- Home
- Publications
- Publication Search
- Publication Details
Title
Methionine is a metabolic dependency of tumor-initiating cells
Authors
Keywords
-
Journal
NATURE MEDICINE
Volume 25, Issue 5, Pages 825-837
Publisher
Springer Science and Business Media LLC
Online
2019-05-09
DOI
10.1038/s41591-019-0423-5
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells
- (2019) Taylor Freeman et al. Cancers
- Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation
- (2019) Michael A. Davis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment
- (2019) Pasquale Zizza et al. NUCLEIC ACIDS RESEARCH
- Identification of Tumor Initiating Cells with a Small-Molecule Fluorescent Probe by Using Vimentin as a Biomarker
- (2018) Yong-An Lee et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing
- (2018) Sarah V. Gerhart et al. Scientific Reports
- Molecular dissection of cone photoreceptor-enriched genes encoding transmembrane and secretory proteins
- (2018) Samantha Papal et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells
- (2018) Silvia García-López et al. PLoS One
- H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells
- (2018) Lijun Wang et al. PLOS BIOLOGY
- Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A
- (2017) Casey L Quinlan et al. Nature Chemical Biology
- Cancer stem cells revisited
- (2017) Eduard Batlle et al. NATURE MEDICINE
- Metabolic Interactions in the Tumor Microenvironment
- (2017) Costas A. Lyssiotis et al. TRENDS IN CELL BIOLOGY
- Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
- (2016) Shawn M. Davidson et al. Cell Metabolism
- Novel therapeutic targets on the horizon for lung cancer
- (2016) Wan-Ling Tan et al. LANCET ONCOLOGY
- Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells
- (2016) Oliver D.K. Maddocks et al. MOLECULAR CELL
- Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
- (2016) J. R. Mayers et al. SCIENCE
- Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
- (2016) Sarah Cooper et al. Nature Communications
- MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
- (2016) Katya Marjon et al. Cell Reports
- Characterization of the Methylthioadenosine Phosphorylase Polymorphism rs7023954 - Incidence and Effects on Enzymatic Function in Malignant Melanoma
- (2016) Katharina Limm et al. PLoS One
- Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle
- (2015) Tiago C. Alves et al. Cell Metabolism
- SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
- (2015) Dohoon Kim et al. NATURE
- Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)
- (2015) Xia Jiang et al. PLoS One
- Famine versus feast: understanding the metabolism of tumors in vivo
- (2015) Jared R. Mayers et al. TRENDS IN BIOCHEMICAL SCIENCES
- Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity
- (2015) Shuya Yano et al. Oncotarget
- Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells
- (2014) Nobuaki Shiraki et al. Cell Metabolism
- Evolution of the Cancer Stem Cell Model
- (2014) Antonija Kreso et al. Cell Stem Cell
- Metastatic Stem Cells: Sources, Niches, and Vital Pathways
- (2014) Thordur Oskarsson et al. Cell Stem Cell
- Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
- (2014) Bryce W. Carey et al. NATURE
- Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells
- (2014) Christiaan F. Labuschagne et al. Cell Reports
- Fluorinated N,N-Dialkylaminostilbenes Repress Colon Cancer by Targeting Methionine S-Adenosyltransferase 2A
- (2013) Wen Zhang et al. ACS Chemical Biology
- SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
- (2013) Eric Letouzé et al. CANCER CELL
- Influence of Metabolism on Epigenetics and Disease
- (2013) William G. Kaelin et al. CELL
- Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia
- (2013) Ma'atem B. Fofou-Caillierez et al. HUMAN MOLECULAR GENETICS
- Methionine Adenosyltransferase II-dependent Histone H3K9 Methylation at theCOX-2Gene Locus
- (2013) Yohei Kera et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
- (2013) Jaekyoung Son et al. NATURE
- Tumour heterogeneity and cancer cell plasticity
- (2013) Corbin E. Meacham et al. NATURE
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis
- (2012) Wen Cai Zhang et al. CELL
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
- (2012) Jinghui Zhang et al. NATURE
- Serine is a natural ligand and allosteric activator of pyruvate kinase M2
- (2012) Barbara Chaneton et al. NATURE
- Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
- (2012) Oliver D. K. Maddocks et al. NATURE
- Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation
- (2012) N. Shyh-Chang et al. SCIENCE
- Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
- (2012) M. Jain et al. SCIENCE
- Cancer Cell Metabolism: One Hallmark, Many Faces
- (2012) Jason R. Cantor et al. Cancer Discovery
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein
- (2011) Yasutake Katoh et al. MOLECULAR CELL
- Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
- (2011) Richard Possemato et al. NATURE
- Increased methylation variation in epigenetic domains across cancer types
- (2011) Kasper Daniel Hansen et al. NATURE GENETICS
- Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
- (2011) Jason W Locasale et al. NATURE GENETICS
- Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
- (2011) Oliver G McDonald et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
- (2011) D. Anastasiou et al. SCIENCE
- Glutamine addiction: a new therapeutic target in cancer
- (2010) David R. Wise et al. TRENDS IN BIOCHEMICAL SCIENCES
- Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse
- (2009) C Kahlert et al. BRITISH JOURNAL OF CANCER
- DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
- (2009) T. B. Miranda et al. MOLECULAR CANCER THERAPEUTICS
- Cancer Stem Cells in Solid Tumors: An Overview
- (2009) Catherine Adell O'Brien et al. SEMINARS IN RADIATION ONCOLOGY
- Tumor Immunobiological Differences in Prostate Cancer between African-American and European-American Men
- (2008) T. A. Wallace et al. CANCER RESEARCH
- A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer
- (2008) T. Bonome et al. CANCER RESEARCH
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started