Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1

P2Y purinergic receptor-regulated insulin secretion is mediated by a cAMP/Epac/Kv channel pathway

(2015) Yi Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Contribution of Piezo2 to Endothelium-Dependent Pain

(2015) Luiz F. Ferrari et al.   Molecular Pain

Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation

(2015) Wei-Yu Huang et al.   PLoS One

The future of EPAC-targeted therapies: agonism versus antagonism

(2015) Euan Parnell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

(2015) Yingmin Zhu et al.   Scientific Reports

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Nerve Growth Factor Mediates a Switch in Intracellular Signaling for PGE2-Induced Sensitization of Sensory Neurons from Protein Kinase A to Epac

(2014) Michael R. Vasko et al.   PLoS One

Opening paths to novel analgesics: the role of potassium channels in chronic pain

(2014) Christoforos Tsantoulas et al.   TRENDS IN NEUROSCIENCES

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain

(2013) Huijing Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclic AMP sensor EPAC proteins and energy homeostasis

(2013) Muayad Almahariq et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A role for Piezo2 in EPAC1-dependent mechanical allodynia

(2013) N Eijkelkamp et al.   Nature Communications

cAMP-dependent allostery and dynamics in Epac: an NMR view

(2012) Rajeevan Selvaratnam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain

(2012) L.F. Ferrari et al.   NEUROSCIENCE

A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists

(2012) Tamara Tsalkova et al.   PLoS One

cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane

(2012) S. V. Consonni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Putting the pH into phosphatidic acid signaling

(2011) John JH Shin et al.   BMC BIOLOGY

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia

(2011) Huijing Wang et al.   PAIN

Differential Roles of Epac in Regulating Cell Death in Neuronal and Myocardial Cells

(2010) Sayaka Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Nociceptor GRK2 Prolongs Prostaglandin E2 Hyperalgesia via Biased cAMP Signaling to Epac/Rap1, Protein Kinase C , and MEK/ERK

(2010) N. Eijkelkamp et al.   JOURNAL OF NEUROSCIENCE

GRK2: A Novel Cell-Specific Regulator of Severity and Duration of Inflammatory Pain

(2010) N. Eijkelkamp et al.   JOURNAL OF NEUROSCIENCE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Mechanism of Epac Activation

(2009) Tamara Tsalkova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Spatial Control of Epac1 by Cyclic AMP

(2009) B. Ponsioen et al.   MOLECULAR AND CELLULAR BIOLOGY

8-pCPT-2′-O-Me-cAMP-AM: An Improved Epac-Selective cAMP Analogue

(2008) Marjolein J. Vliem et al.   CHEMBIOCHEM

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

(2008) Holger Rehmann et al.   NATURE