The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)

A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments

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Neuronal sphingolipidoses: Membrane lipids and sphingolipid activator proteins regulate lysosomal sphingolipid catabolism

(2016) Konrad Sandhoff   BIOCHIMIE

Is it Fabry disease?

(2016) Raphael Schiffmann et al.   GENETICS IN MEDICINE

Cholesterol-dependent increases in glucosylceramide synthase activity in Niemann-Pick disease type C model cells: Abnormal trafficking of endogenously formed ceramide metabolites by inhibition of the enzyme

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Tamoxifen regulation of sphingolipid metabolism—Therapeutic implications

(2015) Samy A.F. Morad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells

(2015) Andreas Tyler et al.   EXPERIMENTAL CELL RESEARCH

Sustained Epigenetic Drug Delivery Depletes Cholesterol–Sphingomyelin Rafts from Resistant Breast Cancer Cells, Influencing Biophysical Characteristics of Membrane Lipids

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Curcumin induces p53-independent necrosis in H1299 cells via a mitochondria-associated pathway

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Identification and characterization of essential genes in the human genome

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Identification of estrogen-responsive genes based on the DNA binding properties of estrogen receptors using high-throughput sequencing technology

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Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1

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Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation

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Expression of glucosylceramide synthase in invasive ductal breast cancer may be correlated with high estrogen receptor status and low HER-2 status

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Mechanism of the reversal effect of mifepristone on drug resistance of the human cervical cancer cell line HeLa/MMC

(2014) H. Chen et al.   GENETICS AND MOLECULAR RESEARCH

Glucosylceramide synthase promotes Bcl-2 expression via the ERK signaling pathway in the K562/A02 leukemia drug-resistant cell line

(2014) Qian Wang et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

(2014) Frances Jane Sharom   Frontiers in Oncology

Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles

(2013) Chiranjeevi Peetla et al.   ADVANCED DRUG DELIVERY REVIEWS

New insights on glucosylated lipids: Metabolism and functions

(2013) Yohei Ishibashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Glycosphingolipids: synthesis and functions

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Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing

(2013) Nicole Amen et al.   HUMAN MOLECULAR GENETICS

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Cell-specific in vivo functions of glycosphingolipids: Lessons from genetic deletions of enzymes involved in glycosphingolipid synthesis

(2013) Richard Jennemann et al.   PROGRESS IN LIPID RESEARCH

Estrogen synthesis and signaling pathways during aging: from periphery to brain

(2013) Jie Cui et al.   TRENDS IN MOLECULAR MEDICINE

DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells

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Molecular Pathways: Regulation and Therapeutic Implications of Multidrug Resistance

(2012) K. G. Chen et al.   CLINICAL CANCER RESEARCH

Doxorubicin Influences the Expression of Glucosylceramide Synthase in Invasive Ductal Breast Cancer

(2012) Xiaofang Zhang et al.   PLoS One

MDR1 (multidrug resistence 1) can regulate GCS (glucosylceramide synthase) in breast cancer cells

(2011) Xiaofang Zhang et al.   JOURNAL OF SURGICAL ONCOLOGY

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling

(2010) Yong-Yu Liu et al.   Molecular Cancer

Targeting glucosylceramide synthase downregulates expression of the multidrug resistance gene MDR1 and sensitizes breast carcinoma cells to anticancer drugs

(2009) Yanlin Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

c-Fos Activates Glucosylceramide Synthase and Glycolipid Synthesis in PC12 Cells

(2008) Pilar M. Crespo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY