Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling

Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer

(2020) Chenlei Zheng et al.   ONCOLOGY REPORTS

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

(2019) Sarbajeet Nagdas et al.   Cell Reports

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Demethylzeylasteral (ZST93) inhibits cell growth and enhances cell chemosensitivity to gemcitabine in human pancreatic cancer cells via apoptotic and autophagic pathways

(2018) Feng Wang et al.   INTERNATIONAL JOURNAL OF CANCER

mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy

(2018) Seung Un Seo et al.   ONCOGENE

Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G2 /M Arrest

(2017) Tao Peng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

PI3K-AKT-mTOR inhibitors in breast cancers: From tumor cell signaling to clinical trials

(2017) Nandini Dey et al.   PHARMACOLOGY & THERAPEUTICS

Sulforaphane as an adjunctive to everolimus counteracts everolimus resistance in renal cancer cell lines

(2017) Eva Juengel et al.   PHYTOMEDICINE

Capilliposide C Sensitizes Esophageal Squamous Carcinoma Cells to Oxaliplatin by Inducing Apoptosis Through the PI3K/Akt/mTOR Pathway

(2017) Zhipeng Shen et al.   MEDICAL SCIENCE MONITOR

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand

(2017) Tamir Epstein et al.   PLoS One

4E-BP1, a multifactor regulated multifunctional protein

(2016) Xiaoyu Qin et al.   CELL CYCLE

PI3K inhibitor LY294002, as opposed to wortmannin, enhances AKT phosphorylation in gemcitabine-resistant pancreatic cancer cells

(2016) Yufeng Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling

(2016) Lili Guo et al.   TUMOR BIOLOGY

Phosphoinositide 3-kinase-related overgrowth: cellular phenotype and future therapeutic options

(2015) Victoria E R Parker et al.   LANCET

The S6K protein family in health and disease

(2015) Mariana R. Tavares et al.   LIFE SCIENCES

Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype

(2015) Jiujie Cui et al.   MEDICAL ONCOLOGY

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

Inhibiting GLUT-1 expression and PI3K/Akt signaling using apigenin improves the radiosensitivity of laryngeal carcinoma in vivo

(2015) YANG-YANG BAO et al.   ONCOLOGY REPORTS

Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype

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Adjuvant Chemotherapy With Gemcitabine and Long-term Outcomes Among Patients With Resected Pancreatic Cancer

(2013) Helmut Oettle et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of Glucose Transporter 1 (GLUT1) Chemosensitized Head and Neck Cancer Cells to Cisplatin

(2013) Yao-Dong Wang et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells

(2012) Shingo Kagawa et al.   JOURNAL OF SURGICAL RESEARCH

Overcoming Trastuzumab Resistance in Breast Cancer by Targeting Dysregulated Glucose Metabolism

(2011) Y. Zhao et al.   CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Molecular predictors of gemcitabine response in pancreatic cancer

(2011) Ioannis A Voutsadakis   World Journal of Gastrointestinal Oncology

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms regulating cytochrome c release in pancreatic mitochondria

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