Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Histidine catabolism is a major determinant of methotrexate sensitivity

(2018) Naama Kanarek et al.   NATURE

Metabolic interactions with cancer epigenetics

(2017) Xia Gao et al.   MOLECULAR ASPECTS OF MEDICINE

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

(2016) J. R. Hens et al.   BMC CANCER

Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

(2016) Xiaojing Liu et al.   Cell Metabolism

Targeting One Carbon Metabolism with an Antimetabolite Disrupts Pyrimidine Homeostasis and Induces Nucleotide Overflow

(2016) Zheng Ser et al.   Cell Reports

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet

(2015) Xiaojing Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy

(2015) Everett J. Moding et al.   Science Translational Medicine

Development and Quantitative Evaluation of a High-Resolution Metabolomics Technology

(2014) Xiaojing Liu et al.   ANALYTICAL CHEMISTRY

Serine Deprivation Enhances Antineoplastic Activity of Biguanides

(2014) S.-P. Gravel et al.   CANCER RESEARCH

Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium

(2014) Everett J. Moding et al.   JOURNAL OF CLINICAL INVESTIGATION

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice

(2013) Virginia L. Malloy et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice

(2012) C.-L. Lee et al.   Disease Models & Mechanisms

Characterization of an Oxaliplatin Sensitivity Predictor in a Preclinical Murine Model of Colorectal Cancer

(2012) M. K. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Histological and Molecular Evaluation of Patient-Derived Colorectal Cancer Explants

(2012) Joshua M. Uronis et al.   PLoS One

Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

(2012) Gene P. Ables et al.   PLoS One

Randomized, Phase III Trial of Panitumumab With Infusional Fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX4) Versus FOLFOX4 Alone As First-Line Treatment in Patients With Previously Untreated Metastatic Colorectal Cancer: The PRIME Study

(2010) Jean-Yves Douillard et al.   JOURNAL OF CLINICAL ONCOLOGY

Dietary Methionine Restriction with FOLFOX Regimen as First Line Therapy of Metastatic Colorectal Cancer: A Feasibility Study

(2010) Xavier Durando et al.   ONCOLOGY

Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study

(2008) Leonard B. Saltz et al.   JOURNAL OF CLINICAL ONCOLOGY

Kinetic flux profiling for quantitation of cellular metabolic fluxes

(2008) Jie Yuan et al.   Nature Protocols