Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

The RB–IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity

(2017) S Kitajima et al.   ONCOGENE

Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology

(2016) Laura M. Desrochers et al.   DEVELOPMENTAL CELL

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Indication of Horizontal DNA Gene Transfer by Extracellular Vesicles

(2016) Stefanie Fischer et al.   PLoS One

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

(2016) Megan V. Jackson et al.   STEM CELLS

Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer

(2016) Pasquale Sansone et al.   Nature Communications

Mitochondrial DNA content in breast cancer: Impact on in vitro and in vivo phenotype and patient prognosis

(2016) Marjolein J.A. Weerts et al.   Oncotarget

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Mitochondrial dynamics regulating chemoresistance in gynecological cancers

(2015) Bao Kong et al.   Annals of the New York Academy of Sciences

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

A multi-parametric workflow for the prioritization of mitochondrial DNA variants of clinical interest

(2015) Mariangela Santorsola et al.   HUMAN GENETICS

Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

(2015) Jagadish C. Ghosh et al.   JNCI-Journal of the National Cancer Institute

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Challenges in the management of advanced, ER-positive, HER2-negative breast cancer

(2015) Christopher D. Hart et al.   Nature Reviews Clinical Oncology

Precision medicine for metastatic breast cancer—limitations and solutions

(2015) Monica Arnedos et al.   Nature Reviews Clinical Oncology

Evaluation of targeted therapies in advanced breast cancer: the need for large-scale molecular screening and transformative clinical trial designs

(2015) Z Fadoukhair et al.   ONCOGENE

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

(2015) Bruno M. Simões et al.   Cell Reports

Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy

(2015) Jagadish C. Ghosh et al.   JNCI-Journal of the National Cancer Institute

Metabolic Plasticity of Metastatic Breast Cancer Cells: Adaptation to Changes in the Microenvironment

(2015) Rui V. Simões et al.   NEOPLASIA

Cancer Metabolism: New Validated Targets for Drug Discovery

(2015) Federica Sotgia et al.   Oncotarget

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAB26 coordinates lysosome traffic and mitochondrial localization

(2014) R. U. Jin et al.   JOURNAL OF CELL SCIENCE

Mitochondrial changes in endometrial carcinoma: Possible role in tumor diagnosis and prognosis (Review)

(2014) ANTONELLA CORMIO et al.   ONCOLOGY REPORTS

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Myosin VIII associates with microtubule ends and together with actin plays a role in guiding plant cell division

(2014) Shu-Zon Wu et al.   eLife

Tamoxifen selects for breast cancer cells with mammosphere forming capacity and increased growth rate

(2013) Diego Raffo et al.   BREAST CANCER RESEARCH AND TREATMENT

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Luminal breast cancer: from biology to treatment

(2013) Michail Ignatiadis et al.   Nature Reviews Clinical Oncology

Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

(2013) Jin Cai et al.   Journal of Molecular Cell Biology

Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas

(2012) I. Kurelac et al.   HUMAN MOLECULAR GENETICS

Mitochondrial DNA Mutation in Serous Ovarian Cancer: Implications for Mitochondria-Coded Genes in Chemoresistance

(2012) Flora Guerra et al.   JOURNAL OF CLINICAL ONCOLOGY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Mitochondrial Biogenesis Drives Tumor Cell Proliferation

(2011) Ubaldo E. Martinez-Outschoorn et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

A Mutation Threshold Distinguishes the Antitumorigenic Effects of the Mitochondrial Gene MTND1, an Oncojanus Function

(2011) G. Gasparre et al.   CANCER RESEARCH

Mitochondrial metabolism and cancer

(2011) Ivana Kurelac et al.   MITOCHONDRION

HmtDB, a genomic resource for mitochondrion-based human variability studies

(2011) Francesco Rubino et al.   NUCLEIC ACIDS RESEARCH

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

(2011) C. Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial DNA Content as a Potential Marker to Predict Response to Anthracycline in Breast Cancer Patients

(2010) Chih-Wei Hsu et al.   Breast Journal

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

(2010) M. Guescini et al.   EXPERIMENTAL CELL RESEARCH

Alterations in bioenergetics due to changes in mitochondrial DNA copy number

(2010) Wei Qian et al.   METHODS