Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

Differential role of APP and APLPs for neuromuscular synaptic morphology and function

(2014) Maja Klevanski et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Diurnal Patterns of Soluble Amyloid Precursor Protein Metabolites in the Human Central Nervous System

(2014) Justyna A. Dobrowolska et al.   PLoS One

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

(2014) B. G. Wilhelm et al.   SCIENCE

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

(2014) N Milosch et al.   Cell Death & Disease

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

Neto1 associates with the NMDA receptor/amyloid precursor protein complex

(2013) Sarah L. Cousins et al.   JOURNAL OF NEUROCHEMISTRY

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

Hippocampal Network Oscillations in APP/APLP2-Deficient Mice

(2013) Xiaomin Zhang et al.   PLoS One

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

(2012) Carmela Matrone et al.   AGING CELL

Novel G S-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain

(2012) C. Deyts et al.   JOURNAL OF NEUROSCIENCE

Roles of the amyloid precursor protein family in the peripheral nervous system

(2012) John H. Caldwell et al.   MECHANISMS OF DEVELOPMENT

Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function

(2012) Brea Midthune et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

Role of APP for dendritic spine formation and stability

(2011) Christian K. E. Jung et al.   EXPERIMENTAL BRAIN RESEARCH

Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging

(2011) Donat Kögel et al.   EXPERIMENTAL BRAIN RESEARCH

Regulation of alpha-secretase ADAM10 expression and activity

(2011) Kristina Endres et al.   EXPERIMENTAL BRAIN RESEARCH

Functions of the APP gene family in the nervous system: insights from mouse models

(2011) Dorothee Aydin et al.   EXPERIMENTAL BRAIN RESEARCH

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin

(2011) Johannes Prox et al.   EXPERIMENTAL BRAIN RESEARCH

The Upside of APP at Synapses

(2010) Hyang-Sook Hoe et al.   CNS Neuroscience & Therapeutics

sAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

(2010) Ekaterini Copanaki et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

The Effects of Amyloid Precursor Protein on Postsynaptic Composition and Activity

(2009) Hyang-Sook Hoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery

(2009) Sarah L. Cousins et al.   JOURNAL OF NEUROCHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

Amyloid Precursor Protein Regulates Cav1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity

(2009) L. Yang et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β as a positive endogenous regulator of release probability at hippocampal synapses

(2009) Efrat Abramov et al.   NATURE NEUROSCIENCE

Activity requires soluble amyloid precursor protein α to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway

(2008) Nidhi Gakhar-Koppole et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

(2008) Tracy L Young-Pearse et al.   Neural Development

Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice

(2008) Christina Priller et al.   NEUROBIOLOGY OF AGING

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Behavioral Phenotyping Strategies for Mutant Mice

(2008) Jacqueline N. Crawley   NEURON

Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity

(2008) Pascal Steiner et al.   NEURON