Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives

The senescence-associated secretory phenotype and its regulation

(2019) Stéphane Lopes-Paciencia et al.   CYTOKINE

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

(2019) Nathan D. Seligson et al.   Oncotarget

SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling

(2018) Kwi Shan Seah et al.   EXPERIMENTAL CELL RESEARCH

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

(2018) Christopher D. Wiley et al.   Scientific Reports

The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest

(2018) Chan-Woo Park et al.   Frontiers in Pharmacology

Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR–CHK1, p21, and NF-κB

(2018) Dorthe Aasland et al.   CANCER RESEARCH

Senescent tumor cells lead the collective invasion in thyroid cancer

(2017) Young Hwa Kim et al.   Nature Communications

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

(2017) Liqin Wang et al.   Cell Reports

Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion

(2017) Satoshi Furuya et al.   FEBS Open Bio

Cristacarpin promotes ER stress-mediated ROS generation leading to premature senescence by activation of p21waf-1

(2016) Souneek Chakraborty et al.   AGE

Context-dependent effects of cellular senescence in cancer development

(2016) Pacome Lecot et al.   BRITISH JOURNAL OF CANCER

Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer

(2016) Joana Tato-Costa et al.   Clinical Colorectal Cancer

Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma

(2016) Julien Bollard et al.   GUT

ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1

(2016) Oriol de Barrios et al.   GUT

Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM-independent manner

(2015) Wioleta Grabowska et al.   AGE

NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation

(2015) Hao Tang et al.   Aging-US

Persistent DNA damage-induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells

(2015) Valentina Minieri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells

(2015) Guiqin Xu et al.   Oncotarget

FL118 Induces p53-Dependent Senescence in Colorectal Cancer Cells by Promoting Degradation of MdmX

(2014) X. Ling et al.   CANCER RESEARCH

hRAD9 functions as a tumor suppressor by inducing p21-dependent senescence and suppressing epithelial–mesenchymal transition through inhibition of Slug transcription

(2014) Fan-Chih Wen et al.   CARCINOGENESIS

Oncogene-induced senescence: An essential role for Runx

(2014) Anne Terry et al.   CELL CYCLE

Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis

(2014) Yingqiu Xie et al.   Molecular Oncology

Decreased Skp2 Expression Is Necessary but Not Sufficient for Therapy-Induced Senescence in Prostate Cancer

(2014) Jonathan A. Ewald et al.   Translational Oncology

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin

(2013) Anna Litwiniec et al.   Cancer Cell International

Sequential Inductions of the ZEB1 Transcription Factor Caused by Mutation of Rb and Then Ras Proteins Are Required for Tumor Initiation and Progression

(2013) Yongqing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene-Driven Non–Small Cell Lung Cancer

(2013) Timothy F. Burns et al.   MOLECULAR CANCER RESEARCH

Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2'-Deoxycytidine in Solid Tumor Cells

(2013) S. Venturelli et al.   MOLECULAR CANCER THERAPEUTICS

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

The β-carboline alkaloid harmine inhibits telomerase activity of MCF-7 cells by down-regulating hTERT mRNA expression accompanied by an accelerated senescent phenotype

(2013) Lei Zhao et al.   PeerJ

A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma

(2012) Yuan Yuan et al.   ACS Chemical Biology

CDKN1C/P57 Is Regulated by the Notch Target Gene Hes1 and Induces Senescence in Human Hepatocellular Carcinoma

(2012) Catia Giovannini et al.   AMERICAN JOURNAL OF PATHOLOGY

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Phenylbutyric acid induces the cellular senescence through an Akt/p21WAF1 signaling pathway

(2012) Hag Dong Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells

(2012) Thanachai Taka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity

(2012) Fong-Chun Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence

(2012) Elise McKenna et al.   CELL CYCLE

Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer

(2012) Yoshimi Arima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

(2012) Sebastian Müller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Twist1 Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant Kras-Induced Lung Tumorigenesis

(2012) Phuoc T. Tran et al.   PLoS Genetics

Contrasting Behavior of the p18INK4c and p16INK4a Tumor Suppressors in Both Replicative and Oncogene-Induced Senescence

(2011) S. Gagrica et al.   CANCER RESEARCH

p53 regulation by ubiquitin

(2011) Christopher L. Brooks et al.   FEBS LETTERS

Cellular senescence and tumor suppressor gene p16

(2011) Hani Rayess et al.   INTERNATIONAL JOURNAL OF CANCER

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

The basics of epithelial-mesenchymal transition

(2011) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of p53 by Nutlin-3a Induces Apoptosis and Cellular Senescence in Human Glioblastoma Multiforme

(2011) Ruth Villalonga-Planells et al.   PLoS One

p16INK4A Positively Regulates Cyclin D1 and E2F1 through Negative Control of AUF1

(2011) Huda H. Al-Khalaf et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras

(2010) Arunasalam Navaraj et al.   CANCER BIOLOGY & THERAPY

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

(2010) Agustin Chicas et al.   CANCER CELL

Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines

(2010) Modjtaba Emadi Baygi et al.   CELL BIOLOGY AND TOXICOLOGY

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo

(2010) J. J. Huck et al.   MOLECULAR CANCER RESEARCH

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity

(2010) Elisabeth Ersvaer et al.   Toxins

Cyclophosphamide induces premature senescence in normal human fibroblasts by activating MAP kinases

(2009) Arivazhagan Palaniyappan   BIOGERONTOLOGY

Metastasis-induction and apoptosis-protection by TWIST in gastric cancer cells

(2009) Mei-yan Feng et al.   CLINICAL & EXPERIMENTAL METASTASIS

Ceramide Regulates Gemcitabine-Induced Senescence and Apoptosis in Human Pancreatic Cancer Cell Lines

(2009) D. E. Modrak et al.   MOLECULAR CANCER RESEARCH

SOCS1 Links Cytokine Signaling to p53 and Senescence

(2009) Viviane Calabrese et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

Twist and p53 reciprocally regulate target genes via direct interaction

(2008) M Shiota et al.   ONCOGENE

Histone Deacetylase Inhibitors Promote Apoptosis and Senescence in Human Mesenchymal Stem Cells

(2008) Giovanni Di Bernardo et al.   STEM CELLS AND DEVELOPMENT

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY