Prostaglandin E2 and Pain—An Update

ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis

(2011) Takahiro Miki et al.   PAIN

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor

(2010) Gabriel Mbalaviele et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain

(2010) John Colucci et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel role of prostaglandin E2 in neuropathic pain

(2010) Shunji Kunori et al.   GLIA

Chronic prostaglandin E2 treatment induces the synthesis of the pain-related peptide substance P and calcitonin gene-related peptide in cultured sensory ganglion explants

(2010) Weiya Ma   JOURNAL OF NEUROCHEMISTRY

Low Nociceptor GRK2 Prolongs Prostaglandin E2 Hyperalgesia via Biased cAMP Signaling to Epac/Rap1, Protein Kinase C , and MEK/ERK

(2010) N. Eijkelkamp et al.   JOURNAL OF NEUROSCIENCE

Extracellular Ca2+ regulates the stimulus-elicited ATP release from urothelium

(2009) Kazumasa Matsumoto-Miyai et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Effects of AF3442 [ N -(9-ethyl-9 H -carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro

(2009) Annalisa Bruno et al.   BIOCHEMICAL PHARMACOLOGY

Role of voltage-gated calcium channels in ascending pain pathways

(2009) Gerald W. Zamponi et al.   BRAIN RESEARCH REVIEWS

The role of PKA and PKCε pathways in prostaglandin E2-mediated hypernociception

(2009) D Sachs et al.   BRITISH JOURNAL OF PHARMACOLOGY

BGC20-1531, a novel, potent and selective prostanoid EP4receptor antagonist: a putative new treatment for migraine headache

(2009) KA Maubach et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prostaglandin E2inhibits the proliferation of human gingival fibroblasts via the EP2receptor and Epac

(2009) Evgeny Weinberg et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prostanoids and inflammation: a new concept arising from receptor knockout mice

(2009) Shuh Narumiya   JOURNAL OF MOLECULAR MEDICINE-JMM

Urothelium EP1 receptor facilitates the micturition reflex in mice

(2008) Xiaojun WANG et al.   BIOMEDICAL RESEARCH-TOKYO

Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain

(2008) Adrian Hall et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microsomal Prostaglandin E Synthase-1 Deletion Suppresses Oxidative Stress and Angiotensin II–Induced Abdominal Aortic Aneurysm Formation

(2008) Miao Wang et al.   CIRCULATION

Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice

(2008) Laura Popp et al.   EUROPEAN JOURNAL OF PAIN

Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease

(2008) M. Wang et al.   JOURNAL OF INTERNAL MEDICINE

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

(2008) D. Xu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

MF498 [N- -2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

(2008) P. Clark et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Injured nerve-derived COX2/PGE2 contributes to the maintenance of neuropathic pain in aged rats

(2008) Weiya Ma et al.   NEUROBIOLOGY OF AGING

Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150

(2008) Xuming Zhang et al.   NEURON

Effect of prostanoid EP4 receptor antagonist, CJ-042,794, in rat models of pain and inflammation

(2007) Akio Murase et al.   EUROPEAN JOURNAL OF PHARMACOLOGY