Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment

A phase I–II study of plerixafor in combination with fludarabine, idarubicin, cytarabine, and G-CSF (PLERIFLAG regimen) for the treatment of patients with the first early-relapsed or refractory acute myeloid leukemia

(2018) David Martínez-Cuadrón et al.   ANNALS OF HEMATOLOGY

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

Enduring epigenetic landmarks define the cancer microenvironment

(2018) Ruth Pidsley et al.   GENOME RESEARCH

Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells

(2018) Pradeep Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin

(2018) Tracy Tabib et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

(2018) Christina Philippeos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

Targeting the tumour stroma to improve cancer therapy

(2018) Kenneth C. Valkenburg et al.   Nature Reviews Clinical Oncology

Lineage identity and location within the dermis determine the function of papillary and reticular fibroblasts in human skin

(2018) Ana Korosec et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

LOXL2, a copper-dependent monoamine oxidase, activates lung fibroblasts through the TGF-β/Smad pathway

(2018) Xiaohong Wen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators

(2018) Xinh-Xinh Nguyen et al.   Frontiers in Endocrinology

Blocking Autophagy in Cancer-Associated Fibroblasts Supports Chemotherapy of Pancreatic Cancer Cells

(2018) Xianbin Zhang et al.   Frontiers in Oncology

A Phase 1/1b tolerability study of rilotumumab alone or in combination with cisplatin and capecitabine in Japanese patients with gastric cancer

(2017) Toshihiko Doi et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin

(2017) Begum Erdogan et al.   JOURNAL OF CELL BIOLOGY

Cancer-associated fibroblasts lead tumor invasion through integrin-β3–dependent fibronectin assembly

(2017) Youmna Attieh et al.   JOURNAL OF CELL BIOLOGY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rilotumumab plus epirubicin, cisplatin, and capecitabine as first-line therapy in advanced MET-positive gastric or gastro-oesophageal junction cancer (RILOMET-1): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Daniel V T Catenacci et al.   LANCET ONCOLOGY

Revisiting Seed and Soil: Examining the Primary Tumor and Cancer Cell Foraging in Metastasis

(2017) Amber E. de Groot et al.   MOLECULAR CANCER RESEARCH

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

(2017) Huipeng Li et al.   NATURE GENETICS

A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second‐Line Treatment of MetastaticKRASMutant Colorectal Adenocarcinoma

(2017) J. Randolph Hecht et al.   ONCOLOGIST

A Phase II Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First‐Line Treatment of Pancreatic Adenocarcinoma

(2017) Al B. Benson et al.   ONCOLOGIST

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

(2017) David Lagares et al.   Science Translational Medicine

Tenascin-C induces migration and invasion through JNK/c-Jun signalling in pancreatic cancer

(2017) Jun Cai et al.   Oncotarget

Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer

(2017) Joan Chang et al.   Oncotarget

The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes

(2017) Maria Benito-Jardón et al.   eLife

Final results from a phase I study of TRC093 (humanized anti-cleaved collagen antibody) in patients with solid cancer.

(2017) F. Robert et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of Ovarian Tumor Growth by Targeting the HU177 Cryptic Collagen Epitope

(2016) Jennifer M. Caron et al.   AMERICAN JOURNAL OF PATHOLOGY

Lysyl oxidase expression in cardiac fibroblasts is regulated by α2β1 integrin interactions with the cellular microenvironment

(2016) Albert E. Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transforming growth factor β as regulator of cancer stemness and metastasis

(2016) Claudia Bellomo et al.   BRITISH JOURNAL OF CANCER

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

TGFβR1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of the Anti-GD2 Antibody Dinutuximab (ch14.18) with Natural Killer Cells

(2016) Hung C. Tran et al.   CLINICAL CANCER RESEARCH

Serum Level of Matrix Metalloproteinase-9 in Patients with Head and Neck Squamous Cell Carcinoma

(2016) Adina Stanciu et al.   Clinical Laboratory

Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma

(2016) Katarzyna Jakubowska et al.   DISEASE MARKERS

Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis

(2016) Fei Teng et al.   Journal of Hematology & Oncology

Matrix metalloproteinase-9 and -2 and tissue inhibitor of matrix metalloproteinase-2 in invasive pituitary adenomas

(2016) Hong-Yan Liu et al.   MEDICINE

Expression of metalloproteinases (MMP-2 and MMP-9) in basal-cell carcinoma

(2016) Anna Goździalska et al.   MOLECULAR BIOLOGY REPORTS

Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis

(2016) S L Ashley et al.   Mucosal Immunology

A tenascin C targeted nanoliposome with navitoclax for specifically eradicating of cancer-associated fibroblasts

(2016) Binlong Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma

(2016) Alba A. Brandes et al.   NEURO-ONCOLOGY

Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers

(2016) Lin-ting Hsia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Worse prognosis in breast cancer patients can be predicted by immunohistochemical analysis of positive MMP-2 and negative estrogen and progesterone receptors

(2016) Edneia A. S. Ramos et al.   Revista da Associacao Medica Brasileira

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

(2016) Onur Kanisicak et al.   Nature Communications

Prognostic impact of serum and tissue MMP-9 in non-small cell lung cancer: a systematic review and meta-analysis

(2016) Liang Gong et al.   Oncotarget

Emerging role of LOXL2 in the promotion of pancreas cancer metastasis

(2016) Joon Seong Park et al.   Oncotarget

MMP2 and MMP9 serum levels are associated with favorable outcome in patients with inflammatory breast cancer treated with bevacizumab-based neoadjuvant chemotherapy in the BEVERLY-2 study

(2016) Emeline Tabouret et al.   Oncotarget

Prognostic value of MMP9 activity level in resected stage I B lung adenocarcinoma

(2016) Yongfeng Yu et al.   Cancer Medicine

Comparison of MMP2 and MMP9 expression levels between primary and metastatic regions of oral squamous cell carcinoma

(2016) Kensuke Nishio et al.   Journal of Oral Science

Comparative Analysis of Matrix Metalloproteinase Family Members Reveals That MMP9 Predicts Survival and Response to Temozolomide in Patients with Primary Glioblastoma

(2016) Qingbin Li et al.   PLoS One

Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer

(2016) Maria Nilsson et al.   Scientific Reports

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression

(2015) Alexandra Fullár et al.   BMC CANCER

Intralesional administration of L19-IL2/L19-TNF in stage III or stage IVM1a melanoma patients: results of a phase II study

(2015) Riccardo Danielli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival

(2015) S. Torres et al.   CLINICAL CANCER RESEARCH

Tenascin-C: Its functions as an integrin ligand

(2015) Richard P. Tucker et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma

(2015) Shinya Neri et al.   INTERNATIONAL JOURNAL OF CANCER

The Expression of Tumor-Derived and Stromal-Derived Matrix Metalloproteinase 2 Predicted Prognosis of Ovarian Cancer

(2015) Ziyi Fu et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Prognostic effect of matrix metalloproteinase-9 in patients with resected Non small cell lung cancer

(2015) Chang Young Lee et al.   Journal of Cardiothoracic Surgery

Has the search for a marker of activated fibroblasts finally come to an end?

(2015) W. Matthijs Blankesteijn   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases

(2015) Andreia L Bates et al.   JOURNAL OF PATHOLOGY

Cancer-associated fibroblast-derived CXCL12 causes tumor progression in adenocarcinoma of the esophagogastric junction

(2015) Hidetaka Sugihara et al.   MEDICAL ONCOLOGY

Origin and Function of Myofibroblasts in the Liver

(2015) Robert Schwabe et al.   SEMINARS IN LIVER DISEASE

The tumor-targeting immunocytokine F16-IL2 in combination with doxorubicin: dose escalation in patients with advanced solid tumors and expansion into patients with metastatic breast cancer

(2015) Chiara Catania et al.   Cell Adhesion & Migration

Inhibition of Lysyl Oxidases Improves Drug Diffusion and Increases Efficacy of Cytotoxic Treatment in 3D Tumor Models

(2015) Friedrich Schütze et al.   Scientific Reports

Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth

(2015) Kazuyoshi Shiga et al.   Cancers

The Impact of Matrix Metalloproteinase 2 on Prognosis and Clinicopathology of Breast Cancer Patients: A Systematic Meta-Analysis

(2015) Yiping Chen et al.   PLoS One

Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer

(2015) Derek C. Marshall et al.   PLoS One

Association of Matrix Metalloproteinase (MMP)-2 and -9 Expression with Extra-gastrointestinal Stromal Tumor Metastasis

(2014) Chao Wang et al.   Asian Pacific Journal of Cancer Prevention

The MMP-2 -735 C Allele is a Risk Factor for Susceptibility to Breast Cancer

(2014) Kheirollah Yari et al.   Asian Pacific Journal of Cancer Prevention

MMP-9 expression varies according to molecular subtypes of breast cancer

(2014) Einas M Yousef et al.   BMC CANCER

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Lysyl oxidase-like 2 (LOXL2) from stromal fibroblasts stimulates the progression of gastric cancer

(2014) Hiroaki Kasashima et al.   CANCER LETTERS

Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

(2014) Thomas Moore-Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Human mesenchymal stem cells express a myofibroblastic phenotype in vitro: comparison to human cardiac myofibroblasts

(2014) Melanie A. Ngo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma

(2014) John C. Morris et al.   PLoS One

Expression and Clinical Significance of Matrix Metalloproteinase-9 in Lymphatic Invasiveness and Metastasis of Breast Cancer

(2014) Qiu-Wan Wu et al.   PLoS One

Serum levels and tissue expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinases 2 (TIMP-2) in colorectal cancer patients

(2014) Magdalena Groblewska et al.   TUMOR BIOLOGY

Cellular Sources of Tenascin-C in Canine Mammary Carcinomas

(2014) H. Yoshimura et al.   VETERINARY PATHOLOGY

Elevated expression levels of androgen receptors and matrix metalloproteinase-2 and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissues as predictors of cancer invasion and staging

(2014) YAN ZHANG et al.   Experimental and Therapeutic Medicine

Expression levels of matrix metalloproteinase-9 in human gastric carcinoma

(2014) SU-ZUAN CHEN et al.   Oncology Letters

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

(2013) Y Yu et al.   BRITISH JOURNAL OF CANCER

Hepatocyte growth factor activates tumor stromal fibroblasts to promote tumorigenesis in gastric cancer

(2013) Xiongyan Wu et al.   CANCER LETTERS

TGF-  Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment

(2013) T.-L. Yeung et al.   CANCER RESEARCH

Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor- -Deficient Mouse Mammary Carcinomas

(2013) M. W. Pickup et al.   CANCER RESEARCH

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Association of matrix metalloproteinase 2 plasma level with response and survival in patients treated with bevacizumab for recurrent high-grade glioma

(2013) Emeline Tabouret et al.   NEURO-ONCOLOGY

Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice

(2013) E Serres et al.   ONCOGENE

The history of matrix metalloproteinases: milestones, myths, and misperceptions

(2012) Rugmani Padmanabhan Iyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Prognostic Impact of Cancer-Associated Stromal Cells in Patients With Stage I Lung Adenocarcinoma

(2012) Masami Ito et al.   CHEST

What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis

(2012) Keiko Iwaisako et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Microenvironment and tumor progression of melanoma: New therapeutic prospectives

(2012) Gerardo Botti et al.   Journal of Immunotoxicology

Different Gene Expression Patterns in Human Papillary and Reticular Fibroblasts

(2012) David G. Janson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Transmembrane Collagen Receptors

(2011) Birgit Leitinger   Annual Review of Cell and Developmental Biology

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator

(2011) Florence Brellier et al.   FEBS LETTERS

Fibroblasts and Myofibroblasts: What Are We Talking About?

(2011) Jennifer Baum et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Breast Cancer Cells Induce Cancer-Associated Fibroblasts to Secrete Hepatocyte Growth Factor to Enhance Breast Tumorigenesis

(2011) Shiaw-Wei Tyan et al.   PLoS One

An overview of the c-MET signaling pathway

(2011) Shawna Leslie Organ et al.   Therapeutic Advances in Medical Oncology

Phase II AIDS Malignancy Consortium Trial of Topical Halofuginone in AIDS-Related Kaposi Sarcoma

(2010) Henry B Koon et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The Fibroblast Integrin α11β1 Is Induced in a Mechanosensitive Manner Involving Activin A and Regulates Myofibroblast Differentiation

(2010) Sergio Carracedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast

(2010) M Bauer et al.   ONCOGENE

Inhibition of Pancreatic Stellate Cell Activation by Halofuginone Prevents Pancreatic Xenograft Tumor Development

(2010) Itai Spector et al.   PANCREAS

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Cancer associated fibroblasts (CAFs) in tumor microenvironment

(2009) Fei Xing   Frontiers in Bioscience-Landmark

Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts

(2008) E. Ostermann et al.   CLINICAL CANCER RESEARCH

Formation and activation of fibroblast spheroids depend on fibronectin–integrin interaction

(2008) Pertteli Salmenperä et al.   EXPERIMENTAL CELL RESEARCH

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY