Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke

A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke

(2014) Anouk Oldenburger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Immunopathogenesis of chronic obstructive pulmonary disease

(2013) Rebecca A. Holloway et al.   CURRENT OPINION IN PULMONARY MEDICINE

Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice

(2013) Loes E.M. Kistemaker et al.   EUROPEAN RESPIRATORY JOURNAL

Lilium lancifolium Thunb. extract attenuates pulmonary inflammation and air space enlargement in a cigarette smoke-exposed mouse model

(2013) Euijeong Lee et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phospholipase Cɛ links G protein-coupled receptor activation to inflammatory astrocytic responses

(2013) Stephanie S. Dusaban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Bronchitis and Chronic Obstructive Pulmonary Disease

(2012) Victor Kim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CHRNA3/5,IREB2, andADCY2Are Associated with Severe Chronic Obstructive Pulmonary Disease in Poland

(2012) Megan Hardin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

cAMP and Epac in the regulation of tissue fibrosis

(2012) Paul A Insel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of phospholipase Cε in physiological phosphoinositide signaling networks

(2012) Alan V. Smrcka et al.   CELLULAR SIGNALLING

Selective PDE inhibitors as novel treatments for respiratory diseases

(2012) Clive P Page et al.   CURRENT OPINION IN PHARMACOLOGY

Anti-Inflammatory Role of the cAMP Effectors Epac and PKA: Implications in Chronic Obstructive Pulmonary Disease

(2012) Anouk Oldenburger et al.   PLoS One

Phospholipase Cϵ Scaffolds to Muscle-specific A Kinase Anchoring Protein (mAKAPβ) and Integrates Multiple Hypertrophic Stimuli in Cardiac Myocytes

(2011) Lianghui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase Cɛ has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC

(2011) Masahiro Oka et al.   LABORATORY INVESTIGATION

Overexpression of phospholipase Cε in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration

(2010) Nobuyuki Takenaka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

New Pharmacotherapy for Airway Mucus Hypersecretion in Asthma and COPD: Targeting Intracellular Signaling Pathways

(2010) HonYee Lai et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

COPD and the response of the lung to tobacco smoke exposure

(2010) John D. Taylor   PULMONARY PHARMACOLOGY & THERAPEUTICS

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

(2009) Katharine H Banner et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

(2009) Maria Grandoch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Maternal smoking during pregnancy induces airway remodelling in mice offspring

(2009) M. J. Blacquiere et al.   EUROPEAN RESPIRATORY JOURNAL

SIGNAL TRANSDUCTION PATHWAYS LINKING THE ACTIVATION OF ALVEOLAR MACROPHAGES WITH THE RECRUITMENT OF NEUTROPHILS TO LUNGS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

(2009) Vidyasaral Murugan et al.   EXPERIMENTAL LUNG RESEARCH

Crucial Role of Phospholipase C  in Induction of Local Skin Inflammatory Reactions in the Elicitation Stage of Allergic Contact Hypersensitivity

(2009) L. Hu et al.   JOURNAL OF IMMUNOLOGY

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator−/−Mice

(2008) Emanuela M. Bruscia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation

(2008) Ingrid M. Nijholt et al.   CELLULAR SIGNALLING

Frontrunners in novel pharmacotherapy of COPD

(2008) P BARNES   CURRENT OPINION IN PHARMACOLOGY

Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

(2008) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Epac and Phospholipase Cϵ Regulate Ca2+Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

(2008) Emily A. Oestreich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Roles for G Protein-Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies

(2008) Rachna Sadana et al.   NEUROSIGNALS

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

(2008) U. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA