An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor
Authors
Keywords
-
Journal
Cancers
Volume 13, Issue 11, Pages 2813
Publisher
MDPI AG
Online
2021-06-04
DOI
10.3390/cancers13112813
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- (2021) Marek Samec et al. Cancers
- Dual Targeting Oncoproteins MYC and HIF1α Regresses Tumor Growth of Lung Cancer and Lymphoma
- (2021) Xiaohu Huang et al. Cancers
- Enhanced anti‐angiogenic activity of novel melatonin‐like agents
- (2021) Su Jung Hwang et al. JOURNAL OF PINEAL RESEARCH
- A comprehensive review on time-tested anticancer drug doxorubicin
- (2021) Sruthi Sritharan et al. LIFE SCIENCES
- Design, Synthesis, and Conformation–Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent Hypoxia Inducible Factor-1 Inhibitors and Antitumor Agents
- (2020) Kota Koike et al. JOURNAL OF MEDICINAL CHEMISTRY
- Liposomal formulation of HIF-1α inhibitor echinomycin eliminates established metastases of triple-negative breast cancer
- (2020) Christopher M. Bailey et al. Nanomedicine-Nanotechnology Biology and Medicine
- Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2
- (2020) Anindya Dey et al. Science Advances
- Repurposing of Acriflavine to target Chronic Myeloid Leukemia treatment
- (2020) Rawan Nehme et al. CURRENT MEDICINAL CHEMISTRY
- Melatonin as a potential inhibitor of kidney cancer: A survey of the molecular processes
- (2020) Parisa Maleki Dana et al. IUBMB LIFE
- Metformin ameliorates brain damage caused by cardiopulmonary resuscitation via targeting endoplasmic reticulum stress-related proteins GRP78 and XBP1
- (2020) Libo Chuan et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
- (2019) Tian Tian et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hypoxia and aging
- (2019) Eui-Ju Yeo EXPERIMENTAL AND MOLECULAR MEDICINE
- Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?
- (2019) Alice Bradbury et al. PHARMACOLOGY & THERAPEUTICS
- Apigenin: A dietary flavonoid with diverse anticancer properties
- (2018) Josip Madunić et al. CANCER LETTERS
- Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge
- (2018) Sho Koyasu et al. CANCER SCIENCE
- Final results of a randomized multicenter phase II study of alvocidib, cytarabine, and mitoxantrone versus cytarabine and daunorubicin (7 + 3) in newly diagnosed high-risk acute myeloid leukemia (AML)
- (2018) Joshua F. Zeidner et al. LEUKEMIA RESEARCH
- PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a multi-center, randomized double-blind, placebo-controlled phase 3 trial
- (2018) Sarah Kitson et al. CLINICAL CANCER RESEARCH
- Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2017) José Baselga et al. LANCET ONCOLOGY
- Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha
- (2017) Chao Zhang et al. Oncotarget
- Efficacy of the nanoparticle–drug conjugate CRLX101 in combination with bevacizumab in metastatic renal cell carcinoma: results of an investigator-initiated phase I–IIa clinical trial
- (2016) S. M. Keefe et al. ANNALS OF ONCOLOGY
- Melatonin Regulates Angiogenic Factors under Hypoxia in Breast Cancer Cell Lines
- (2016) Bruna Victorasso Jardim-Perassi et al. Anti-Cancer Agents in Medicinal Chemistry
- Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle-Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer
- (2016) E. Pham et al. CANCER RESEARCH
- Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions
- (2016) Stephen P. Burr et al. Cell Metabolism
- Class I and IIa HDACs Mediate HIF-1α Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1α Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc
- (2016) Zachary R Schoepflin et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization
- (2016) Mingbing Zeng et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance
- (2016) Hiroshi Harada JOURNAL OF RADIATION RESEARCH
- Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
- (2016) Caroline Wigerup et al. PHARMACOLOGY & THERAPEUTICS
- Preclinical testing of an ATR inhibitor demonstrates improved response to standard therapies for esophageal cancer
- (2016) Katarzyna B. Leszczynska et al. RADIOTHERAPY AND ONCOLOGY
- LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis
- (2016) Chan Joo Yeom et al. Oncotarget
- ATM and ATR as therapeutic targets in cancer
- (2015) Anika Maria Weber et al. PHARMACOLOGY & THERAPEUTICS
- Epidermal Growth Factor Receptor Inhibition Reduces Angiogenesis via Hypoxia-Inducible Factor-1α and Notch1 in Head Neck Squamous Cell Carcinoma
- (2015) Wei-Ming Wang et al. PLoS One
- H 2 S: A Novel Gasotransmitter that Signals by Sulfhydration
- (2015) Bindu D. Paul et al. TRENDS IN BIOCHEMICAL SCIENCES
- UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α
- (2015) Yoko Goto et al. Nature Communications
- Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma
- (2015) Xinke Zhou et al. Oncotarget
- Targeting hypoxia-inducible factor-1α (HIF-1α) in combination with antiangiogenic therapy: A phase I trial of bortezomib plus bevacizumab
- (2015) Gerald S. Falchook et al. Oncotarget
- Translational Impact of Nanoparticle-Drug Conjugate CRLX101 with or without Bevacizumab in Advanced Ovarian Cancer
- (2014) E. Pham et al. CLINICAL CANCER RESEARCH
- IFN- Induces Transcription of Hypoxia-Inducible Factor-1 to Inhibit Proliferation of Human Endothelial Cells
- (2014) S. A. Gerber et al. JOURNAL OF IMMUNOLOGY
- The Histone Deacetylase Inhibitor, Vorinostat, Represses Hypoxia Inducible Factor 1 Alpha Expression through Translational Inhibition
- (2014) Darren M. Hutt et al. PLoS One
- Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1
- (2014) B. Faubert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
- (2014) William W Wheaton et al. eLife
- Erratum to: Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1α and STAT-3
- (2013) Ganji Purnachandra Nagaraju et al. ANGIOGENESIS
- Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors
- (2013) Woondong Jeong et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Cellular and molecular mechanisms in the hypoxic tissue: role of HIF-1 and ROS
- (2013) Andrea B. Zepeda et al. CELL BIOCHEMISTRY AND FUNCTION
- A Multicenter Phase II Study of Ganetespib Monotherapy in Patients with Genotypically Defined Advanced Non-Small Cell Lung Cancer
- (2013) M. A. Socinski et al. CLINICAL CANCER RESEARCH
- Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer
- (2013) Lisha Xiang et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Phase I study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023
- (2012) Bojana Milojkovic Kerklaan et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- The anti-EGFR antibody cetuximab sensitizes human head and neck squamous cell carcinoma cells to radiation in part through inhibiting radiation-induced upregulation of HIF-1α
- (2012) Haiquan Lu et al. CANCER LETTERS
- Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors
- (2012) Chan Yeom et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Aryl hydrocarbon receptor activation by aminoflavone: New molecular target for renal cancer treatment
- (2012) Andrea Loaiza-Perez INTERNATIONAL JOURNAL OF ONCOLOGY
- Anthracycline Inhibits Recruitment of Hypoxia-inducible Transcription Factors and Suppresses Tumor Cell Migration and Cardiac Angiogenic Response in the Host
- (2012) Tetsuhiro Tanaka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Recent agents targeting HIF-1α for cancer therapy
- (2012) Yaozhong Hu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model
- (2012) Kil-Jung Kim et al. JOURNAL OF PINEAL RESEARCH
- Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
- (2012) Peppi Koivunen et al. NATURE
- ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression
- (2012) F Fallone et al. ONCOGENE
- Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro
- (2012) Zuo-Lin Wang ONCOLOGY REPORTS
- Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels
- (2012) Hiroshi Harada et al. Nature Communications
- Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects
- (2011) Puja Sapra et al. ANGIOGENESIS
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- Microtubule disruption targets HIF-1α mRNA to cytoplasmic P-bodies for translational repression
- (2011) Marisa Carbonaro et al. JOURNAL OF CELL BIOLOGY
- Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
- (2011) Christina D. Befani et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas
- (2011) Deviney Chaponis et al. JOURNAL OF NEURO-ONCOLOGY
- Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells
- (2011) Sung-Yun Cho et al. JOURNAL OF PINEAL RESEARCH
- Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90
- (2011) Ming Zhao et al. Molecular Cancer
- Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy
- (2011) W. Ying et al. MOLECULAR CANCER THERAPEUTICS
- The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo
- (2011) Zheng Wei Lee et al. PLoS One
- LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1α via upregulation of VHL in a colon cancer cell line
- (2010) Kyeong Lee et al. BIOCHEMICAL PHARMACOLOGY
- Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1 Expression in an AhR-Independent Fashion
- (2010) E. Terzuoli et al. CANCER RESEARCH
- Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization
- (2010) Tsunehiko Yoshida et al. FASEB JOURNAL
- Apigenin Down-Regulates the Hypoxia Response Genes: HIF-1α, GLUT-1, and VEGF in Human Pancreatic Cancer Cells
- (2010) Laleh G. Melstrom et al. JOURNAL OF SURGICAL RESEARCH
- Inhibition of Hypoxia-Inducible Factor-1α (HIF-1α) Protein Synthesis by DNA Damage Inducing Agents
- (2010) Jessica Jie Wei Lou et al. PLoS One
- Development of vorinostat: Current applications and future perspectives for cancer therapy
- (2009) Victoria M. Richon et al. CANCER LETTERS
- Identification of a Novel Small Molecule HIF-1 Translation Inhibitor
- (2009) T. Narita et al. CLINICAL CANCER RESEARCH
- Activity of 2 methoxyestradiol (Panzem ® NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: A Hoosier Oncology Group trial
- (2009) Daniela Matei et al. GYNECOLOGIC ONCOLOGY
- Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway
- (2009) Nobuko Koshikawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Cooperative Induction of Hypoxia-Inducible Factor-1 and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis
- (2009) M. Z. Noman et al. JOURNAL OF IMMUNOLOGY
- Melatonin down-regulates HIF-1α expression through inhibition of protein translation in prostate cancer cells
- (2009) Jong-Wook Park et al. JOURNAL OF PINEAL RESEARCH
- Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition
- (2009) A. Rapisarda et al. MOLECULAR CANCER THERAPEUTICS
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
- (2009) D. B. Shackelford et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
- (2009) K. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1
- (2008) D. H. Shin et al. BLOOD
- Imaging of the hypoxia-inducible factor pathway: insights into oxygen sensing
- (2008) U. Berchner-Pfannschmidt et al. EUROPEAN RESPIRATORY JOURNAL
- The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors
- (2008) Hiroshi Harada et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1
- (2008) M. Y. Koh et al. MOLECULAR CANCER THERAPEUTICS
- A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth
- (2008) L. M. Greenberger et al. MOLECULAR CANCER THERAPEUTICS
- Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198
- (2008) Theresa M. LaVallee et al. MOLECULAR CANCER THERAPEUTICS
- Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1 and -2
- (2008) M. Puppo et al. MOLECULAR CANCER THERAPEUTICS
- NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
- (2008) Jordi Rius et al. NATURE
- Digoxin and other cardiac glycosides inhibit HIF-1 synthesis and block tumor growth
- (2008) H. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Advanced oxidation processes: mechanistic aspects
- (2008) C. von Sonntag WATER SCIENCE AND TECHNOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started