Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements

Activation of adenosine A2Areceptor reduces osteoclast formation via PKA- and ERK1/2-mediated suppression of NFκB nuclear translocation

(2013) Aránzazu Mediero et al.   BRITISH JOURNAL OF PHARMACOLOGY

Recent Advances in the Discovery of Small Molecules Targeting Exchange Proteins Directly Activated by cAMP (EPAC)

(2013) Haijun Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of SGLT expression and localization through Epac/PKA-dependent caveolin-1 and F-actin activation in renal proximal tubule cells

(2012) Yu Jin Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of osteoclast structure and function by FAK family kinases

(2012) Brianne J. Ray et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Talin1 and Rap1 Are Critical for Osteoclast Function

(2012) W. Zou et al.   MOLECULAR AND CELLULAR BIOLOGY

Adenosine A2A Receptor Ligation Inhibits Osteoclast Formation

(2011) Aránzazu Mediero et al.   AMERICAN JOURNAL OF PATHOLOGY

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

Rac deletion in osteoclasts causes severe osteopetrosis

(2011) M. Croke et al.   JOURNAL OF CELL SCIENCE

NF- B Signaling Participates in Both RANKL- and IL-4-Induced Macrophage Fusion: Receptor Cross-Talk Leads to Alterations in NF- B Pathways

(2011) M. Yu et al.   JOURNAL OF IMMUNOLOGY

Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells

(2011) Naotoshi Sugimoto et al.   NEUROSCIENCE LETTERS

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Adenylate cyclase and calmodulin-dependent kinase have opposite effects on osteoclastogenesis by regulating the PKA-NFATc1 pathway

(2010) Soo-Hyun Yoon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

(2009) Maria Grandoch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of the classical NF-κB pathway prevents osteoclast bone-resorbing activity

(2009) Niroshani S. Soysa et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo

(2009) Anke J Roelofs et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

(2008) Matteo M. Guerrini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NF-κB functions in osteoclasts

(2008) N.S. Soysa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Actin cytoskeletal organisation in osteoclasts: A model to decipher transmigration and matrix degradation

(2008) F SALTEL et al.   EUROPEAN JOURNAL OF CELL BIOLOGY