Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway

Mxd1 mediates hypoxia-induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene

(2017) Datong Zheng et al.   MOLECULAR CARCINOGENESIS

Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer

(2017) Junlian Gu et al.   Scientific Reports

KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension

(2016) Xiaochen Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer

(2016) Matthew J. Boyer et al.   LUNG CANCER

Upregulation of ABCG2 via the PI3K-Akt pathway contributes to acidic microenvironment-induced cisplatin resistance in A549 and LTEP-a-2 lung cancer cells

(2016) CHUN FANG HU et al.   ONCOLOGY REPORTS

Targeting Kruppel-Like Factor 5 (KLF5) for Cancer Therapy

(2015) Yu Gao et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization

(2015) Carina Fischer et al.   Molecular Cancer

KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2

(2015) L Jia et al.   ONCOGENE

PI3K/AKT/mTOR signaling pathway as a therapeutic target for ovarian cancer

(2014) HaiXia Li et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Increased drug resistance is associated with reduced glucose levels and an enhanced glycolysis phenotype

(2014) B Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

KLF5 promotes hypoxia-induced survival and inhibits apoptosis in non-small cell lung cancer cells via HIF-1α

(2014) XIAOCHEN LI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway

(2014) FENGLIN CHEN et al.   ONCOLOGY REPORTS

HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein

(2014) Jianfang Chen et al.   PLoS One

Systems biology of cisplatin resistance: past, present and future

(2014) L Galluzzi et al.   Cell Death & Disease

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

(2014) Takehiro Yamamoto et al.   Nature Communications

Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

(2013) Howard A. Burris   CANCER CHEMOTHERAPY AND PHARMACOLOGY

SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non-Small Cell Lung Cancers to Cisplatin and Doxorubicin

(2013) D. H. Shin et al.   CANCER RESEARCH

KLF5 strengthens drug resistance of ovarian cancer stem-like cells by regulating survivin expression

(2013) Z. Dong et al.   CELL PROLIFERATION

Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism

(2013) Yi Xuan et al.   EXPERIMENTAL CELL RESEARCH

Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1α

(2013) Xiangjun Ji et al.   INTERNATIONAL JOURNAL OF CANCER

The double life of KLF5: Opposing roles in regulation of gene-expression, cellular function, and transformation

(2013) Sonya M. Diakiw et al.   IUBMB LIFE

Cancer cell bioenergetics and pH regulation influence breast cancer cell resistance to paclitaxel and doxorubicin

(2013) Diana Tavares-Valente et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Krüppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2Synthase 1 Gene Transcription in Breast Cancer

(2013) Houjun Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway

(2013) Hu Wang et al.   MOLECULAR CARCINOGENESIS

Tumour Hypoxia Affects the Responsiveness of Cancer Cells to Chemotherapy and Promotes Cancer Progression

(2012) Jean-Philippe Cosse et al.   Anti-Cancer Agents in Medicinal Chemistry

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells

(2011) Christoph Wohlkoenig et al.   CANCER LETTERS

The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia

(2011) Sonya M. Diakiw et al.   LEUKEMIA RESEARCH

Krüppel-Like Factor 5 Is Not Required for K-RasG12D Lung Tumorigenesis, but Represses ABCG2 Expression and Is Associated with Better Disease-Specific Survival

(2010) Sara E. Meyer et al.   AMERICAN JOURNAL OF PATHOLOGY

Novel insights into the molecular origins and treatment of lung cancer

(2010) James D. Webb et al.   CELL CYCLE

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

(2009) Jin-Tang Dong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multidrug Resistance Through the Spectacle of P-Glycoprotein

(2009) Katalin Goda et al.   CURRENT CANCER DRUG TARGETS

Inhibitors of the PI3K/Akt/mTOR Pathway: New Hope for Breast Cancer Patients

(2009) Sandra Ghayad et al.   Recent Patents on Anti-Cancer Drug Discovery