Glycolysis-induced drug resistance in tumors—A response to danger signals?

HOTAIRM1 knockdown enhances cytarabine-induced cytotoxicity by suppression of glycolysis through the Wnt/β-catenin/PFKP pathway in acute myeloid leukemia cells

(2020) Li Chen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

FGFRL1 affects chemoresistance of small‐cell lung cancer by modulating the PI3K/Akt pathway via ENO1

(2020) Rui Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis

(2020) Jiao Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

(2020) Xinyi Wang et al.   Molecular Oncology

Mechanical regulation of glycolysis via cytoskeleton architecture

(2020) Jin Suk Park et al.   NATURE

Context-Dependent Pharmacological Effects of Metformin on the Immune System

(2020) Fabrizio Marcucci et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Knockdown of FOXO6 Inhibits Glycolysis and Reduces Cell Resistance to Paclitaxel in HCC Cells via PI3K/Akt Signaling Pathway

(2020) Xixiang Yu et al.   OncoTargets and Therapy

Lactate dehydrogenase: a marker of diminished antitumor immunity

(2020) Sandra Van Wilpe et al.   OncoImmunology

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

(2020) Kulsoom Zahra et al.   Frontiers in Oncology

Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis

(2020) Wan-Chun Li et al.   Frontiers in Oncology

SALL4 promotes gastric cancer progression via hexokinase II mediated glycolysis

(2020) Meng Shao et al.   Cancer Cell International

ACTR confers to Sorafenib resistance in hepatocellular carcinoma via facilitating the Warburg effect

(2020) Luyuan Ma et al.   CANCER SCIENCE

HOTAIR/miR‐125 axis‐mediated Hexokinase 2 expression promotes chemoresistance in human glioblastoma

(2020) Jinnan Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MiR-138 Suppresses the PDK1 Expression to Decrease the Oxaliplatin Resistance of Colorectal Cancer

(2020) Yao Wang et al.   OncoTargets and Therapy

Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness

(2020) Yu-Chan Chang et al.   Cell Death & Disease

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

(2020) Qingjian Li et al.   Nature Communications

Glucose Metabolic Reprogramming of ER Breast Cancer in Acquired Resistance to the CDK4/6 Inhibitor Palbociclib+

(2020) Nicla Lorito et al.   Cells

hENT1 reverses chemoresistance by regulating glycolysis in pancreatic cancer

(2020) Yun Xi et al.   CANCER LETTERS

GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells

(2020) Ga-Bin Park et al.   CARCINOGENESIS

PKM2 inhibition may reverse therapeutic resistance to transarterial chemoembolization in hepatocellular carcinoma

(2020) Sean P. Martin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

(2020) Na Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Oxidative Phosphorylation Reverses Drug Resistance in Cancer Cells by Blocking Autophagy Recycling

(2020) Jae-Seon Lee et al.   Cells

Reactive Oxygen Species: Drivers of Physiological and Pathological Processes

(2020) Javier Checa et al.   Journal of Inflammation Research

Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma

(2019) Saeed Daneshmandi et al.   Cancers

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

(2019) Cornelia Kröger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinoma

(2019) Jing-Wei Zhou et al.   MOLECULAR MEDICINE

Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells

(2019) Yanzhu Lin et al.   Cancer Cell International

Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival

(2019) Nadiia Lypova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy

(2019) Qiang Cai et al.   Molecular Cancer

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

(2019) Liang Zhang et al.   Science Translational Medicine

B7-H3 promotes aerobic glycolysis and chemoresistance in colorectal cancer cells by regulating HK2

(2019) Tongguo Shi et al.   Cell Death & Disease

Lactate dehydrogenase A regulates autophagy and tamoxifen resistance in breast cancer

(2019) Chandan Kanta Das et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion

(2019) Hong-Jen Lee et al.   Nature Communications

Elevated Hexokinase II Expression Confers Acquired Resistance to 4-Hydroxytamoxifen in Breast Cancer Cells

(2019) Xiaochuan Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibiting the HPV16 oncogene-mediated glycolysis sensitizes human cervical carcinoma cells to 5-fluorouracil

(2019) Dan Ma et al.   OncoTargets and Therapy

Effect of pyruvate kinase M2-regulating aerobic glycolysis on chemotherapy resistance of estrogen receptor-positive breast cancer

(2018) Yuejun Qian et al.   ANTI-CANCER DRUGS

Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer

(2018) Teng Wang et al.   BMC CANCER

Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3

(2018) Yali Wang et al.   CANCER SCIENCE

ENO2 Promotes Cell Proliferation, Glycolysis, and Glucocorticoid-Resistance in Acute Lymphoblastic Leukemia

(2018) Cheng-cheng Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

FGFR4 Links Glucose Metabolism and Chemotherapy Resistance in Breast Cancer

(2018) Min Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of Pyruvate Dehydrogenase Kinase as a Therapeutic Strategy against Cancer

(2018) Swatishree Sradhanjali et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover

(2018) Brent E. Fitzwalter et al.   DEVELOPMENTAL CELL

Prolyl hydroxylase 2: a promising target to inhibit hypoxia-induced cellular metabolism in cancer cells

(2018) Lakhveer Singh et al.   DRUG DISCOVERY TODAY

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

(2018) Philippe Icard et al.   DRUG RESISTANCE UPDATES

The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model

(2018) Efthymia Papaevangelou et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular targeting of glutaminase sensitizes ovarian cancer cells to chemotherapy

(2018) Chioniso P. Masamha et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Suppression of oxidative phosphorylation confers resistance against bevacizumab in experimental glioma

(2018) Jule A. Eriksson et al.   JOURNAL OF NEUROCHEMISTRY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

(2018) Tingting Yang et al.   ONCOGENE

Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis

(2018) Guo-Xin Hou et al.   Cell Death & Disease

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

(2018) Fu-Long Li et al.   Nature Communications

Metabolic Reprogramming During Multidrug Resistance in Leukemias

(2018) Raphael Silveira Vidal et al.   Frontiers in Oncology

Metabolic Symbiosis and Immunomodulation: How Tumor Cell-Derived Lactate May Disturb Innate and Adaptive Immune Responses

(2018) Alexandre Morrot et al.   Frontiers in Oncology

PTBP1 knockdown overcomes the resistance to vincristine and oxaliplatin in drug-resistant colon cancer cells through regulation of glycolysis

(2018) Chuanyao Cheng et al.   BIOMEDICINE & PHARMACOTHERAPY

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

(2018) Maria Apicella et al.   Cell Metabolism

New strategies for targeting glucose metabolism-mediated acidosis for colorectal cancer therapy

(2018) Gang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

(2018) Nina M. S. Gustafsson et al.   Nature Communications

LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

(2018) Mengyu Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting glycometabolic reprogramming to restore the sensitivity of leukemia drug-resistant K562/ADM cells to adriamycin

(2018) Xueyan Zhang et al.   LIFE SCIENCES

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

(2018) Anushka Dongre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype

(2018) Su Yeon Lee et al.   Oxidative Medicine and Cellular Longevity

The Influence of Metabolism on Drug Response in Cancer

(2018) Esther A. Zaal et al.   Frontiers in Oncology

Overexpression of HIF-1a could partially protect K562 cells from 1,4-benzoquinone induced toxicity by inhibiting ROS, apoptosis and enhancing glycolysis

(2018) Rongli Sun et al.   TOXICOLOGY IN VITRO

Tyrosine kinase inhibitor imatinib modulates the viability and apoptosis of castrate-resistant prostate cancer cells dependently on the glycolytic environment

(2018) Henrique J. Cardoso et al.   LIFE SCIENCES

Alpha-enolase promotes gastric cancer cell proliferation and metastasis via regulating AKT signaling pathway

(2018) Liang Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Development of GLUT4-selective antagonists for multiple myeloma therapy

(2017) Changyong Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma

(2017) Sainan Li et al.   INTERNATIONAL JOURNAL OF CANCER

Metformin increases sensitivity of osteosarcoma stem cells to cisplatin by inhibiting expression of PKM2

(2017) Depeng Shang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Effects of shRNA-Mediated Silencing of PKM2 Gene on Aerobic Glycolysis, Cell Migration, Cell Invasion, and Apoptosis in Colorectal Cancer Cells

(2017) Xiao-Ling Yan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells

(2017) Giulia Cesi et al.   Molecular Cancer

The role of autophagy in the cross-talk between epithelial-mesenchymal transitioned tumor cells and cancer stem-like cells

(2017) Fabrizio Marcucci et al.   Molecular Cancer

SALL4 promotes glycolysis and chromatin remodeling via modulating HP1α-Glut1 pathway

(2017) J Kim et al.   ONCOGENE

MiR-449a Suppresses LDHA-Mediated Glycolysis to Enhance the Sensitivity of Non-Small Cell Lung Cancer Cells to Ionizing Radiation

(2017) Liang Li et al.   ONCOLOGY RESEARCH

Loss of fructose-1,6-bisphosphatase induces glycolysis and promotes apoptosis resistance of cancer stem-like cells: an important role in hexavalent chromium-induced carcinogenesis

(2017) Jin Dai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MICU1 drives glycolysis and chemoresistance in ovarian cancer

(2017) Prabir K. Chakraborty et al.   Nature Communications

Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer

(2017) Medhi Wangpaichitr et al.   Oncotarget

Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer

(2017) Xiaoling Qian et al.   Oncotarget

Knockdown of PKM2 and GLS1 expression can significantly reverse oxaliplatin-resistance in colorectal cancer cells

(2017) Wei-Qun Lu et al.   Oncotarget

Metformin Inhibits Gemcitabine Induced Apoptosis in Pancreatic Cancer Cell Lines

(2017) Dietmar Zechner et al.   Journal of Cancer

Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin

(2017) Xing Wang et al.   Scientific Reports

Distinct cytoprotective roles of pyruvate and ATP by glucose metabolism on epithelial necroptosis and crypt proliferation in ischaemic gut

(2016) Ching-Ying Huang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors

(2016) Seraina Faes et al.   Molecular Cancer

Overcoming cetuximab resistance in Ewing's sarcoma by inhibiting lactate dehydrogenase-A

(2016) JIAXIN FU et al.   Molecular Medicine Reports

Epithelial–mesenchymal transition: a new target in anticancer drug discovery

(2016) Fabrizio Marcucci et al.   NATURE REVIEWS DRUG DISCOVERY

Non-metabolic functions of glycolytic enzymes in tumorigenesis

(2016) X Yu et al.   ONCOGENE

Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance

(2016) T Yu et al.   ONCOGENE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Resistance to chemotherapy is associated with altered glucose metabolism in acute myeloid leukemia

(2016) KUI SONG et al.   Oncology Letters

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

(2016) Min Xie et al.   Nature Communications

Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation

(2016) Yue Jin et al.   Oncotarget

Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling

(2016) Elizabeth Allen et al.   Cell Reports

Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells

(2015) Anant Narayan Bhatt et al.   BMC CANCER

Metabolic Signature Identifies Novel Targets for Drug Resistance in Multiple Myeloma

(2015) P. Maiso et al.   CANCER RESEARCH

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation

(2015) Waldemar Wagner et al.   Cell Communication and Signaling

Linking Cancer Metabolism to DNA Repair and Accelerated Senescence

(2015) E. V. Efimova et al.   MOLECULAR CANCER RESEARCH

Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells

(2015) Franziska Baenke et al.   Molecular Oncology

Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90–EGFR association

(2015) Y-C Yang et al.   ONCOGENE

Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis

(2015) J Zhang et al.   ONCOGENE

Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells

(2015) Wenjie Qin et al.   Oncotarget

Mitochondrial oxidative stress is the achille’s heel of melanoma cells resistant to Braf-mutant inhibitor

(2015) Paola Corazao-Rozas et al.   Oncotarget

Long-term In Vitro Treatment of Human Glioblastoma Cells with Temozolomide Increases Resistance In Vivo through Up-regulation of GLUT Transporter and Aldo-Keto Reductase Enzyme AKR1C Expression

(2015) Benjamin Le Calvé et al.   NEOPLASIA

Overexpression of MicroRNA-122 Re-sensitizes 5-FU-Resistant Colon Cancer Cells to 5-FU Through the Inhibition of PKM2 In Vitro and In Vivo

(2014) Jinxia He et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

(2014) T. Z. Tan et al.   EMBO Molecular Medicine

Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil

(2014) XIANGYONG LI et al.   Molecular Medicine Reports

Overexpression of microRNA-125b sensitizes human hepatocellular carcinoma cells to 5-fluorouracil through inhibition of glycolysis by targeting hexokinase II

(2014) JIAN-XIN JIANG et al.   Molecular Medicine Reports

Targeting glucose metabolism in chondrosarcoma cells enhances the sensitivity to doxorubicin through the inhibition of lactate dehydrogenase-A

(2014) GUOJUN HUA et al.   ONCOLOGY REPORTS

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

(2013) Elizabeth J. Sullivan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism

(2013) Yi Xuan et al.   EXPERIMENTAL CELL RESEARCH

Pushing tumor cells towards a malignant phenotype: Stimuli from the microenvironment, intercellular communications and alternative roads

(2013) Fabrizio Marcucci et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer cell bioenergetics and pH regulation influence breast cancer cell resistance to paclitaxel and doxorubicin

(2013) Diana Tavares-Valente et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

(2013) Kristiina Rajamäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cetuximab Reverses the Warburg Effect by Inhibiting HIF-1-Regulated LDH-A

(2013) H. Lu et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level

(2012) Oh-Hyung Kwon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

(2012) Y-C Shen et al.   BRITISH JOURNAL OF CANCER

Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target

(2012) HOON HUR et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metabolic symbiosis in cancer: Refocusing the Warburg lens

(2012) Erica C. Nakajima et al.   MOLECULAR CARCINOGENESIS

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

(2011) Y. Zhou et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Glycolysis inhibition targets Mcl-1 to restore sensitivity of lymphoma cells to ABT-737-induced apoptosis

(2011) O Meynet et al.   LEUKEMIA

Glycolysis Inhibition Inactivates ABC Transporters to Restore Drug Sensitivity in Malignant Cells

(2011) Ayako Nakano et al.   PLoS One

Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells

(2009) Jelena Klawitter et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The anti-oxidant capacity of tumour glycolysis

(2009) Ulrike G. A. Sattler et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab

(2009) Alejandro Vazquez-Martin et al.   PLoS One

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells

(2008) E. Hulleman et al.   BLOOD

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

(2008) A. Apel et al.   CANCER RESEARCH

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE