible role for oxidation stress in lymphoid leukaemias and therapeutic failure
- (2012) Ana Bela Sarmento-Ribeiro et al. LEUKEMIA RESEARCH
- Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel
- (2012) Isabel R. Schlaepfer et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells
- (2012) Kakajan Komurov et al. Molecular Systems Biology
- Passenger deletions generate therapeutic vulnerabilities in cancer
- (2012) Florian L. Muller et al. NATURE
- Metabolism of [U-13C]glucose in human brain tumorsin vivo
- (2012) Elizabeth A. Maher et al. NMR IN BIOMEDICINE
- LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump
- (2012) S Fan et al. ONCOGENE
- BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery
- (2012) J Hagenbuchner et al. ONCOGENE
- Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity
- (2011) Manuela Polimeni et al. BIOCHEMICAL JOURNAL
- Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer
- (2011) Rachel A. Murphy et al. CANCER
- Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism
- (2011) Y. Zhao et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function
- (2011) D. G. Hardie GENES & DEVELOPMENT
- Acidic stress promotes a glioma stem cell phenotype
- (2010) A B Hjelmeland et al. CELL DEATH AND DIFFERENTIATION
- MicroRNA regulation of core apoptosis pathways in cancer
- (2010) Raquel T. Lima et al. EUROPEAN JOURNAL OF CANCER
- Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
- (2010) Rupal Ramakrishnan et al. JOURNAL OF CLINICAL INVESTIGATION
- A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells
- (2010) Joanna Kopecka et al. JOURNAL OF CONTROLLED RELEASE
- Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial
- (2009) P Bougnoux et al. BRITISH JOURNAL OF CANCER
- Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes
- (2009) K. Dietl et al. JOURNAL OF IMMUNOLOGY
- Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors
- (2009) Corina Kohler et al. Molecular Cancer
- Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)
- (2009) Teresa WM Fan et al. Molecular Cancer
- The xc− cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance
- (2008) M Lo et al. BRITISH JOURNAL OF CANCER
- Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1
- (2008) E. Furuta et al. CANCER RESEARCH
- Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1)in vitroandin vivoby increasing the activity of the p-glycoproteinviaactivation of p38
- (2008) Christoph Sauvant et al. INTERNATIONAL JOURNAL OF CANCER
- Induction of Pyruvate Dehydrogenase Kinase-3 by Hypoxia-inducible Factor-1 Promotes Metabolic Switch and Drug Resistance
- (2008) Chun-Wun Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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