Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses

Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy

(2013) Lianghui Zhang et al.   CELL

Epac2 Mediates Cardiac β1-Adrenergic–Dependent Sarcoplasmic Reticulum Ca 2+ Leak and Arrhythmia

(2013) Laëtitia Pereira et al.   CIRCULATION

Calcium cycling proteins and heart failure: mechanisms and therapeutics

(2013) Andrew R. Marks   JOURNAL OF CLINICAL INVESTIGATION

Epac activator critically regulates action potential duration by decreasing potassium current in rat adult ventricle

(2013) Fabien Brette et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dysfunctional ryanodine receptors in the heart: New insights into complex cardiovascular diseases

(2013) Steven O. Marx et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mechanism of increased postnatal heart rate and sinoatrial node pacemaker activity in mice

(2013) Takeshi Adachi et al.   Journal of Physiological Sciences

ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca2+ and Mg2+ Regulation

(2013) Jiao Li et al.   PLoS One

Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

(2012) Niels Voigt et al.   CIRCULATION

MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway

(2012) Zhenwei Pan et al.   CIRCULATION

A new calpain inhibitor protects left ventricular dysfunction induced by mild ischemia-reperfusion in in situ rat hearts

(2012) D. Takeshita et al.   Journal of Physiological Sciences

Alterations of atrial Ca2+ handling as cause and consequence of atrial fibrillation

(2011) M. Greiser et al.   CARDIOVASCULAR RESEARCH

Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice

(2011) Na Li et al.   CIRCULATION RESEARCH

Nitric oxide synthase and cyclic GMP signaling in cardiac myocytes: From contractility to remodeling

(2011) Joanna Hammond et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Electrophysiological and Pharmacological Characteristics of Triggered Activity Elicited in Guinea-Pig Pulmonary Vein Myocardium

(2011) Akira Takahara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A Novel Cyclic AMP/Epac1/CaMKI Signaling Cascade Promotes GCM1 Desumoylation and Placental Cell Fusion

(2011) C.-W. Chang et al.   MOLECULAR AND CELLULAR BIOLOGY

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Differential Roles of Epac in Regulating Cell Death in Neuronal and Myocardial Cells

(2010) Sayaka Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β2-Adrenergic Receptor Signaling in the Cardiac Myocyte is Modulated by Interactions With CXCR4

(2010) Thomas J LaRocca et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging

(2010) Katrin Wittköpper et al.   JOURNAL OF CLINICAL INVESTIGATION

Phospholamban Ablation Rescues Sarcoplasmic Reticulum Ca 2+ Handling but Exacerbates Cardiac Dysfunction in CaMKIIδ C Transgenic Mice

(2009) Tong Zhang et al.   CIRCULATION RESEARCH

Activator of G Protein Signaling 8 (AGS8) Is Required for Hypoxia-induced Apoptosis of Cardiomyocytes

(2009) Motohiko Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Protein Kinase Cα by EPAC1 Is Required for the ERK- and CCAAT/Enhancer-binding Protein β-dependent Induction of theSOCS-3Gene by Cyclic AMP in COS1 Cells

(2009) Gillian Borland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice

(2009) Haiyun Ling et al.   JOURNAL OF CLINICAL INVESTIGATION

β-Adrenergic receptor signaling in the heart: Role of CaMKII

(2009) Michael Grimm et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Involvement of the Na+/Ca2+ Exchanger in the Automaticity of Guinea-Pig Pulmonary Vein Myocardium as Revealed by SEA0400

(2009) Iyuki Namekata et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

8-pCPT-2′-O-Me-cAMP-AM: An Improved Epac-Selective cAMP Analogue

(2008) Marjolein J. Vliem et al.   CHEMBIOCHEM

Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy

(2008) Mélanie Métrich et al.   CIRCULATION RESEARCH

Epac and Phospholipase Cϵ Regulate Ca2+Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

(2008) Emily A. Oestreich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic nucleotide analogs as probes of signaling pathways

(2008) Heiko Poppe et al.   NATURE METHODS

Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium

(2008) Iyuki Namekata et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

(2008) U. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA