Role of Epac2A/Rap1 Signaling in Interplay Between Incretin and Sulfonylurea in Insulin Secretion
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Title
Role of Epac2A/Rap1 Signaling in Interplay Between Incretin and Sulfonylurea in Insulin Secretion
Authors
Keywords
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Journal
DIABETES
Volume 64, Issue 4, Pages 1262-1272
Publisher
American Diabetes Association
Online
2014-10-15
DOI
10.2337/db14-0576
References
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- Mechanism of Intracellular cAMP Sensor Epac2 Activation
- (2011) Sheng Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Susumu Seino et al. JOURNAL OF CLINICAL INVESTIGATION
- Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans
- (2011) Igor Dzhura et al. Islets
- Epac: Defining a New Mechanism for cAMP Action
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- Rim2α Determines Docking and Priming States in Insulin Granule Exocytosis
- (2010) Takao Yasuda et al. Cell Metabolism
- Epac2-dependent mobilization of intracellular Ca2+by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ɛ knockout mice
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- Facilitation of β-cell KATPchannel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac
- (2010) Colin A. Leech et al. Islets
- Roles of cAMP signalling in insulin granule exocytosis
- (2009) S. Seino et al. DIABETES OBESITY & METABOLISM
- Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
- (2009) M. Marre et al. DIABETIC MEDICINE
- Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function
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- The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs
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- Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
- (2008) Holger Rehmann et al. NATURE
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