Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Apoptotic Efficacy of Etomoxir in Human Acute Myeloid Leukemia Cells. Cooperation with Arsenic Trioxide and Glycolytic Inhibitors, and Regulation by Oxidative Stress and Protein Kinase Activities
Authors
Keywords
Apoptosis, HL60 cells, Fatty acids, Oxidative stress, Flow cytometry, Mitochondria, Oxidation, Protein kinases
Journal
PLoS One
Volume 9, Issue 12, Pages e115250
Publisher
Public Library of Science (PLoS)
Online
2014-12-16
DOI
10.1371/journal.pone.0115250
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The evolving use of arsenic in pharmacotherapy of malignant disease
- (2013) Athena Kritharis et al. ANNALS OF HEMATOLOGY
- Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy
- (2013) Haibin Xi et al. BIOCHEMICAL PHARMACOLOGY
- Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells
- (2013) S Scotland et al. LEUKEMIA
- Growth of xenotransplanted leukemia cells is influenced by diet nutrients and is attenuated with 2-deoxyglucose
- (2013) Norikazu Tsunekawa-Imai et al. LEUKEMIA RESEARCH
- Inhibition of Lipolysis by Mercaptoacetate and Etomoxir Specifically Sensitize Drug-Resistant Lung Adenocarcinoma Cell to Paclitaxel
- (2013) Jiajin Li et al. PLoS One
- Targeting cellular metabolism to improve cancer therapeutics
- (2013) Y Zhao et al. Cell Death & Disease
- 2-Deoxy-d-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: Involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways
- (2012) María Cristina Estañ et al. BIOCHEMICAL PHARMACOLOGY
- Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent disease
- (2012) Massimo Breccia et al. EXPERT OPINION ON PHARMACOTHERAPY
- A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
- (2012) Y. H. Ko et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Inhibition of Fatty Acid Metabolism Reduces Human Myeloma Cells Proliferation
- (2012) José Manuel Tirado-Vélez et al. PLoS One
- Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation
- (2011) Eva Calviño et al. BIOCHEMICAL PHARMACOLOGY
- AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia
- (2011) J. N. Kuznetsov et al. MOLECULAR CANCER THERAPEUTICS
- Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
- (2010) Lisa S. Pike et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Curcumin Stimulates Reactive Oxygen Species Production and Potentiates Apoptosis Induction by the Antitumor Drugs Arsenic Trioxide and Lonidamine in Human Myeloid Leukemia Cell Lines
- (2010) Y. Sanchez et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Energy metabolism of leukemia cells: glycolysisversusoxidative phosphorylation
- (2010) Kazuto Suganuma et al. LEUKEMIA & LYMPHOMA
- Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio
- (2009) Brooke M. Emerling et al. FREE RADICAL BIOLOGY AND MEDICINE
- Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy
- (2009) BS Dwarakanath et al. Future Oncology
- Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
- (2009) Ismael Samudio et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor Cell Metabolism: Cancer's Achilles' Heel
- (2008) Guido Kroemer et al. CANCER CELL
- Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir
- (2008) Emma Hernlund et al. INTERNATIONAL JOURNAL OF CANCER
- Genistein selectively potentiates arsenic trioxide‐induced apoptosis in human leukemia cellsviareactive oxygen species generation and activation of reactive oxygen species‐inducible protein kinases (p38‐MAPK, AMPK)
- (2008) Yolanda Sánchez et al. INTERNATIONAL JOURNAL OF CANCER
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now