Newly synthesized cAMP is integrated at a membrane protein complex signalosome to ensure receptor response specificity

Signalling scaffolds and local organization of cellular behaviour

(2015) Lorene K. Langeberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes

(2015) Ping Zhang et al.   STRUCTURE

Differentially Regulated Protein Kinase A (PKA) Activity in Adipose Tissue and Liver Is Associated With Resistance to Diet-Induced Obesity and Glucose Intolerance in Mice That Lack PKA Regulatory Subunit Type IIα

(2014) Edra London et al.   ENDOCRINOLOGY

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Signalosome assembly by domains undergoing dynamic head-to-tail polymerization

(2014) Mariann Bienz   TRENDS IN BIOCHEMICAL SCIENCES

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

Adenylyl Cyclase Anchoring by a Kinase Anchor Protein AKAP5 (AKAP79/150) Is Important for Postsynaptic β-Adrenergic Signaling

(2013) Mingxu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiovascular adenosine receptors: Expression, actions and interactions

(2013) John P. Headrick et al.   PHARMACOLOGY & THERAPEUTICS

Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation

(2013) F Donelson Smith et al.   eLife

Cooperativity in Cellular Biochemical Processes: Noise-Enhanced Sensitivity, Fluctuating Enzyme, Bistability with Nonlinear Feedback, and Other Mechanisms for Sigmoidal Responses

(2012) Hong Qian   Annual Review of Biophysics

Creating Order from Chaos: Cellular Regulation by Kinase Anchoring

(2012) John D. Scott et al.   Annual Review of Pharmacology and Toxicology

Molecular evolution of a-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization

(2012) Keven R Johnson et al.   BMC EVOLUTIONARY BIOLOGY

Anchored phosphatases modulate glucose homeostasis

(2012) Simon A Hinke et al.   EMBO JOURNAL

Cyclic Nucleotide Phosphodiesterase 3 Signaling Complexes

(2012) F. Ahmad et al.   HORMONE AND METABOLIC RESEARCH

Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac

(2012) Delphine Courilleau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP

(2012) Vedangi Sample et al.   Nature Chemical Biology

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New Alternately Colored FRET Sensors for Simultaneous Monitoring of Zn2+ in Multiple Cellular Locations

(2012) Jose G. Miranda et al.   PLoS One

Activation of a Cyclic Amp-Guanine Exchange Factor in Hepatocytes Decreases Nitric Oxide Synthase Expression

(2012) Baochun Zhang et al.   SHOCK

Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex

(2011) M. G. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colocalization of Protein Kinase A with Adenylyl Cyclase Enhances Protein Kinase A Activity during Induction of Long-Lasting Long-Term-Potentiation

(2011) Myungsook Kim et al.   PLoS Computational Biology

AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties

(2010) S. Sehrawat et al.   BLOOD

Ht31, a Protein Kinase A Anchoring Inhibitor, Induces Robust Cholesterol Efflux and Reverses Macrophage Foam Cell Formation through ATP-binding Cassette Transporter A1

(2010) Loretta Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC5 and -6 to α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) Receptors

(2010) Riad Efendiev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins

(2010) Guillaume Pidoux et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

N6-Substituted cAMP Analogs Inhibit bTREK-1 K+ Channels and Stimulate Cortisol Secretion by a Protein Kinase A-Independent Mechanism

(2009) H. Liu et al.   MOLECULAR PHARMACOLOGY

Capturing adenylyl cyclases as potential drug targets

(2009) Sandra Pierre et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphodiesterase 3B Is Localized in Caveolae and Smooth ER in Mouse Hepatocytes and Is Important in the Regulation of Glucose and Lipid Metabolism

(2009) Karin Berger et al.   PLoS One

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation

(2008) Ingrid M. Nijholt et al.   CELLULAR SIGNALLING