Molecular targeting of glutaminase sensitizes ovarian cancer cells to chemotherapy

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Metabolic reprogramming during neuronal differentiation

(2016) M Agostini et al.   CELL DEATH AND DIFFERENTIATION

Precision targeted therapy of ovarian cancer

(2016) Justin Sapiezynski et al.   JOURNAL OF CONTROLLED RELEASE

Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma

(2016) Chioniso Patience Masamha et al.   Journal of Hematology & Oncology

CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function

(2016) Chioniso P. Masamha et al.   RNA

Cell Death and Cancer Therapy: Don't Forget to Kill the Cancer Cell!

(2015) A. Letai   CLINICAL CANCER RESEARCH

Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway

(2015) Lingqin Yuan et al.   ENDOCRINE-RELATED CANCER

Silencing of glutaminase 1 resensitizes Taxol-resistant breast cancer cells to Taxol

(2015) AIQIN FU et al.   Molecular Medicine Reports

YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells

(2015) G Hua et al.   ONCOGENE

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

(2014) L. Yang et al.   Molecular Systems Biology

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

(2014) Zheng Xia et al.   Nature Communications

Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)

(2014) K. Thangavelu et al.   Scientific Reports

The role of the fallopian tube in the origin of ovarian cancer

(2013) Britt K. Erickson et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

In vitro three-dimensional modeling of fallopian tube secretory epithelial cells

(2013) Kate Lawrenson et al.   BMC CELL BIOLOGY

Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models

(2013) Ruth Perets et al.   CANCER CELL

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation

(2013) Tania Velletri et al.   CELL CYCLE

Glutaminase regulation in cancer cells: a druggable chain of events

(2013) William P. Katt et al.   DRUG DISCOVERY TODAY

Therapeutic strategies impacting cancer cell glutamine metabolism

(2013) Michael J Lukey et al.   Future Medicinal Chemistry

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Epithelial ovarian cancer experimental models

(2013) E Lengyel et al.   ONCOGENE

Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells

(2013) Monika Szeliga et al.   TUMOR BIOLOGY

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Evaluating cell lines as tumour models by comparison of genomic profiles

(2013) Silvia Domcke et al.   Nature Communications

Analysis of glutamine dependency in non-small cell lung cancer

(2012) A. Pieter J. van den Heuvel et al.   CANCER BIOLOGY & THERAPY

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

(2012) A. Cassago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor

(2011) Byron DeLaBarre et al.   BIOCHEMISTRY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Targeting cancer metabolism – aiming at a tumour's sweet-spot

(2011) Neil P. Jones et al.   DRUG DISCOVERY TODAY

Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia

(2011) Hsiu-Ni Kung et al.   PLoS Genetics

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements

(2010) Shivanni Kummar et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evaluation of New Platinum-Based Treatment Regimens in Advanced-Stage Ovarian Cancer: A Phase III Trial of the Gynecologic Cancer InterGroup

(2009) Michael A. Bookman et al.   JOURNAL OF CLINICAL ONCOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

A novel glutaminase isoform in mammalian tissues

(2009) Vanessa de la Rosa et al.   NEUROCHEMISTRY INTERNATIONAL

Glutamine in neoplastic cells: Focus on the expression and roles of glutaminases

(2009) Monika Szeliga et al.   NEUROCHEMISTRY INTERNATIONAL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA