EPAC activation inhibits acetaldehyde-induced activation and proliferation of hepatic stellate cell via Rap1

Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression

(2015) Muayad Almahariq et al.   BIOCHEMICAL JOURNAL

Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs

(2015) Yaru Yang et al.   BIOCHIMIE

Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics

(2015) Upasana Banerjee et al.   GENE

Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells

(2015) Qi Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Functions for the cAMP/Epac/Rap1 Signaling Pathway in Low-Dose Endothelial Monocyte-Activating Polypeptide-II-Induced Opening of Blood–Tumor Barrier

(2015) Zhen Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes

(2015) Laëtitia Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The future of EPAC-targeted therapies: agonism versus antagonism

(2015) Euan Parnell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP)

(2014) Owain Llŷr Roberts et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses

(2014) Satoshi Okumura et al.   JOURNAL OF CLINICAL INVESTIGATION

Prostaglandin E2Negatively Regulates the Production of Inflammatory Cytokines/Chemokines and IL-17 in Visceral Leishmaniasis

(2014) Amrita Saha et al.   JOURNAL OF IMMUNOLOGY

Caffeine Inhibits the Activation of Hepatic Stellate Cells Induced by Acetaldehyde via Adenosine A2A Receptor Mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK Signal Pathway

(2014) He Wang et al.   PLoS One

Influence of unrecorded alcohol consumption on liver cirrhosis mortality

(2014) Dirk W Lachenmeier   WORLD JOURNAL OF GASTROENTEROLOGY

Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3

(2013) Miguel Perez-Aso et al.   FASEB JOURNAL

Signaling pathways involved in isoprostane-mediated fibrogenic effects in rat hepatic stellate cells

(2013) Alessandra Acquaviva et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alcoholic liver disease: Pathogenesis, management, and novel targets for therapy

(2013) Eric S Orman et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

RNA Interference against Discoidin Domain Receptor 2 Ameliorates Alcoholic Liver Disease in Rats

(2013) Zheng Luo et al.   PLoS One

Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance

(2013) Miguel Perez-Aso et al.   Purinergic Signalling

Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study

(2012) Elisa C. M. Tonk et al.   ARCHIVES OF TOXICOLOGY

cAMP and Epac in the regulation of tissue fibrosis

(2012) Paul A Insel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immunology in Alcoholic Liver Disease

(2012) Anupama T. Duddempudi   Clinics in Liver Disease

Innate immunity in alcoholic liver disease

(2011) Bin Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Rap1 GTPases: An emerging role in the cardiovasculature

(2011) Selvi C. Jeyaraj et al.   LIFE SCIENCES

Hepatic stellate cells produce vascular endothelial growth factor via phospho-p44/42 mitogen–activated protein kinase/cyclooxygenase-2 pathway

(2011) Yi Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Spleen: A new role for an old player?

(2011) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prostaglandin E2-activated Epac Promotes Neointimal Formation of the Rat Ductus Arteriosus by a Process Distinct from That of cAMP-dependent Protein Kinase A

(2008) Utako Yokoyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

(2008) Holger Rehmann et al.   NATURE

Epac: effectors and biological functions

(2008) Sara S. Roscioni et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

(2008) U. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alcohol induced hepatic fibrosis: Role of acetaldehyde

(2007) Tommaso Mello et al.   MOLECULAR ASPECTS OF MEDICINE