Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development
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Title
Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development
Authors
Keywords
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Journal
PHYSIOLOGICAL REVIEWS
Volume 98, Issue 2, Pages 919-1053
Publisher
American Physiological Society
Online
2018-03-14
DOI
10.1152/physrev.00025.2017
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- ANP attenuates inflammatory signaling and Rho pathway of lung endothelial permeability induced by LPS and TNFα
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- Direct Spatial Control of Epac1 by Cyclic AMP
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- Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle
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- Expression and Activity of Phosphodiesterase Isoforms during Epithelial Mesenchymal Transition: The Role of Phosphodiesterase 4
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- N6-Substituted cAMP Analogs Inhibit bTREK-1 K+ Channels and Stimulate Cortisol Secretion by a Protein Kinase A-Independent Mechanism
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- Protein Kinase A and B-Raf Mediate Extracellular Signal-Regulated Kinase Activation by Thyrotropin
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- cAMP Analogs and Their Metabolites Enhance TREK-1 mRNA and K+ Current Expression in Adrenocortical Cells
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- Deficiency of the Housekeeping Gene Hypoxanthine–Guanine Phosphoribosyltransferase (HPRT) Dysregulates Neurogenesis
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- Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion
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- Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
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- Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2
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- Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus
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- The cAMP/Epac1/Rap1 Pathway in Pancreatic Carcinoma
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- Metabolites of an Epac-Selective cAMP Analog Induce Cortisol Synthesis by Adrenocortical Cells through a cAMP-Independent Pathway
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- Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages
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- The cAMP binding protein Epac regulates cardiac myofilament function
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- The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs
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- Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
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- Merlin and the ERM proteins – regulators of receptor distribution and signaling at the cell cortex
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- Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors
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- Evaluating the glucose tolerance test in mice
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- Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic α- and intestinal L-cell lines
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- Cyclic AMP accelerates calcium waves in pancreatic acinar cells
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- Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration
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- Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle α2C-adrenoceptors
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- Activation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxation
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- Prostaglandin E2Inhibits Specific Lung Fibroblast Functions via Selective Actions of PKA and Epac-1
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- The Adenosine A2a Receptor Inhibits Matrix-Induced Inflammation in a Novel Fashion
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- β2 Integrins target Rap GTPases to the plasma membrane by means of degranulation
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- Quantitative Measurement of cAMP Concentration Using an Exchange Protein Directly Activated by a cAMP-Based FRET-Sensor
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- Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion
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- The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway
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- TLR4/MYD88-dependent, LPS-induced synthesis of PGE2 by macrophages or dendritic cells prevents anti-CD3-mediated CD95L upregulation in T cells
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- The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages
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- 8-pCPT-2′-O-Me-cAMP-AM: An Improved Epac-Selective cAMP Analogue
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- Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy
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- Hyaluronan (HA) Deposition Precedes and Promotes Leukocyte Recruitment in Intestinal Inflammation
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- GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat
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- The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)
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- The Rap GTPases Regulate B Cell Morphology, Immune-Synapse Formation, and Signaling by Particulate B Cell Receptor Ligands
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- Protein Kinase A (PKA) Isoform RIIβMediates the Synergistic Killing Effect of cAMP and Glucocorticoid in Acute Lymphoblastic Leukemia Cells
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- Rap1 Activation Plays a Regulatory Role in Pancreatic Amylase Secretion
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- Prostaglandin E2-activated Epac Promotes Neointimal Formation of the Rat Ductus Arteriosus by a Process Distinct from That of cAMP-dependent Protein Kinase A
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- Entropy-driven cAMP-dependent Allosteric Control of Inhibitory Interactions in Exchange Proteins Directly Activated by cAMP
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- RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences
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- Identification of CCAAT/Enhancer-binding Proteins as Exchange Protein Activated by cAMP-activated Transcription Factors That Mediate the Induction of the SOCS-3 Gene
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- A Novel Epac-Rap-PP2A Signaling Module Controls cAMP-dependent Akt Regulation
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- Epac and Phospholipase Cϵ Regulate Ca2+Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II
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- The augmenting effect on insulin secretion by oral versus intravenous glucose is exaggerated by high-fat diet in mice
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- ACTH Inhibits bTREK-1 K+Channels through Multiple cAMP-dependent Signaling Pathways
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- Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytes
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- VIP differentially activates 2 integrins, CR1, and matrix metalloproteinase-9 in human monocytes through cAMP/PKA, EPAC, and PI-3K signaling pathways via VIP receptor type 1 and FPRL1
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- Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke
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- Application of an Epac Activator Enhances Neurotransmitter Release at Excitatory Central Synapses
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- Role of the cAMP sensor Epac as a determinant of KATPchannel ATP sensitivity in human pancreatic β-cells and rat INS-1 cells
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- Epac mediates PACAP-dependent long-term depression in the hippocampus
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- Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus
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- Rap1a Is a Key Regulator of Fibroblast Growth Factor 2-Induced Angiogenesis and Together with Rap1b Controls Human Endothelial Cell Functions
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- Pituitary Adenylate Cyclase-Activating Polypeptide 38-Mediated Rin Activation Requires Src and Contributes to the Regulation of Hsp27 Signaling during Neuronal Differentiation
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- Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2
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- Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration
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- Role of Epac1, an Exchange Factor for Rap GTPases, in Endothelial Microtubule Dynamics and Barrier Function
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- Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP Biosensor
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- Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Gαs, a G-protein subunit genetically linked to schizophrenia
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- cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector
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- Chemical sympathectomy further increases muscle protein degradation of acutely diabetic rats
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- Cyclic nucleotide analogs as probes of signaling pathways
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- Targeting bile-acid signalling for metabolic diseases
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- Role of Epac1 in mediating anti-proliferative effects of prostanoid EP2 receptors and cAMP in human lung fibroblasts
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- Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory
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- Widespread Receptivity to Neuropeptide PDF throughout the Neuronal Circadian Clock Network of Drosophila Revealed by Real-Time Cyclic AMP Imaging
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- Defective jejunal and colonic salt absorption and alteredNa+/H+ exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice
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- Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart
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- A Comparison of Donor-Acceptor Pairs for Genetically Encoded FRET Sensors: Application to the Epac cAMP Sensor as an Example
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- The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals
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- Epac signaling is required for hippocampus-dependent memory retrieval
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- The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain
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- Inhibition of human airway smooth muscle cell proliferation by β2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement
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- Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I
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- Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages
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- Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors
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- Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcγ-receptor-mediated phagocytosis in alveolar macrophages
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- Regulation of arginase-1 expression in macrophages by a protein kinase a type I and histone deacetylase dependent pathway
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- Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection
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