Targeting Tumor Microenvironment for Cancer Therapy

Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity

(2019) Michela Capello et al.   Nature Communications

Relative Dose Intensity of Induction-Phase Pazopanib Treatment of Soft Tissue Sarcoma: Its Relationship with Prognoses of Pazopanib Responders

(2019) Kenji Nakano et al.   Journal of Clinical Medicine

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents

(2018) Matteo Santoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics

(2018) Marta Overchuk et al.   BIOMATERIALS

Cancer Energy Metabolism: Shutting Power off Cancer Factory

(2018) Soo-Youl Kim   Biomolecules & Therapeutics

Metabolic features of macrophages in inflammatory diseases and cancer

(2018) Yi Rang Na et al.   CANCER LETTERS

Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction

(2018) Rebecca J. Boohaker et al.   CANCER LETTERS

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship

(2018) Romana T. Netea-Maier et al.   CANCER LETTERS

Tyrosine kinase inhibitors for brain metastases in HER2-positive breast cancer

(2018) Renata Duchnowska et al.   CANCER TREATMENT REVIEWS

The role of IL-1B in breast cancer bone metastasis

(2018) Claudia Tulotta et al.   ENDOCRINE-RELATED CANCER

Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site

(2018) Srishti Singh et al.   MOLECULES

Tumor-on-a-chip platforms for assessing nanoparticle-based cancer therapy

(2018) Yimin Wang et al.   NANOTECHNOLOGY

Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?

(2018) RD Coletta et al.   ORAL DISEASES

Tumor-derived exosomes, microRNAs, and cancer immune suppression

(2018) Michael W. Graner et al.   Seminars in Immunopathology

The role of macrophage phenotype in regulating the response to radiation therapy

(2018) Xiaoshan Shi et al.   Translational Research

MMP-Responsive ‘Smart’ Drug Delivery and Tumor Targeting

(2018) Qing Yao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening

(2018) Andrea R. Mazzocchi et al.   Scientific Reports

Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment

(2018) Sundary Sormendi et al.   Frontiers in Immunology

Teaming Up for Trouble: Cancer Cells, Transforming Growth Factor-β1 Signaling and the Epigenetic Corruption of Stromal Naïve Fibroblasts

(2018) Sergio Lamprecht et al.   Cancers

Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008–2018)

(2018) Alessio Nocentini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Development of a biomimetic liver tumor-on-a-chip model based on decellularized liver matrix for toxicity testing

(2018) Siming Lu et al.   LAB ON A CHIP

Applications of tumor chip technology

(2018) Stephanie J. Hachey et al.   LAB ON A CHIP

The Tumor Vascular Endothelium as Decision Maker in Cancer Therapy

(2018) Diana Klein   Frontiers in Oncology

A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells

(2018) Julio Aleman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Conophylline suppresses pancreatic cancer desmoplasia and cancer‐promoting cytokines produced by cancer‐associated fibroblasts

(2018) Norihiro Ishii et al.   CANCER SCIENCE

Exploratory Investigation of Target Pazopanib Concentration Range for Patients With Renal Cell Carcinoma

(2018) Satoshi Noda et al.   Clinical Genitourinary Cancer

A Matrix Metalloproteinase-1 Polymorphism, MMP1–1607 (1G>2G), Is Associated with Increased Cancer Risk: A Meta-Analysis Including 21,327 Patients

(2018) Zhonghan Zhou et al.   DISEASE MARKERS

Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?

(2018) Tingkai Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors

(2018) Claudiu T. Supuran   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo

(2018) Deby F. Mardhian et al.   JOURNAL OF CONTROLLED RELEASE

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

(2018) Yuan Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosomes Derived from Human Primary and Metastatic Colorectal Cancer Cells Contribute to Functional Heterogeneity of Activated Fibroblasts by Reprogramming Their Proteome

(2018) Alin Rai et al.   PROTEOMICS

Ex Vivo Tumor-on-a-Chip Platforms to Study Intercellular Interactions within the Tumor Microenvironment

(2018) Vardhman Kumar et al.   Advanced Healthcare Materials

Serious adverse events and fatal adverse events associated with nivolumab treatment in cancer patients

(2018) Bin Zhao et al.   Journal for ImmunoTherapy of Cancer

Exosome-Mediated Signaling in Epithelial to Mesenchymal Transition and Tumor Progression

(2018) Alice Conigliaro et al.   Journal of Clinical Medicine

Risk of gastrointestinal events with newly approved (after 2011) vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: a meta-analysis of randomized controlled trials

(2017) Jing Li et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Targeted therapies in non-small cell lung cancer: a focus on ALK/ROS1 tyrosine kinase inhibitors

(2017) Assunta Sgambato et al.   Expert Review of Anticancer Therapy

IL-1 and IL-1 regulatory pathways in cancer progression and therapy

(2017) Alberto Mantovani et al.   IMMUNOLOGICAL REVIEWS

Tumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy

(2017) Maryam Tahmasebi Birgani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor Microenvironment Modulation via Gold Nanoparticles Targeting Malicious Exosomes: Implications for Cancer Diagnostics and Therapy

(2017) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Newly Emerging Immune Checkpoints: Promises for Future Cancer Therapy

(2017) Robert Torphy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

(2017) Robert H. Scannevin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted delivery of novel chemotherapeutic agents

(2017) Alexandra R. Fernandes et al.   JOURNAL OF CONTROLLED RELEASE

In Vivo Imaging of Pro- and Antitumoral Cellular Components of the Tumor Microenvironment

(2017) Anne Helfen et al.   JOURNAL OF NUCLEAR MEDICINE

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

Microfluidic modeling of the biophysical microenvironment in tumor cell invasion

(2017) Yu Ling Huang et al.   LAB ON A CHIP

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression

(2017) Zongyuan Yang et al.   Molecular Cancer

Tumor-related interleukins: old validated targets for new anti-cancer drug development

(2017) Sarra Setrerrahmane et al.   Molecular Cancer

Smuggling gold nanoparticles across cell types – A new role for exosomes in gene silencing

(2017) Catarina Roma-Rodrigues et al.   Nanomedicine-Nanotechnology Biology and Medicine

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation

(2017) Elizabeth Allen et al.   Science Translational Medicine

Therapeutic implications of tumor interstitial acidification

(2017) Iryna Kolosenko et al.   SEMINARS IN CANCER BIOLOGY

The role of exosomes in cancer metastasis

(2017) Teresa Bernadette Steinbichler et al.   SEMINARS IN CANCER BIOLOGY

Intratumor and Intertumor Heterogeneity in Melanoma

(2017) Tomasz M. Grzywa et al.   Translational Oncology

Breaking Down the Barriers to Precision Cancer Nanomedicine

(2017) Christina von Roemeling et al.   TRENDS IN BIOTECHNOLOGY

Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy

(2017) Tianchi Yu et al.   YONSEI MEDICAL JOURNAL

Cytokines in Cancer Immunotherapy

(2017) Thomas A. Waldmann   Cold Spring Harbor Perspectives in Biology

A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models

(2017) Binbing Ling et al.   Oncotarget

Matrix metalloproteinase MMP9 maintains epithelial barrier function and preserves mucosal lining in colitis associated cancer

(2017) Adani Pujada et al.   Oncotarget

The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma

(2017) Rhiannon Coulson et al.   Oncotarget

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Role of tumor microenvironment in tumorigenesis

(2017) Maonan Wang et al.   Journal of Cancer

The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the Tumor Microenvironment Niche

(2017) Cosette M. Rivera-Cruz et al.   Stem Cells International

Combination therapy using molecular-targeted drugs modulates tumor microenvironment and impairs tumor growth in renal cell carcinoma

(2017) Hiroyuki Kitano et al.   Cancer Medicine

Drug Repositioning of Proton Pump Inhibitors for Enhanced Efficacy and Safety of Cancer Chemotherapy

(2017) Kenji Ikemura et al.   Frontiers in Pharmacology

Gold Nanoparticle Approach to the Selective Delivery of Gene Silencing in Cancer—The Case for Combined Delivery?

(2017) Rita Mendes et al.   Genes

Exosomes in blood and cancer

(2017) Edward R. Sauter   Translational Cancer Research

Exosomes in lymph and cancer

(2017) Edward R. Sauter   Translational Cancer Research

A pilot trial of oral topotecan (TPT) in patients with refractory advanced solid neoplasms expressing HIF-1α.

(2017) A. G. Duffy et al.   JOURNAL OF CLINICAL ONCOLOGY

Annexin-A1 enhances breast cancer growth and migration by promoting alternative macrophage polarization in the tumour microenvironment

(2017) Leonardo A. Moraes et al.   Scientific Reports

Targeting myeloid cells in the tumor sustaining microenvironment

(2017) Jonathan Schupp et al.   CELLULAR IMMUNOLOGY

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

(2016) Yoshihiro Komohara et al.   ADVANCED DRUG DELIVERY REVIEWS

3D tumor spheroids: an overview on the tools and techniques used for their analysis

(2016) Elisabete C. Costa et al.   BIOTECHNOLOGY ADVANCES

Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs

(2016) Vítor E. Santo et al.   Biotechnology Journal

The Emerging Role of Tyrosine Kinase Inhibitors in Ovarian Cancer Treatment: A Systematic Review

(2016) Ioannis Ntanasis-Stathopoulos et al.   CANCER INVESTIGATION

Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip

(2016) Bumsoo Han et al.   CANCER LETTERS

Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

(2016) Laetitia E. Lamberts et al.   CLINICAL CANCER RESEARCH

Old Tyrosine Kinase Inhibitors and Newcomers in Gastrointestinal Cancer Treatment

(2016) Giordani Erika et al.   CURRENT CANCER DRUG TARGETS

Comparison of functional limbal epithelial stem cell isolation methods

(2016) Marina López-Paniagua et al.   EXPERIMENTAL EYE RESEARCH

Advances in structure-based drug discovery of carbonic anhydrase inhibitors

(2016) Claudiu T. Supuran   Expert Opinion on Drug Discovery

Emerging tyrosine kinase inhibitors for the treatment of metastatic colorectal cancer

(2016) Ignacio Matos et al.   EXPERT OPINION ON EMERGING DRUGS

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

(2016) F. Danhier   JOURNAL OF CONTROLLED RELEASE

ExoCarta: A Web-Based Compendium of Exosomal Cargo

(2016) Shivakumar Keerthikumar et al.   JOURNAL OF MOLECULAR BIOLOGY

The Roles of Mesenchymal Stromal/Stem Cells in Tumor Microenvironment Associated with Inflammation

(2016) Drenka Trivanović et al.   MEDIATORS OF INFLAMMATION

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

(2016) YAO YUAN et al.   ONCOLOGY REPORTS

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

Tyrosine Kinase Inhibitors and Vascular Toxicity: Impetus for a Classification System?

(2016) Joerg Herrmann   Current Oncology Reports

The mTOR/AP-1/VEGF signaling pathway regulates vascular endothelial cell growth

(2016) Shuo Wang et al.   Oncotarget

IL-1 drives breast cancer growth and bone metastasis in vivo

(2016) Ingunn Holen et al.   Oncotarget

Targeting hypoxic response for cancer therapy

(2016) Elisa Paolicchi et al.   Oncotarget

Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs

(2016) Vítor E. Santo et al.   Biotechnology Journal

Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review

(2016) Navid Kashaninejad et al.   Micromachines

Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint Therapy

(2016) Xinqi Wu et al.   Cancer Immunology Research

Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors

(2016) Rikke B. Holmgaard et al.   EBioMedicine

A Meta-Analysis of Adjuvant Therapy after Potentially Curative Treatment for Hepatocellular Carcinoma

(2016) Jun Wang et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

New horizons in tumor microenvironment biology: challenges and opportunities

(2015) Fei Chen et al.   BMC Medicine

Nanomedicines Targeting the Tumor Microenvironment

(2015) Rong Tong et al.   CANCER JOURNAL

Tumor microenvironment: Sanctuary of the devil

(2015) Lanlan Hui et al.   CANCER LETTERS

Tissue-engineered models of human tumors for cancer research

(2015) Aranzazu Villasante et al.   Expert Opinion on Drug Discovery

Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting

(2015) Evan J Lipson et al.   Journal of Translational Medicine

Evaluating Biomaterial- and Microfluidic-Based 3D Tumor Models

(2015) Mariana R. Carvalho et al.   TRENDS IN BIOTECHNOLOGY

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Microfluidic 3D models of cancer

(2014) Kyung Eun Sung et al.   ADVANCED DRUG DELIVERY REVIEWS

Modeling human carcinomas: Physiologically relevant 3D models to improve anti-cancer drug development

(2014) Christine Unger et al.   ADVANCED DRUG DELIVERY REVIEWS

Probing the relevance of 3D cancer models in nanomedicine research

(2014) David T. Leong et al.   ADVANCED DRUG DELIVERY REVIEWS

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

3D tumor models: history, advances and future perspectives

(2014) Parul Benien et al.   Future Oncology

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

(2014) Alessandra De Remigis et al.   INTERNATIONAL JOURNAL OF CANCER

Combined Vemurafenib and Cobimetinib in BRAF-Mutated Melanoma

(2014) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Three-dimensional in vitro cancer models: a short review

(2014) Chengyang Wang et al.   Biofabrication

Characterization of Uptake and Internalization of Exosomes by Bladder Cancer Cells

(2014) Carrie A. Franzen et al.   Biomed Research International

Exosome in Tumour Microenvironment: Overview of the Crosstalk between Normal and Cancer Cells

(2014) Catarina Roma-Rodrigues et al.   Biomed Research International

Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab

(2014) Saskia JAM Santegoets et al.   Journal for ImmunoTherapy of Cancer

Antitumor efficacy of the heparanase inhibitor SST0001 alone and in combination with antiangiogenic agents in the treatment of human pediatric sarcoma models

(2013) G. Cassinelli et al.   BIOCHEMICAL PHARMACOLOGY

Heparanase in inflammation and inflammation-associated cancer

(2013) Amichay Meirovitz et al.   FEBS Journal

Vemurafenib reverses immunosuppression by myeloid derived suppressor cells

(2013) Bastian Schilling et al.   INTERNATIONAL JOURNAL OF CANCER

Strategies for advancing cancer nanomedicine

(2013) Vikash P. Chauhan et al.   NATURE MATERIALS

Tumor and its microenvironment: A synergistic interplay

(2013) Veronica Catalano et al.   SEMINARS IN CANCER BIOLOGY

MMP1-1607(1G>2G) polymorphism and the risk of lung cancer in Lebanon

(2012) Hana Fakhoury et al.   Annals of Thoracic Medicine

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Targeting the Tumor Microenvironment for Cancer Therapy

(2012) N. E. Sounni et al.   CLINICAL CHEMISTRY

The role of the myofibroblast in tumor stroma remodeling

(2012) Marcela Otranto et al.   Cell Adhesion & Migration

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

(2011) Jingqi Chen et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading

(2011) Rainelli B. Koumangoye et al.   PLoS One

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

(2010) David G. DeNardo et al.   CANCER AND METASTASIS REVIEWS

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Microvesicles: mediators of extracellular communication during cancer progression

(2010) V. Muralidharan-Chari et al.   JOURNAL OF CELL SCIENCE

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

(2010) Jung Eun Park et al.   MOLECULAR & CELLULAR PROTEOMICS

(Pre-)Clinical Pharmacology and Activity of Pazopanib, a Novel Multikinase Angiogenesis Inhibitor

(2010) P. Hamberg et al.   ONCOLOGIST

Colony-Stimulating Factor-1 Receptor Inhibitors for the Treatment of Cancer and Inflammatory Disease

(2009) Sharmila Patel et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY